Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RAPGEF6 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RAPGEF6 mRNA | CTD | PMID:22079256 | 1,2-dichloroethane | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of RAPGEF6 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RAPGEF6 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of RAPGEF6 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RAPGEF6 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RAPGEF6 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RAPGEF6 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RAPGEF6 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RAPGEF6 mRNA | CTD | PMID:21570461 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of RAPGEF6 mRNA | CTD | PMID:20188158 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of RAPGEF6 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | RAPGEF6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of RAPGEF6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of RAPGEF6 mRNA | CTD | PMID:32699268 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of RAPGEF6 mRNA | CTD | PMID:28959563 | acrylamide | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of RAPGEF6 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of RAPGEF6 mRNA | CTD | PMID:19770486 | aflatoxin M1 | increases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Aflatoxin M1 results in increased expression of RAPGEF6 mRNA | CTD | PMID:30928695 | alpha-pinene | multiple interactions | ISO | RAPGEF6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of RAPGEF6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of RAPGEF6 mRNA | CTD | PMID:32699268 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of RAPGEF6 mRNA | CTD | PMID:30047161 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of RAPGEF6 mRNA | CTD | PMID:30779732 | antirheumatic drug | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of RAPGEF6 mRNA | CTD | PMID:24449571 | arsane | affects methylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RAPGEF6 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RAPGEF6 gene | CTD | PMID:25304211 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[e]pyrene | decreases methylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of RAPGEF6 intron | CTD | PMID:30157460 | bisphenol A | increases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of RAPGEF6 mRNA | CTD | PMID:26063408 and PMID:35598803 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RAPGEF6 mRNA | CTD | PMID:34947998 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of RAPGEF6 gene | CTD | PMID:28505145 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RAPGEF6 mRNA | CTD | PMID:25181051 and PMID:32145629 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of RAPGEF6 mRNA | CTD | PMID:19010381 | caffeine | affects phosphorylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of RAPGEF6 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of RAPGEF6 mRNA | CTD | PMID:25554681 | carbon nanotube | affects expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Nanotubes and Carbon affects the expression of RAPGEF6 mRNA | CTD | PMID:31978390 | chlorpyrifos | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of RAPGEF6 mRNA | CTD | PMID:37019170 | cobalt dichloride | affects expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | cobaltous chloride affects the expression of RAPGEF6 mRNA alternative form | CTD | PMID:19320972 | cocaine | multiple interactions | ISO | Rapgef6 (Mus musculus) | 6480464 | HDAC5 affects the reaction [Cocaine affects the expression of RAPGEF6 mRNA] | CTD | PMID:17988634 | copper(II) sulfate | increases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of RAPGEF6 mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of RAPGEF6 protein | CTD | PMID:35688186 | crocidolite asbestos | affects expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Asbestos and Crocidolite affects the expression of RAPGEF6 mRNA | CTD | PMID:17331233 | CU-O LINKAGE | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | cupric oxide results in decreased expression of RAPGEF6 mRNA | CTD | PMID:22077320 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of RAPGEF6 mRNA | CTD | PMID:27523638 | cyclosporin A | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of RAPGEF6 mRNA | CTD | PMID:25562108 | dexamethasone | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of RAPGEF6 mRNA | CTD | PMID:22733784 | Diisodecyl phthalate | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | diisodecyl phthalate results in decreased expression of RAPGEF6 mRNA | CTD | PMID:25270620 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of RAPGEF6 mRNA | CTD | PMID:21551480 | doxorubicin | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of RAPGEF6 mRNA | CTD | PMID:29803840 | elemental selenium | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Selenium results in decreased expression of RAPGEF6 mRNA | CTD | PMID:19244175 | folic acid | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of RAPGEF6 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of RAPGEF6 mRNA | CTD | PMID:20655997 and PMID:23649840 | FR900359 | affects phosphorylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of RAPGEF6 protein | CTD | PMID:37730182 | indometacin | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Indomethacin results in decreased expression of RAPGEF6 mRNA | CTD | PMID:16984733 | lead(0) | affects expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Lead affects the expression of RAPGEF6 mRNA | CTD | PMID:28903495 | levonorgestrel | multiple interactions | ISO | RAPGEF6 (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of RAPGEF6 mRNA | CTD | PMID:19074003 | methapyrilene | decreases methylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of RAPGEF6 intron | CTD | PMID:30157460 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of RAPGEF6 mRNA | CTD | PMID:30047161 | monosodium L-glutamate | multiple interactions | ISO | Rapgef6 (Mus musculus) | 6480464 | [Trans Fatty Acids co-treated with Sodium Glutamate] results in increased expression of RAPGEF6 mRNA | CTD | PMID:22078008 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Rapgef6 (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of RAPGEF6 intron | CTD | PMID:27776689 | ochratoxin A | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | ochratoxin A results in decreased expression of RAPGEF6 mRNA | CTD | PMID:30763683 | ozone | multiple interactions | ISO | RAPGEF6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of RAPGEF6 mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | ISO | Rapgef6 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of RAPGEF6 mRNA | CTD | PMID:34911549 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RAPGEF6 mRNA | CTD | PMID:33387578 | potassium chromate | multiple interactions | ISO | RAPGEF6 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RAPGEF6 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of RAPGEF6 mRNA | CTD | PMID:22079256 | potassium dichromate | increases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of RAPGEF6 mRNA | CTD | PMID:23608068 | quercetin | decreases phosphorylation | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of RAPGEF6 protein | CTD | PMID:35688186 | selenium atom | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Selenium results in decreased expression of RAPGEF6 mRNA | CTD | PMID:19244175 | sunitinib | increases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of RAPGEF6 mRNA | CTD | PMID:31533062 | testosterone undecanoate | multiple interactions | ISO | RAPGEF6 (Homo sapiens) | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of RAPGEF6 mRNA | CTD | PMID:19074003 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RAPGEF6 mRNA | CTD | PMID:34492290 | trichostatin A | increases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of RAPGEF6 mRNA | CTD | PMID:24935251 | triptonide | increases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | triptonide results in increased expression of RAPGEF6 mRNA | CTD | PMID:33045310 | tungsten | decreases expression | ISO | Rapgef6 (Mus musculus) | 6480464 | Tungsten results in decreased expression of RAPGEF6 mRNA | CTD | PMID:30912803 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of RAPGEF6 mRNA | CTD | PMID:19015723 | vitamin E | decreases expression | ISO | RAPGEF6 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of RAPGEF6 mRNA | CTD | PMID:19244175 | | 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