Chtf8 (chromosome transmission fidelity factor 8) - Rat Genome Database

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Gene: Chtf8 (chromosome transmission fidelity factor 8) Rattus norvegicus
Analyze
Symbol: Chtf8
Name: chromosome transmission fidelity factor 8
RGD ID: 1306894
Description: Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in DNA duplex unwinding; DNA replication; and mitotic sister chromatid cohesion. Predicted to be part of Ctf18 RFC-like complex. Orthologous to human CHTF8 (chromosome transmission fidelity factor 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cocaine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromosome transmission fidelity factor 8 homolog; chromosome transmission fidelity factor 8 homolog (S. cerevisiae); chromosome transmission fidelity protein 8 homolog; Ctf8; CTF8, chromosome transmission fidelity factor 8 homolog; CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae); Derpc; LOC364996; RGD1306894; similar to CoLlagen sequence X-hybridizing family member (clx-1); similar to RIKEN cDNA 5830457O10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,691,776 - 51,702,076 (-)NCBIGRCr8
mRatBN7.21934,782,005 - 34,792,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,781,856 - 34,792,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1941,597,525 - 41,607,825 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,250,865 - 42,261,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,549,989 - 44,560,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01939,077,580 - 39,087,880 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,077,580 - 39,087,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,941,868 - 49,952,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,731,970 - 36,734,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,736,621 - 36,741,549 (-)NCBI
Celera1934,206,017 - 34,216,317 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12930902   PMID:15057822   PMID:23533145   PMID:29476059  


Genomics

Comparative Map Data
Chtf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,691,776 - 51,702,076 (-)NCBIGRCr8
mRatBN7.21934,782,005 - 34,792,306 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,781,856 - 34,792,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1941,597,525 - 41,607,825 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,250,865 - 42,261,165 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,549,989 - 44,560,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01939,077,580 - 39,087,880 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,077,580 - 39,087,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,941,868 - 49,952,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,731,970 - 36,734,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,736,621 - 36,741,549 (-)NCBI
Celera1934,206,017 - 34,216,317 (-)NCBICelera
Cytogenetic Map19q12NCBI
CHTF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,118,010 - 69,132,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,118,010 - 69,132,588 (-)EnsemblGRCh38hg38GRCh38
GRCh371669,151,913 - 69,166,491 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,709,414 - 67,723,985 (-)NCBINCBI36Build 36hg18NCBI36
Celera1653,661,235 - 53,675,816 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,024,647 - 55,039,230 (-)NCBIHuRef
CHM1_11670,559,986 - 70,574,568 (-)NCBICHM1_1
T2T-CHM13v2.01674,914,320 - 74,928,895 (-)NCBIT2T-CHM13v2.0
Chtf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,610,495 - 107,620,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8107,610,495 - 107,620,233 (-)EnsemblGRCm39 Ensembl
GRCm388106,883,863 - 106,893,593 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,883,863 - 106,893,601 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,883,890 - 106,893,593 (-)EnsemblGRCm38mm10GRCm38
MGSCv378109,407,763 - 109,417,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368109,772,992 - 109,782,722 (-)NCBIMGSCv36mm8
Celera8111,109,761 - 111,119,489 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.3NCBI
Chtf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554847,539,887 - 7,542,395 (+)NCBIChiLan1.0ChiLan1.0
DERPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,659,322 - 78,661,730 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,570,921 - 84,573,329 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,489,176 - 49,503,740 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11668,877,028 - 68,892,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,877,028 - 68,891,513 (-)Ensemblpanpan1.1panPan2
CHTF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,510,617 - 80,521,356 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,509,002 - 80,520,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha580,500,499 - 80,509,750 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,944,026 - 80,953,277 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,943,583 - 80,954,117 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,771,246 - 80,780,496 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0580,453,796 - 80,463,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,093,717 - 81,102,968 (+)NCBIUU_Cfam_GSD_1.0
Chtf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,303,377 - 40,304,909 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647519,282,195 - 19,285,735 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647519,282,226 - 19,285,758 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DERPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,275,047 - 58,289,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl558,274,678 - 58,286,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604721,008,343 - 21,022,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chtf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474617,206,000 - 17,217,856 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474617,206,003 - 17,218,678 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chtf8
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:808
Count of miRNA genes:302
Interacting mature miRNAs:386
Transcripts:ENSRNOT00000070822
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
RH129659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,782,242 - 34,782,394 (+)MAPPERmRatBN7.2
Rnor_6.01939,077,818 - 39,077,969NCBIRnor6.0
Rnor_5.01949,942,106 - 49,942,257UniSTSRnor5.0
RGSC_v3.41936,731,979 - 36,732,130UniSTSRGSC3.4
Celera1934,206,255 - 34,206,406UniSTS
RH 3.4 Map19294.7UniSTS
Cytogenetic Map19q12UniSTS
RH143420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,782,106 - 34,782,252 (+)MAPPERmRatBN7.2
Rnor_6.01939,077,682 - 39,077,827NCBIRnor6.0
Rnor_5.01949,941,970 - 49,942,115UniSTSRnor5.0
RGSC_v3.41936,731,843 - 36,731,988UniSTSRGSC3.4
Celera1934,206,119 - 34,206,264UniSTS
RH 3.4 Map19295.5UniSTS
Cytogenetic Map19q12UniSTS
AI535550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,789,996 - 34,790,202 (+)MAPPERmRatBN7.2
Rnor_6.01939,085,571 - 39,085,776NCBIRnor6.0
Rnor_5.01949,949,859 - 49,950,064UniSTSRnor5.0
RGSC_v3.41936,739,732 - 36,739,937UniSTSRGSC3.4
Celera1934,214,008 - 34,214,213UniSTS
RH 3.4 Map19293.7UniSTS
Cytogenetic Map19q12UniSTS
AI008492  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21934,782,401 - 34,782,588 (+)MAPPERmRatBN7.2
Rnor_6.01939,077,977 - 39,078,163NCBIRnor6.0
Rnor_5.01949,942,265 - 49,942,451UniSTSRnor5.0
RGSC_v3.41936,732,138 - 36,732,324UniSTSRGSC3.4
Celera1934,206,414 - 34,206,600UniSTS
RH 3.4 Map19292.9UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 1 2 74 35 41 11 1
Low 7 7 9 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000070822   ⟹   ENSRNOP00000063969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,781,856 - 34,792,578 (-)Ensembl
Rnor_6.0 Ensembl1939,077,580 - 39,087,880 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111805   ⟹   ENSRNOP00000096000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1934,782,201 - 34,786,234 (-)Ensembl
RefSeq Acc Id: NM_001194951   ⟹   NP_001181880
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81951,691,776 - 51,702,076 (-)NCBI
mRatBN7.21934,782,005 - 34,792,306 (-)NCBI
Rnor_6.01939,077,580 - 39,087,880 (-)NCBI
Rnor_5.01949,941,868 - 49,952,168 (-)NCBI
Celera1934,206,017 - 34,216,317 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001181880 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92458 (Get FASTA)   NCBI Sequence Viewer  
  P0C6T1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001181880   ⟸   NM_001194951
- UniProtKB: P0C6T1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063969   ⟸   ENSRNOT00000070822
RefSeq Acc Id: ENSRNOP00000096000   ⟸   ENSRNOT00000111805

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C6T1-F1-model_v2 AlphaFold P0C6T1 1-121 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701115
Promoter ID:EPDNEW_R11639
Type:multiple initiation site
Name:Chtf8_1
Description:chromosome transmission fidelity factor 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01939,087,958 - 39,088,018EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306894 AgrOrtholog
BioCyc Gene G2FUF-5774 BioCyc
Ensembl Genes ENSRNOG00000047246 Ensembl
IMAGE_CLONE IMAGE:8367310 IMAGE-MGC_LOAD
InterPro Ctf8 UniProtKB/Swiss-Prot
KEGG Report rno:364996 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188691 IMAGE-MGC_LOAD
NCBI Gene 364996 ENTREZGENE
PANTHER CHROMOSOME TRANSMISSION FIDELITY PROTEIN 8 HOMOLOG UniProtKB/Swiss-Prot
  CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE) UniProtKB/Swiss-Prot
Pfam Ctf8 UniProtKB/Swiss-Prot
PhenoGen Chtf8 PhenoGen
RatGTEx ENSRNOG00000047246 RatGTEx
UniProt CTF8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-24 Chtf8  chromosome transmission fidelity factor 8  Chtf8  CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Chtf8  CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)  LOC690176  similar to CoLlagen sequence X-hybridizing family member (clx-1)  Data merged from RGD:1583996 1643240 APPROVED
2009-02-23 Chtf8  CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)  Ctf8  chromosome transmission fidelity factor 8 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Ctf8  chromosome transmission fidelity factor 8 homolog (S. cerevisiae)  RGD1306894_predicted  similar to RIKEN cDNA 5830457O10 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC690176  similar to CoLlagen sequence X-hybridizing family member (clx-1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1306894_predicted  similar to RIKEN cDNA 5830457O10 (predicted)  LOC364996_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364996_predicted  similar to RIKEN cDNA 5830457O10 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL