Stim1 (stromal interaction molecule 1) - Rat Genome Database

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Gene: Stim1 (stromal interaction molecule 1) Rattus norvegicus
Symbol: Stim1
Name: stromal interaction molecule 1
RGD ID: 1306831
Description: Enables calcium channel regulator activity and store-operated calcium channel activity. Involved in activation of store-operated calcium channel activity; regulation of store-operated calcium entry; and store-operated calcium entry. Located in growth cone. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: LOC361618
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21156,656,246 - 156,818,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,656,013 - 156,818,363 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,634,178 - 164,796,508 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01171,814,265 - 171,976,603 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01164,691,930 - 164,854,456 (+)NCBIRnor_WKY
Rnor_6.01167,373,894 - 167,533,412 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,373,678 - 167,533,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,562,261 - 173,722,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,761,567 - 159,925,836 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,840,391 - 160,004,859 (+)NCBI
Celera1154,724,106 - 154,885,972 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
caffeine  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
clozapine  (ISO)
corosolic acid  (EXP)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenzo[a,l]pyrene  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
genistein  (ISO)
glucose  (EXP)
indometacin  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lithocholic acid  (EXP)
methamphetamine  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
Monobutylphthalate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rotenone  (ISO)
SKF-96365 hydrochloride  (EXP)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
usnic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. RNA interference targeting STIM1 suppresses vascular smooth muscle cell proliferation and neointima formation in the rat. Aubart FC, etal., Mol Ther. 2009 Mar;17(3):455-62. doi: 10.1038/mt.2008.291. Epub 2008 Dec 23.
2. Plasma Long Non-Coding RNA RP11-438N5.3 as a Novel Biomarker for Non-Small Cell Lung Cancer. Chen Q, etal., Cancer Manag Res. 2020 Feb 28;12:1513-1521. doi: 10.2147/CMAR.S237024. eCollection 2020.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. Gemes G, etal., J Neurosci. 2011 Mar 9;31(10):3536-49.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. Gruszczynska-Biegala J, etal., PLoS One. 2011 Apr 26;6(4):e19285.
7. Defective Store-Operated Calcium Entry Causes Partial Nephrogenic Diabetes Insipidus. Mamenko M, etal., J Am Soc Nephrol. 2016 Jul;27(7):2035-48. doi: 10.1681/ASN.2014121200. Epub 2015 Nov 16.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. STIM1 is necessary for store-operated calcium entry in turning growth cones. Mitchell CB, etal., J Neurochem. 2012 Sep;122(6):1155-66. doi: 10.1111/j.1471-4159.2012.07840.x. Epub 2012 Jul 11.
10. A nonsense mutation of Stim1 identified in stroke-prone spontaneously hypertensive rats decreased the store-operated calcium entry in astrocytes. Ohara H and Nabika T, Biochem Biophys Res Commun. 2016 Aug 5;476(4):406-411. doi: 10.1016/j.bbrc.2016.05.134. Epub 2016 May 27.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. STIM proteins: dynamic calcium signal transducers. Soboloff J, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):549-65. doi: 10.1038/nrm3414.
16. STIM1 silencing inhibits the migration and invasion of A549 cells. Wang Y, etal., Mol Med Rep. 2017 Sep;16(3):3283-3289. doi: 10.3892/mmr.2017.7010. Epub 2017 Jul 15.
17. Elevated expression of STIM1 is involved in lung tumorigenesis. Wang Y, etal., Oncotarget. 2016 Dec 27;7(52):86584-86593. doi: 10.18632/oncotarget.13359.
18. EB virus promotes metastatic potential by boosting STIM1-dependent Ca2+ signaling in nasopharyngeal carcinoma cells. Wei J, etal., Cancer Lett. 2020 May 28;478:122-132. doi: 10.1016/j.canlet.2020.03.005. Epub 2020 Mar 9.
19. Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer. Xia J, etal., Cancer Lett. 2016 Oct 10;381(1):31-40. doi: 10.1016/j.canlet.2016.07.014. Epub 2016 Jul 16.
20. Stromal interaction molecule 1 plays an important role in gastric cancer progression. Xu JM, etal., Oncol Rep. 2016 Jun;35(6):3496-504. doi: 10.3892/or.2016.4704. Epub 2016 Mar 24.
21. Blockade of store-operated Ca(2+) entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover. Yang N, etal., Cancer Lett. 2013 Apr 28;330(2):163-9. doi: 10.1016/j.canlet.2012.11.040. Epub 2012 Dec 2.
22. Inhibition of stromal-interacting molecule 1-mediated store-operated Ca2+ entry as a novel strategy for the treatment of acquired imatinib-resistant gastrointestinal stromal tumors. Yang Z, etal., Cancer Sci. 2018 Sep;109(9):2792-2800. doi: 10.1111/cas.13718. Epub 2018 Jul 28.
23. STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma. Zhao H, etal., Theranostics. 2020 May 16;10(14):6483-6499. doi: 10.7150/thno.44025. eCollection 2020.
24. Immune-related genes STIM1, ITPKC and PELI1 polymorphisms are associated with risk of colorectal cancer. Zhu L, etal., Eur J Cancer Prev. 2021 Sep 1;30(5):357-363. doi: 10.1097/CEJ.0000000000000641.
Additional References at PubMed
PMID:12477932   PMID:15057822   PMID:16005298   PMID:16208375   PMID:16766533   PMID:17224452   PMID:17343823   PMID:17432954   PMID:17517596   PMID:17647013   PMID:18250430   PMID:18424621  
PMID:18768920   PMID:18845811   PMID:18987344   PMID:19052075   PMID:19075091   PMID:19171672   PMID:19189966   PMID:19249086   PMID:19364762   PMID:19395668   PMID:19632184   PMID:19715666  
PMID:20037597   PMID:20107038   PMID:20138887   PMID:20404049   PMID:20418871   PMID:20599714   PMID:20929813   PMID:21330611   PMID:21427704   PMID:21750194   PMID:21810664   PMID:21906591  
PMID:21966957   PMID:22050845   PMID:22108917   PMID:22451904   PMID:22547346   PMID:22586105   PMID:22684549   PMID:22944608   PMID:22992728   PMID:23206701   PMID:23261659   PMID:23289723  
PMID:23332920   PMID:23334602   PMID:23542055   PMID:23711249   PMID:23840669   PMID:23878392   PMID:24509424   PMID:24621671   PMID:24736434   PMID:24894994   PMID:24996186   PMID:25063063  
PMID:25326555   PMID:25384971   PMID:25636074   PMID:26033013   PMID:26261328   PMID:26322679   PMID:26694763   PMID:26960935   PMID:27025854   PMID:27185316   PMID:27503411   PMID:27601731  
PMID:28105751   PMID:28155613   PMID:28219928   PMID:28402855   PMID:29089467   PMID:29110214   PMID:29532875   PMID:29634917   PMID:29704510   PMID:29804005   PMID:30589833   PMID:31009360  
PMID:31009446   PMID:31023836   PMID:31036675   PMID:31936514   PMID:32300198   PMID:32700574   PMID:33341060   PMID:33484198   PMID:34173958   PMID:34685680   PMID:34995919  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21156,656,246 - 156,818,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,656,013 - 156,818,363 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,634,178 - 164,796,508 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01171,814,265 - 171,976,603 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01164,691,930 - 164,854,456 (+)NCBIRnor_WKY
Rnor_6.01167,373,894 - 167,533,412 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,373,678 - 167,533,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,562,261 - 173,722,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,761,567 - 159,925,836 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,840,391 - 160,004,859 (+)NCBI
Celera1154,724,106 - 154,885,972 (+)NCBICelera
Cytogenetic Map1q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38113,854,604 - 4,093,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl113,854,527 - 4,093,210 (+)EnsemblGRCh38hg38GRCh38
GRCh37113,875,834 - 4,114,440 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,833,509 - 4,071,015 (+)NCBINCBI36Build 36hg18NCBI36
Build 34113,833,508 - 4,071,015NCBI
Celera113,882,103 - 4,119,396 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,610,828 - 3,847,861 (+)NCBIHuRef
CHM1_1113,876,404 - 4,113,905 (+)NCBICHM1_1
T2T-CHM13v2.0113,919,928 - 4,158,475 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397101,909,279 - 102,086,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,917,013 - 102,086,526 (+)EnsemblGRCm39 Ensembl
GRCm387102,261,514 - 102,437,319 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,267,806 - 102,437,319 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,416,338 - 109,585,374 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367102,141,645 - 102,310,681 (+)NCBIMGSCv36mm8
Celera7102,604,834 - 102,804,802 (+)NCBICelera
Cytogenetic Map7E2- E3NCBI
cM Map754.71NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541419,652,990 - 19,847,964 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,652,990 - 19,849,353 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1115,313,095 - 5,588,264 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0113,726,501 - 3,954,951 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1113,839,958 - 4,066,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl113,840,513 - 4,065,224 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12126,394,592 - 26,594,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,394,811 - 26,593,375 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,165,634 - 26,364,115 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,605,233 - 26,804,185 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,604,981 - 26,804,177 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,396,567 - 26,594,567 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,612,342 - 26,810,837 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,514,667 - 26,713,342 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494759,250,243 - 59,464,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936498849,739 - 1,063,552 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936498849,775 - 1,063,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl96,066,617 - 6,270,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,066,612 - 6,270,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.296,848,913 - 7,055,195 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1162,651,472 - 62,865,992 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl162,651,290 - 62,865,986 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604363,036,418 - 63,251,216 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248175,291,717 - 5,522,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248175,291,111 - 5,522,732 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Stim1
