Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of MLEC mRNA | CTD | PMID:30723492 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of MLEC mRNA | CTD | PMID:29581250 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Mlec (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MLEC mRNA | CTD | PMID:33387578 | 2-hydroxypropanoic acid | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of MLEC mRNA | CTD | PMID:30851411 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Mlec (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of MLEC mRNA | CTD | PMID:26251327 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of MLEC mRNA | CTD | PMID:28522335 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | MLEC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MLEC mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Mlec (Mus musculus) | 6480464 | Fenretinide results in decreased expression of MLEC mRNA | CTD | PMID:28973697 | aflatoxin B1 | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of MLEC mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | MLEC (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of MLEC gene | CTD | PMID:27153756 | allethrin | multiple interactions | EXP | | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of MLEC protein | CTD | PMID:34896426 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of MLEC mRNA | CTD | PMID:30779732 | arsane | affects methylation | ISO | MLEC (Homo sapiens) | 6480464 | Arsenic affects the methylation of MLEC gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | MLEC (Homo sapiens) | 6480464 | Arsenic affects the methylation of MLEC gene | CTD | PMID:25304211 | benzo[a]pyrene | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of MLEC mRNA | CTD | PMID:19770486 and PMID:21715664 | bisphenol A | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | bisphenol A results in increased expression of MLEC mRNA and bisphenol A results in increased expression of MLEC protein | CTD | PMID:29275510 and PMID:37567409 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of MLEC mRNA | CTD | PMID:30816183 more ... | bisphenol F | multiple interactions | ISO | MLEC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MLEC mRNA | CTD | PMID:28628672 | captan | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Captan results in increased expression of MLEC mRNA | CTD | PMID:31558096 | carbon nanotube | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of MLEC mRNA | CTD | PMID:18668222 | choline | multiple interactions | ISO | Mlec (Mus musculus) | 6480464 | [Dietary Fats co-treated with Choline deficiency] results in increased expression of MLEC mRNA and PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of MLEC mRNA] | CTD | PMID:29246445 | cisplatin | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Cisplatin results in increased expression of MLEC mRNA | CTD | PMID:27392435 | clobetasol | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Clobetasol results in increased expression of MLEC mRNA | CTD | PMID:27462272 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MLEC mRNA | CTD | PMID:17602206 | copper(II) sulfate | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of MLEC mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of MLEC mRNA | CTD | PMID:25562108 | cyhalothrin | multiple interactions | EXP | | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of MLEC protein | CTD | PMID:34896426 | cypermethrin | multiple interactions | EXP | | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of MLEC protein | CTD | PMID:34896426 | cyproconazole | increases expression | ISO | Mlec (Mus musculus) | 6480464 | cyproconazole results in increased expression of MLEC mRNA | CTD | PMID:22334560 | dexamethasone | multiple interactions | ISO | MLEC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MLEC mRNA | CTD | PMID:28628672 | diazinon | increases methylation | ISO | MLEC (Homo sapiens) | 6480464 | Diazinon results in increased methylation of MLEC gene | CTD | PMID:22964155 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of MLEC mRNA | CTD | PMID:21266533 | diuron | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Diuron results in decreased expression of MLEC mRNA | CTD | PMID:35967413 | elemental selenium | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Selenium results in increased expression of MLEC mRNA | CTD | PMID:19244175 | elemental selenium | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Selenium results in decreased expression of MLEC mRNA | CTD | PMID:19244175 | elemental selenium | multiple interactions | ISO | MLEC (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of MLEC mRNA | CTD | PMID:19244175 | epoxiconazole | increases expression | ISO | Mlec (Mus musculus) | 6480464 | epoxiconazole results in increased expression of MLEC mRNA | CTD | PMID:22334560 | ethanol | affects expression | ISO | Mlec (Mus musculus) | 6480464 | Ethanol affects the expression of MLEC mRNA | CTD | PMID:30319688 | ethanol | affects splicing | ISO | Mlec (Mus musculus) | 6480464 | Ethanol affects the splicing of MLEC mRNA | CTD | PMID:30319688 | fenvalerate | multiple interactions | EXP | | 6480464 | [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of MLEC protein | CTD | PMID:34896426 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of MLEC mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of MLEC mRNA | CTD | PMID:24136188 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of MLEC mRNA | CTD | PMID:24793618 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of MLEC mRNA | CTD | PMID:25539665 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of MLEC mRNA | CTD | PMID:22061828 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of MLEC mRNA | CTD | PMID:33387578 | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of MLEC mRNA | CTD | PMID:24136188 | glyphosate | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Glyphosate results in increased expression of MLEC protein | CTD | PMID:37208198 | indometacin | multiple interactions | ISO | MLEC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MLEC mRNA | CTD | PMID:28628672 | inulin | multiple interactions | ISO | Mlec (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of MLEC mRNA | CTD | PMID:36331819 | ivermectin | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of MLEC protein | CTD | PMID:32959892 | lead diacetate | increases expression | ISO | Mlec (Mus musculus) | 6480464 | lead acetate results in increased expression of MLEC mRNA | CTD | PMID:21829687 | leflunomide | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | leflunomide results in decreased expression of MLEC mRNA | CTD | PMID:28988120 | methyl methanesulfonate | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of MLEC mRNA | CTD | PMID:23649840 | miconazole | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Miconazole results in increased expression of MLEC mRNA | CTD | PMID:27462272 | mitomycin C | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Mitomycin results in increased expression of MLEC mRNA | CTD | PMID:25270620 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MLEC mRNA | CTD | PMID:17602206 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of MLEC mRNA | CTD | PMID:24136188 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of MLEC mRNA | CTD | PMID:24136188 | paclitaxel | affects response to substance | ISO | MLEC (Homo sapiens) | 6480464 | MLEC protein affects the susceptibility to Paclitaxel | CTD | PMID:16217747 | paracetamol | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of MLEC mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of MLEC mRNA | CTD | PMID:21420995 | paracetamol | affects expression | ISO | Mlec (Mus musculus) | 6480464 | Acetaminophen affects the expression of MLEC mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Mlec (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of MLEC mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of MLEC mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Mlec (Mus musculus) | 6480464 | Phenobarbital affects the expression of MLEC mRNA | CTD | PMID:19136022 and PMID:23091169 | piperonyl butoxide | increases expression | EXP | | 6480464 | Piperonyl Butoxide results in increased expression of MLEC mRNA | CTD | PMID:22484513 | pirinixic acid | affects expression | ISO | Mlec (Mus musculus) | 6480464 | pirinixic acid affects the expression of MLEC mRNA | CTD | PMID:19136022 | pirinixic acid | increases expression | ISO | Mlec (Mus musculus) | 6480464 | pirinixic acid results in increased expression of MLEC mRNA | CTD | PMID:23811191 | propiconazole | increases expression | ISO | Mlec (Mus musculus) | 6480464 | propiconazole results in increased expression of MLEC mRNA | CTD | PMID:21278054 and PMID:22334560 | pyrethrins | decreases expression | EXP | | 6480464 | Pyrethrins results in decreased expression of MLEC protein | CTD | PMID:34896426 | rac-lactic acid | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of MLEC mRNA | CTD | PMID:30851411 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of MLEC mRNA | CTD | PMID:28374803 | SB 431542 | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of MLEC protein | CTD | PMID:25670856 | selenium atom | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Selenium results in decreased expression of MLEC mRNA | CTD | PMID:19244175 | selenium atom | multiple interactions | ISO | MLEC (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of MLEC mRNA | CTD | PMID:19244175 | selenium atom | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Selenium results in increased expression of MLEC mRNA | CTD | PMID:19244175 | sodium fluoride | decreases expression | ISO | Mlec (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of MLEC protein | CTD | PMID:28918527 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of MLEC mRNA | CTD | PMID:19281266 | testosterone | decreases expression | ISO | Mlec (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of MLEC mRNA | CTD | PMID:33848595 | testosterone enanthate | affects expression | ISO | MLEC (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of MLEC mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of MLEC mRNA | CTD | PMID:30723492 | tetrachloromethane | increases expression | ISO | Mlec (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of MLEC mRNA | CTD | PMID:31919559 | thapsigargin | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of MLEC mRNA | CTD | PMID:22378314 | thapsigargin | decreases expression | ISO | Mlec (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of MLEC protein | CTD | PMID:24648495 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of MLEC mRNA | CTD | PMID:23411599 | titanium dioxide | increases expression | ISO | Mlec (Mus musculus) | 6480464 | titanium dioxide results in increased expression of MLEC mRNA | CTD | PMID:23557971 | trimellitic anhydride | increases expression | ISO | Mlec (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of MLEC mRNA | CTD | PMID:19042947 | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of MLEC mRNA | CTD | PMID:30589522 | tunicamycin | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of MLEC mRNA | CTD | PMID:22378314 and PMID:29453283 | valproic acid | affects expression | ISO | Mlec (Mus musculus) | 6480464 | Valproic Acid affects the expression of MLEC mRNA | CTD | PMID:17292431 | valproic acid | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of MLEC mRNA | CTD | PMID:23179753 and PMID:27188386 | valproic acid | affects expression | ISO | MLEC (Homo sapiens) | 6480464 | Valproic Acid affects the expression of MLEC mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of MLEC mRNA | CTD | PMID:23034163 | vitamin E | multiple interactions | ISO | MLEC (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of MLEC mRNA | CTD | PMID:19244175 | vitamin E | decreases expression | ISO | MLEC (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of MLEC mRNA | CTD | PMID:19244175 | zinc atom | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of MLEC mRNA | CTD | PMID:22171008 | zinc(0) | increases expression | ISO | MLEC (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of MLEC mRNA | CTD | PMID:22171008 | |