Gins4 (GINS complex subunit 4) - Rat Genome Database

Name: Gins4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Gins4 (GINS complex subunit 4) Rattus norvegicus

Analyze

Symbol:

Gins4

Name:

GINS complex subunit 4

RGD ID:

1307397

Description:

Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via break-induced replication. Predicted to act upstream of or within inner cell mass cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CMG complex and GINS complex. Orthologous to human GINS4 (GINS complex subunit 4); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2810037c03rik; DNA replication complex GINS protein SLD5; GINS complex subunit 4 (Sld5 homolog); LOC290842; MGC124661; RGD1307397; similar to RIKEN cDNA 2810037C03; SLD5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GINS4 (GINS complex subunit 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gins4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gins4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GINS4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GINS4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gins4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GINS4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GINS4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gins4 (GINS complex subunit 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NSD2 (nuclear receptor binding SET domain protein 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Gins4 (GINS complex subunit 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GINS4 (GINS complex subunit 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gins4 (GINS complex subunit 4 (Sld5 homolog))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SLD5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sld5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sld-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gins4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	75,489,990 - 75,502,455 (+)	NCBI		GRCr8
mRatBN7.2	16	68,787,572 - 68,799,938 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	68,767,339 - 68,802,273 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	74,065,862 - 74,077,615 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	77,494,180 - 77,505,632 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	72,743,364 - 72,754,816 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	73,584,412 - 73,596,808 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	73,584,521 - 73,596,793 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	73,218,686 - 73,230,611 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	73,245,883 - 73,257,267 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	73,246,086 - 73,257,532 (+)	NCBI
Celera	16	66,679,100 - 66,691,881 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

cadmium dichloride (EXP,ISO)

cefaloridine (EXP)

chlordecone (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

Enterolactone (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

indole-3-methanol (EXP)

methidathion (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

niclosamide (ISO)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

quercetin (ISO)

quinolin-8-ol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA unwinding involved in DNA replication (IEA,ISO)

DNA-templated DNA replication (IEA)

double-strand break repair via break-induced replication (IBA,IEA)

inner cell mass cell proliferation (IEA,ISO)

Cellular Component

chromosome (IEA)

CMG complex (IEA,ISO,ISS)

cytoplasm (IEA,ISO)

GINS complex (IBA,IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16338220	PMID:24244394

Genomics

Comparative Map Data

Gins4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	75,489,990 - 75,502,455 (+)	NCBI		GRCr8
mRatBN7.2	16	68,787,572 - 68,799,938 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	68,767,339 - 68,802,273 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	74,065,862 - 74,077,615 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	77,494,180 - 77,505,632 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	72,743,364 - 72,754,816 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	73,584,412 - 73,596,808 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	73,584,521 - 73,596,793 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	73,218,686 - 73,230,611 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	73,245,883 - 73,257,267 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	73,246,086 - 73,257,532 (+)	NCBI
Celera	16	66,679,100 - 66,691,881 (+)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

GINS4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	41,529,261 - 41,545,030 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	41,529,218 - 41,545,030 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	41,386,780 - 41,402,549 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	41,505,903 - 41,519,068 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	40,335,805 - 40,351,649 (+)	NCBI		Celera
Cytogenetic Map	8	p11.21	NCBI
HuRef	8	39,914,514 - 39,930,224 (+)	NCBI		HuRef
CHM1_1	8	41,435,115 - 41,450,955 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	41,802,893 - 41,818,725 (+)	NCBI		T2T-CHM13v2.0

Gins4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	23,716,626 - 23,727,684 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	23,716,632 - 23,727,675 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	23,226,610 - 23,237,668 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	23,226,616 - 23,237,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	24,337,082 - 24,348,140 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	24,692,170 - 24,703,204 (-)	NCBI		MGSCv36	mm8
Celera	8	24,723,351 - 24,734,350 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	11.42	NCBI

Gins4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955536	1,360,811 - 1,375,712 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955536	1,360,811 - 1,375,691 (-)	NCBI	ChiLan1.0	ChiLan1.0

GINS4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	59,981,167 - 59,998,503 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	35,698,447 - 35,724,384 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	40,774,253 - 40,790,609 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	38,224,907 - 38,240,562 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	38,224,907 - 38,240,562 (+)	Ensembl	panpan1.1		panPan2

GINS4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	24,055,720 - 24,068,469 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	24,056,963 - 24,069,052 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	24,560,464 - 24,573,213 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	25,803,727 - 25,816,480 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	25,804,796 - 25,816,475 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	24,175,525 - 24,188,278 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	24,737,638 - 24,750,387 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	24,788,978 - 24,801,727 (-)	NCBI		UU_Cfam_GSD_1.0

Gins4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	47,086,936 - 47,103,245 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936785	1,043,143 - 1,059,636 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936785	1,043,342 - 1,059,635 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GINS4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	10,656,884 - 10,668,664 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	10,656,869 - 10,668,664 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	12,084,312 - 12,096,482 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GINS4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	39,509,833 - 39,523,099 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	39,509,847 - 39,526,321 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	2,294,263 - 2,310,377 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gins4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	1,735,220 - 1,749,220 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624780	1,735,454 - 1,749,219 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gins4
75 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	45
Count of miRNA genes:	43
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000024301
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	19004435	75226532	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	24325513	69325513	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	25152793	70152793	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	35288870	80288870	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	37752156	82752156	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	37752156	82752156	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	42396345	84729064	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	52726464	84729064	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	52726464	84729064	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	52726464	84729064	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	55711087	83402471	Rat
1298527	Arunc2	Aerobic running capacity QTL 2	2.9		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	68532716	75029966	Rat

Markers in Region

RH139000

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	68,793,422 - 68,793,549 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	73,590,291 - 73,590,417	NCBI	Rnor6.0
Rnor_5.0	16	73,224,549 - 73,224,675	UniSTS	Rnor5.0
RGSC_v3.4	16	73,251,653 - 73,251,779	UniSTS	RGSC3.4
Celera	16	66,684,870 - 66,684,996	UniSTS
RH 3.4 Map	16	660.8	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

RH141335

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	68,799,658 - 68,799,840 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	73,596,529 - 73,596,710	NCBI	Rnor6.0
Rnor_5.0	16	73,230,332 - 73,230,513	UniSTS	Rnor5.0
RGSC_v3.4	16	73,257,003 - 73,257,184	UniSTS	RGSC3.4
Celera	16	66,691,617 - 66,691,798	UniSTS
RH 3.4 Map	16	662.1	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	25	18	18	18			57	20	39	3
Low		17	32	23	1	23	8	11	17	15	2	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001030027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000024301 ⟹ ENSRNOP00000024301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	68,767,339 - 68,799,921 (+)	Ensembl
Rnor_6.0 Ensembl	16	73,584,521 - 73,596,793 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111646 ⟹ ENSRNOP00000089454

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	68,767,339 - 68,799,921 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114555 ⟹ ENSRNOP00000084853

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	68,767,339 - 68,802,273 (+)	Ensembl

RefSeq Acc Id:

NM_001030027 ⟹ NP_001025198

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	75,490,187 - 75,502,455 (+)	NCBI
mRatBN7.2	16	68,787,653 - 68,799,923 (+)	NCBI
Rnor_6.0	16	73,584,521 - 73,596,793 (+)	NCBI
Rnor_5.0	16	73,218,686 - 73,230,611 (+)	NCBI
RGSC_v3.4	16	73,245,883 - 73,257,267 (+)	RGD
Celera	16	66,679,100 - 66,691,881 (+)	RGD

Sequence:

show sequence

GTCTCCGGAGTTATTTCAGAGAGAGCTCCCGCGCCTACCTCTCGTGGAGCCTCCGCCTGTGGTG
CGAGCGTGAGGGCTGGGAGAGAACGGAAGAGGAATTCCCACGCCGTGTACCCGCTTTAAGTGCC
TATTACGAGGTGTAGGTTCCTGGTTCAGAAACGATGACAGAGGTTCAGGATCTCCATGGACAGG
ACTCTGATGAGGGTAGTGAGGAGGTGGTCCTAACTCCTGCAGAACTTATTGAAAGGCTGGAGCA
GGCCTGGATGAATGAAAAGTTTGCCCCTGAGCTCCTGGAGAGCAAGTCTGAGATTGTGGAATGT
GTCATGGAGCAGCTAGAGCACATGGAAGAAAATCTCAGAAGAGCCAAGAAGGGCGATCTGAAGG
TCAGTATCCACCGAATGGAGATGGAGAGGATCCGCTATGTCCTTAGCAGCTATTTACGGTGTCG
ACTCATGAAGATAGAGAAGTTTTTCCCTCACATCCTAGAAAAGGAGAAAACGCGCCCTGCGGGG
GAGCCTTCCAGCCTGTCTCCAGAGGAGTTTGTCTTTGCCAAAGAGTATATGGATCACACAGAGA
CCCATTTTAAAAACGTTGCCTTAAAGCACATGCCTCCCAACCTGCAGAAAGTGGACCTCATGAG
GGCAGTTCCCAAACCAGACCTAGATTCATACGTGTTTCTGAGAGTGAAAGAACGACAGGAAAAC
ATACTAGTAGAACCAGAAGCTGATGAGCAGAGAGACTATGTTATTGACTTGGAGGAGGGCTCAC
AGCACTTGATTCGATACAAAACCATTGCACCTCTTGTTGCTTCTGGAGCAGTTCAGTTGATATA
AAACAAAGCAAGCCTAAGAACGTGGACTCATAGACAATAGTGAAACTCCACCTCCTTTTGTGTG
AAGTCATGTTACAGTTCGTCAGCAACTCGTGGACCGCATGGACACGGAAAAGGAGTCAAGCCAG
GACTCCTTTGTTGCCATGCCCTTCTCCTAGATCTGTTTAACCAGGACCAACAGATGGGGCCCTG
CTCTTTATACTCAGTAAATAAATCAACTGTCAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006253313 ⟹ XP_006253375

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	75,489,993 - 75,502,455 (+)	NCBI
mRatBN7.2	16	68,787,572 - 68,799,929 (+)	NCBI
Rnor_6.0	16	73,584,412 - 73,596,808 (+)	NCBI
Rnor_5.0	16	73,218,686 - 73,230,611 (+)	NCBI

Sequence:

show sequence

TAAGACTGATTGGTTAGTGCTCTCTCAGCGCAGGGATGTTTCCGGTTGACGCTGTGTTTCGGAA
AGGAGCGCGGGAGCTGCTCAGGCGGAGGTCTGGTCGGTGGGTGCGGTCTCCGGAGTTATTTCAG
AGAGAGCTCCCGCGCCTACCTCTCGTGGAGCCTCCGCCTGTGGTGCGAGCGTGAGGGCTGGGAG
AGAACGGAAGAGGAATTCCCACGCCGTGTACCCGCTTTAAGTGCCTATTGCGAGGTGTAGGTTC
CTGGTTCAGAAACGATGACAGAGGTTCTGGATCTCCATGGACAGGACTCTGATGAGGGTAGTGA
GGAGGTGGTCCTAACTCCTGCAGAACTCATTGAAAGGCTGGAGCAGGCCTGGATGAATGAAAAG
TTTGCCCCTGAGCTCCTGGAGAGCAAGTCTGAGATTGTGGAATGTGTCGTGGAGCAGCTAGAGC
ACATGGAAGAAAATCTCAGAAGAGCCAAGAAGGGCGATCTGAAGATAGAGAAGTTTTTCCCTCA
CATCCTAGAAAAGGAGAAAACGCGCCCTGCGGGGGAGCCTTCCAGCCTGTCTCCAGAGGAGTTT
GTCTTTGCCAAAGAGTATATGGATCACACAGAGACCCATTTTAAAAACGTTGCCTTAAAGCACA
TGCCTCCCAACCTGCAGAAAGTGGACCTCATGAGGGCAGTTCCCAAACCAGACCTAGATTCATA
CGTGTTTCTGAGAGTGAAAGAACGACAGGAAAACATACTAGTAGAACCAGAAGCTGATGAGCAG
AGAGACTATGTTATTGACTTGGAGGAGGGCTCACAGCACTTGATTCGATACAAAACCATTGCAC
CTCTTGTTGCTTCTGGAGCAGTTCAGTTGATATAAAACAAAGCAAGCCTAAGAACGTGGACTCA
TAGACAATAGTGAAACTCCACCTCCTTTTGTGTGAAGTCATGTTACAGTTCGTCAGCAACTCGT
GGACCGCATGGACACGGAAAAGGAGTCAAGCCAGGACTCCTTTGTTGCCATGCCCTTCTCCTAG
ATCTGTTTAACCAGGACCAACAGATGGGGCCCTGCTCTTTATACTCAGTAAATAAATCAACTGT
CGGTGTGTGCCTTTTA

hide sequence

RefSeq Acc Id:

XM_063275250 ⟹ XP_063131320

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	75,489,990 - 75,502,195 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001025198	(Get FASTA)	NCBI Sequence Viewer
	XP_006253375	(Get FASTA)	NCBI Sequence Viewer
	XP_063131320	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99741	(Get FASTA)	NCBI Sequence Viewer
	EDM09030	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024301
	ENSRNOP00000024301.3
	ENSRNOP00000084853.1
	ENSRNOP00000089454.1
	ENSRNOP00055011444
	ENSRNOP00065010693
GenBank Protein	Q499W2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001025198 ⟸ NM_001030027

- UniProtKB:

Q499W2 (UniProtKB/Swiss-Prot), A6IW42 (UniProtKB/TrEMBL), G3V8B5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTEVQDLHGQDSDEGSEEVVLTPAELIERLEQAWMNEKFAPELLESKSEIVECVMEQLEHMEEN
LRRAKKGDLKVSIHRMEMERIRYVLSSYLRCRLMKIEKFFPHILEKEKTRPAGEPSSLSPEEFV
FAKEYMDHTETHFKNVALKHMPPNLQKVDLMRAVPKPDLDSYVFLRVKERQENILVEPEADEQR
DYVIDLEEGSQHLIRYKTIAPLVASGAVQLI

hide sequence

RefSeq Acc Id:	XP_006253375 ⟸ XM_006253313
- Peptide Label:	isoform X1
- UniProtKB:	A6IW42 (UniProtKB/TrEMBL), G3V8B5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTEVLDLHGQDSDEGSEEVVLTPAELIERLEQAWMNEKFAPELLESKSEIVECVVEQLEHMEEN LRRAKKGDLKIEKFFPHILEKEKTRPAGEPSSLSPEEFVFAKEYMDHTETHFKNVALKHMPPNL QKVDLMRAVPKPDLDSYVFLRVKERQENILVEPEADEQRDYVIDLEEGSQHLIRYKTIAPLVAS GAVQLI hide sequence

RefSeq Acc Id:

ENSRNOP00000024301 ⟸ ENSRNOT00000024301

RefSeq Acc Id:

ENSRNOP00000084853 ⟸ ENSRNOT00000114555

RefSeq Acc Id:

ENSRNOP00000089454 ⟸ ENSRNOT00000111646

RefSeq Acc Id:	XP_063131320 ⟸ XM_063275250
- Peptide Label:	isoform X2

Protein Domains

DNA replication complex GINS protein SLD5 C- GINS subunit

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q499W2-F1-model_v2	AlphaFold	Q499W2	1-223	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700180

Promoter ID:

EPDNEW_R10704

Type:

initiation region

Name:

Gins4_1

Description:

GINS complex subunit 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	73,584,449 - 73,584,509	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307397	AgrOrtholog
BioCyc Gene	G2FUF-10900	BioCyc
Ensembl Genes	ENSRNOG00000018040	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055008424	UniProtKB/Swiss-Prot
	ENSRNOG00065008932	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000024301	ENTREZGENE
	ENSRNOT00000024301.5	UniProtKB/TrEMBL
	ENSRNOT00000111646.1	UniProtKB/TrEMBL
	ENSRNOT00000114555.1	UniProtKB/TrEMBL
	ENSRNOT00055014253	UniProtKB/Swiss-Prot
	ENSRNOT00065014280	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.58.1030	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.5.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5623828	IMAGE-MGC_LOAD
InterPro	GINS_A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GINS_bundle-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GINS_Sld5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SLD5_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sld5_GINS_A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:290842	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124661	IMAGE-MGC_LOAD
NCBI Gene	290842	ENTREZGENE
PANTHER	DNA REPLICATION COMPLEX GINS PROTEIN SLD5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR21206	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Sld5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SLD5_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gins4	PhenoGen
PIRSF	Sld5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018040	RatGTEx
	ENSRNOG00055008424	RatGTEx
	ENSRNOG00065008932	RatGTEx
Superfamily-SCOP	PriA/YqbF domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF158573	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A247_RAT	UniProtKB/TrEMBL
	A0A8I6A7B1_RAT	UniProtKB/TrEMBL
	A6IW42	ENTREZGENE, UniProtKB/TrEMBL
	G3V8B5	ENTREZGENE, UniProtKB/TrEMBL
	Q499W2	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-29	Gins4	GINS complex subunit 4	Gins4	GINS complex subunit 4 (Sld5 homolog)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Gins4	GINS complex subunit 4 (Sld5 homolog)	RGD1307397	similar to RIKEN cDNA 2810037C03	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1307397	similar to RIKEN cDNA 2810037C03	RGD1307397_predicted	similar to RIKEN cDNA 2810037C03 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1307397_predicted	similar to RIKEN cDNA 2810037C03 (predicted)	LOC290842_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC290842_predicted	similar to RIKEN cDNA 2810037C03 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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