554 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:133
Interacting mature miRNAs:167
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,677,124 - 156,677,310 (+)MAPPERmRatBN7.2
Rnor_6.01167,394,665 - 167,394,850NCBIRnor6.0
Rnor_5.01173,583,273 - 173,583,458UniSTSRnor5.0
RGSC_v3.41159,782,445 - 159,782,631RGDRGSC3.4
RGSC_v3.41159,782,446 - 159,782,631UniSTSRGSC3.4
RGSC_v3.11159,861,463 - 159,861,648RGD
Celera1154,744,974 - 154,745,153UniSTS
RH 3.4 Map11281.6RGD
RH 3.4 Map11281.6UniSTS
SHRSP x BN Map179.01UniSTS
SHRSP x BN Map179.01RGD
FHH x ACI Map172.14RGD
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,801,485 - 156,801,626 (+)MAPPERmRatBN7.2
Rnor_6.01167,516,174 - 167,516,312NCBIRnor6.0
Rnor_5.01173,704,782 - 173,704,920UniSTSRnor5.0
RGSC_v3.41159,908,544 - 159,908,683RGDRGSC3.4
RGSC_v3.41159,908,545 - 159,908,683UniSTSRGSC3.4
RGSC_v3.11159,987,562 - 159,987,700RGD
Celera1154,868,693 - 154,868,808UniSTS
RH 3.4 Map11285.6UniSTS
RH 3.4 Map11285.6RGD
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,696,131 - 156,697,074 (+)MAPPERmRatBN7.2
mRatBN7.21062,202,385 - 62,202,577 (-)MAPPERmRatBN7.2
Rnor_6.01167,413,466 - 167,414,408NCBIRnor6.0
Rnor_6.01062,809,569 - 62,809,760NCBIRnor6.0
Rnor_5.01062,507,061 - 62,507,252UniSTSRnor5.0
Rnor_5.01173,602,074 - 173,603,016UniSTSRnor5.0
Cytogenetic Map10q26UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,817,358 - 156,818,262 (+)MAPPERmRatBN7.2
Rnor_6.01167,531,992 - 167,532,895NCBIRnor6.0
Rnor_5.01173,720,600 - 173,721,503UniSTSRnor5.0
RGSC_v3.41159,924,416 - 159,925,319UniSTSRGSC3.4
Celera1154,884,552 - 154,885,455UniSTS
Cytogenetic Map1q32UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 28 52 39 19 39 8 11 64 22 34 11 8
Low 15 5 2 2 10 13 7
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027685   ⟹   ENSRNOP00000027685
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,656,013 - 156,818,363 (+)Ensembl
Rnor_6.0 Ensembl1167,373,678 - 167,532,970 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088370   ⟹   ENSRNOP00000073378
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,656,013 - 156,813,307 (+)Ensembl
Rnor_6.0 Ensembl1167,373,682 - 167,533,420 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092882   ⟹   ENSRNOP00000075979
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,656,013 - 156,817,374 (+)Ensembl
Rnor_6.0 Ensembl1167,374,182 - 167,532,007 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092987   ⟹   ENSRNOP00000075934
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1167,522,895 - 167,532,012 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093012
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1167,519,747 - 167,522,860 (+)Ensembl
RefSeq Acc Id: NM_001108496   ⟹   NP_001101966
Rat AssemblyChrPosition (strand)Source
mRatBN7.21156,656,246 - 156,818,777 (+)NCBI
Rnor_6.01167,373,894 - 167,533,412 (+)NCBI
Rnor_5.01173,562,261 - 173,722,026 (+)NCBI
RGSC_v3.41159,761,567 - 159,925,836 (+)RGD
Celera1154,724,106 - 154,885,972 (+)RGD
Reference Sequences
RefSeq Acc Id: NP_001101966   ⟸   NM_001108496
- Peptide Label: precursor
- UniProtKB: P84903 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075979   ⟸   ENSRNOT00000092882
RefSeq Acc Id: ENSRNOP00000075934   ⟸   ENSRNOT00000092987
RefSeq Acc Id: ENSRNOP00000073378   ⟸   ENSRNOT00000088370
RefSeq Acc Id: ENSRNOP00000027685   ⟸   ENSRNOT00000027685
Protein Domains
EF-hand   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84903-F1-model_v2 AlphaFold P84903 1-685 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690270
Promoter ID:EPDNEW_R794
Type:initiation region
Description:stromal interaction molecule 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01167,373,665 - 167,373,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306831 AgrOrtholog
BioCyc Gene G2FUF-58249 BioCyc
Ensembl Genes ENSRNOG00000020425 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027685.5 UniProtKB/TrEMBL
  ENSRNOP00000073378.2 UniProtKB/TrEMBL
  ENSRNOP00000075979.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027685.6 UniProtKB/TrEMBL
  ENSRNOT00000088370.2 UniProtKB/TrEMBL
  ENSRNOT00000092882.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STIM1_SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361618 UniProtKB/Swiss-Prot
PANTHER PTHR15136 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15136:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stim1 PhenoGen
SMART SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5C8_RAT UniProtKB/TrEMBL
  P84903 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Stim1  stromal interaction molecule 1   Stim1_predicted  stromal interaction molecule 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stim1_predicted  stromal interaction molecule 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED