Gene: Map3k5 (mitogen-activated protein kinase kinase kinase 5) Rattus norvegicus
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Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity; ATP binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to tumor necrosis factor; endothelial cell apoptotic process; positive regulation of cardiac muscle cell apoptotic process; PARTICIPATES IN p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH Carotid Artery Injuries; cerebral infarction; Hypoxia-Ischemia, Brain; FOUND IN cytoplasm; cytosol; external side of plasma membrane; INTERACTS WITH 17beta-estradiol; 4-vinylcyclohexene dioxide; 6-propyl-2-thiouracil
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis signal regulating kinase 1; Ask1; LOC365057; RGD1306565; similar to apoptosis signal-regulating kinase 1
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0115,412,603 - 15,613,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0116,961,080 - 17,160,996 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4115,205,361 - 15,346,422 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1115,204,326 - 15,346,541 (+)NCBI
Celera113,127,308 - 13,336,631 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Map3k5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306565
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE