Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Pkp4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PKP4 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | Pkp4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKP4 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PKP4 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pkp4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKP4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PKP4 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PKP4 mRNA | CTD | PMID:20106945 and PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PKP4 mRNA | CTD | PMID:21215274 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PKP4 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | PKP4 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of PKP4 mRNA | CTD | PMID:21179406 | 2-palmitoylglycerol | increases expression | ISO | PKP4 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of PKP4 mRNA | CTD | PMID:37199045 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Pkp4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PKP4 mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PKP4 mRNA | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Pkp4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of PKP4 promoter | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Pkp4 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of PKP4 promoter | CTD | PMID:33297965 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PKP4 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PKP4 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PKP4 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | aflatoxin B1 | affects expression | ISO | PKP4 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PKP4 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases methylation | ISO | PKP4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PKP4 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PKP4 mRNA | CTD | PMID:15498508 and PMID:33167477 | alpha-pinene | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PKP4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of PKP4 mRNA | CTD | PMID:32699268 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of PKP4 mRNA | CTD | PMID:30047161 | aristolochic acid A | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PKP4 mRNA | CTD | PMID:33212167 | atrazine | increases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Atrazine results in increased expression of PKP4 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PKP4 mRNA | CTD | PMID:20106945 and PMID:21632981 | benzo[a]pyrene | decreases methylation | ISO | PKP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PKP4 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20382639 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PKP4 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [[ginger extract results in increased abundance of Oils and Volatile] which co-treated with bisphenol A] affects the expression of PKP4 protein | CTD | PMID:33376534 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PKP4 mRNA | CTD | PMID:30816183 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of PKP4 protein | CTD | PMID:28903499 | butanal | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PKP4 mRNA | CTD | PMID:26079696 | cadmium atom | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Cadmium results in decreased expression of PKP4 mRNA | CTD | PMID:23369406 | cadmium atom | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PKP4 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PKP4 mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | PKP4 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PKP4 protein | CTD | PMID:35688186 | calcitriol | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of PKP4 mRNA | CTD | PMID:21592394 | calcitriol | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of PKP4 mRNA | CTD | PMID:21592394 | CGP 52608 | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PKP4 gene] | CTD | PMID:28238834 | cobalt dichloride | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PKP4 mRNA | CTD | PMID:19320972 | copper(II) sulfate | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of PKP4 mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | PKP4 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of PKP4 protein | CTD | PMID:35688186 | crocidolite asbestos | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PKP4 mRNA | CTD | PMID:29279043 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of PKP4 mRNA | CTD | PMID:27523638 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PKP4 mRNA | CTD | PMID:21865292 | cyclosporin A | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PKP4 mRNA | CTD | PMID:25562108 | DDT | increases methylation | EXP | | 6480464 | DDT results in increased methylation of PKP4 gene | CTD | PMID:30207508 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of PKP4 mRNA | CTD | PMID:21266533 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PKP4 mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PKP4 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PKP4 mRNA | CTD | PMID:29391264 | entinostat | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | entinostat results in decreased expression of PKP4 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKP4 mRNA | CTD | PMID:27188386 | ethanol | increases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Ethanol results in increased expression of PKP4 mRNA | CTD | PMID:30319688 | fenthion | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Fenthion results in decreased expression of PKP4 mRNA | CTD | PMID:34813904 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PKP4 mRNA | CTD | PMID:24136188 and PMID:24793618 | folic acid | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PKP4 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | Pkp4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PKP4 mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PKP4 mRNA | CTD | PMID:23649840 | FR900359 | affects phosphorylation | ISO | PKP4 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PKP4 protein | CTD | PMID:37730182 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of PKP4 mRNA | CTD | PMID:24136188 | indometacin | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of PKP4 mRNA | CTD | PMID:16984733 | levonorgestrel | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PKP4 mRNA | CTD | PMID:19074003 | methidathion | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | methidathion results in decreased expression of PKP4 mRNA | CTD | PMID:34813904 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of PKP4 gene | CTD | PMID:35440735 | methylmercury chloride | increases expression | ISO | PKP4 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PKP4 mRNA | CTD | PMID:23179753 and PMID:26272509 | methylmercury chloride | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP4 mRNA | CTD | PMID:27188386 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PKP4 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PKP4 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | p-toluidine | increases expression | EXP | | 6480464 | 4-toluidine results in increased expression of PKP4 mRNA | CTD | PMID:27638505 | paracetamol | affects expression | ISO | Pkp4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PKP4 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PKP4 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PKP4 mRNA | CTD | PMID:21420995 | phenobarbital | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of PKP4 mRNA | CTD | PMID:23091169 | phenylephrine | decreases expression | EXP | | 6480464 | Phenylephrine results in decreased expression of PKP4 mRNA | CTD | PMID:18158353 | quercetin | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of PKP4 mRNA | CTD | PMID:21632981 | quercetin | decreases phosphorylation | ISO | PKP4 (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of PKP4 protein | CTD | PMID:35688186 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of PKP4 mRNA | CTD | PMID:28374803 | SB 431542 | increases expression | ISO | PKP4 (Homo sapiens) | 6480464 | 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of PKP4 protein | CTD | PMID:25670856 | SB 431542 | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sirolimus | increases expression | EXP | | 6480464 | Sirolimus results in increased expression of PKP4 mRNA | CTD | PMID:21865292 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of PKP4 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PKP4 mRNA | CTD | PMID:31533062 | tacrolimus hydrate | decreases expression | EXP | | 6480464 | Tacrolimus results in decreased expression of PKP4 mRNA | CTD | PMID:21865292 | tamibarotene | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | tamibarotene results in decreased expression of PKP4 mRNA | CTD | PMID:15498508 | tert-butyl hydroperoxide | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of PKP4 mRNA | CTD | PMID:15336504 | testosterone | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of PKP4 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of PKP4 mRNA | CTD | PMID:33848595 | testosterone | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of PKP4 mRNA | CTD | PMID:21592394 | testosterone undecanoate | multiple interactions | ISO | PKP4 (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PKP4 mRNA | CTD | PMID:19074003 | tetrachloromethane | affects expression | ISO | Pkp4 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PKP4 mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of PKP4 mRNA | CTD | PMID:31919559 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PKP4 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PKP4 mRNA | CTD | PMID:25729387 | triptonide | increases expression | ISO | Pkp4 (Mus musculus) | 6480464 | triptonide results in increased expression of PKP4 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | Pkp4 (Mus musculus) | 6480464 | troglitazone results in decreased expression of PKP4 mRNA | CTD | PMID:28973697 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of PKP4 gene | CTD | PMID:30207508 | zoledronic acid | decreases expression | ISO | PKP4 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of PKP4 mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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