Cela3b (chymotrypsin like elastase 3B) - Rat Genome Database

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Gene: Cela3b (chymotrypsin like elastase 3B) Rattus norvegicus
Analyze
Symbol: Cela3b
Name: chymotrypsin like elastase 3B
RGD ID: 1307819
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to several human genes including CELA3B (chymotrypsin like elastase 3B); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Di-n-hexyl phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chymotrypsin-like elastase family member 3B; chymotrypsin-like elastase family, member 3B; Ela3b; elastase 3B, pancreatic; LOC298567
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,912,170 - 154,920,333 (-)NCBIGRCr8
mRatBN7.25149,628,773 - 149,636,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,628,773 - 149,636,937 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,325,488 - 152,333,569 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,099,789 - 154,107,866 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,081,784 - 154,089,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,763,877 - 155,772,048 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,763,877 - 155,772,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,520,758 - 159,528,921 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,178,728 - 156,186,891 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,189,653 - 156,213,892 (-)NCBI
Celera5148,025,627 - 148,033,790 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cela3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,912,170 - 154,920,333 (-)NCBIGRCr8
mRatBN7.25149,628,773 - 149,636,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,628,773 - 149,636,937 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,325,488 - 152,333,569 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,099,789 - 154,107,866 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,081,784 - 154,089,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,763,877 - 155,772,048 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,763,877 - 155,772,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,520,758 - 159,528,921 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,178,728 - 156,186,891 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,189,653 - 156,213,892 (-)NCBI
Celera5148,025,627 - 148,033,790 (-)NCBICelera
Cytogenetic Map5q36NCBI
CELA3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,977,022 - 21,998,642 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,977,022 - 21,998,642 (+)EnsemblGRCh38hg38GRCh38
GRCh37122,303,515 - 22,315,847 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,176,005 - 22,188,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 34122,048,723 - 22,061,151NCBI
Celera120,626,233 - 20,638,664 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,547,329 - 20,559,574 (+)NCBIHuRef
CHM1_1122,415,939 - 22,428,380 (+)NCBICHM1_1
T2T-CHM13v2.0121,800,816 - 21,822,459 (+)NCBIT2T-CHM13v2.0
Cela3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,148,319 - 137,157,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,148,310 - 137,157,851 (-)EnsemblGRCm39 Ensembl
GRCm384137,421,008 - 137,430,520 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,420,999 - 137,430,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,976,923 - 136,986,435 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,693,084 - 136,702,596 (-)NCBIMGSCv36mm8
Celera4138,963,490 - 138,964,534 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.9NCBI
Cela3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554522,190,177 - 2,194,453 (+)NCBIChiLan1.0ChiLan1.0
LOC478196
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,223,095 - 77,228,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,726,093 - 73,731,735 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0277,780,576 - 77,786,209 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,780,574 - 77,786,318 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,600,697 - 74,606,308 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,609,929 - 75,615,552 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,613,826 - 76,619,459 (-)NCBIUU_Cfam_GSD_1.0
LOC110261434
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1679,995,337 - 80,002,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CELA3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,646,881 - 110,654,841 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,647,286 - 110,654,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,641,531 - 5,649,416 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cela3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,773,548 - 6,781,998 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cela3b
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000036788
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 5 8 5 2
Low 2 11 2 10 2 4 5 20 2 35 7 4
Below cutoff 26 14 7 1 7 3 5 19 17 4 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036788   ⟹   ENSRNOP00000036674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,628,773 - 149,636,937 (-)Ensembl
Rnor_6.0 Ensembl5155,763,877 - 155,772,040 (-)Ensembl
RefSeq Acc Id: NM_001106692   ⟹   NP_001100162
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,912,170 - 154,920,333 (-)NCBI
mRatBN7.25149,628,773 - 149,636,937 (-)NCBI
Rnor_6.05155,763,877 - 155,772,040 (-)NCBI
Rnor_5.05159,520,758 - 159,528,921 (-)NCBI
RGSC_v3.45156,178,728 - 156,186,891 (-)RGD
Celera5148,025,627 - 148,033,790 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100162 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80837 (Get FASTA)   NCBI Sequence Viewer  
  EDL80838 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036674
  ENSRNOP00000036674.5
Reference Protein Sequences
RefSeq Acc Id: NP_001100162   ⟸   NM_001106692
- Peptide Label: precursor
- UniProtKB: D3ZFG3 (UniProtKB/TrEMBL),   A6ITD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036674   ⟸   ENSRNOT00000036788
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFG3-F1-model_v2 AlphaFold D3ZFG3 1-269 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694178
Promoter ID:EPDNEW_R4703
Type:multiple initiation site
Name:Cela3b_1
Description:chymotrypsin-like elastase family, member 3B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05155,772,023 - 155,772,083EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307819 AgrOrtholog
BioCyc Gene G2FUF-39478 BioCyc
Ensembl Genes ENSRNOG00000021619 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036788 ENTREZGENE
  ENSRNOT00000036788.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:298567 UniProtKB/TrEMBL
NCBI Gene 298567 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER UniProtKB/TrEMBL
  CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 3B UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Cela3b PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021619 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6ITD6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFG3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Cela3b  chymotrypsin like elastase 3B  Cela3b  chymotrypsin-like elastase family, member 3B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Cela3b  chymotrypsin-like elastase family, member 3B  Ela3b  elastase 3B, pancreatic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ela3b  elastase 3B, pancreatic  Ela3b_predicted  elastase 3B, pancreatic (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Ela3b_predicted  elastase 3B, pancreatic (predicted)      Symbol and Name status set to approved 70820 APPROVED