Elp2 (elongator acetyltransferase complex subunit 2) - Rat Genome Database

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Gene: Elp2 (elongator acetyltransferase complex subunit 2) Rattus norvegicus
Analyze
Symbol: Elp2
Name: elongator acetyltransferase complex subunit 2
RGD ID: 1306419
Description: Predicted to enable protein kinase binding activity. Predicted to contribute to RNA polymerase II complex binding activity. Predicted to be involved in tRNA wobble uridine modification. Predicted to act upstream of or within regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of elongator holoenzyme complex and transcription elongation factor complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 58. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: elongation protein 2 homolog; elongation protein 2 homolog (S. cerevisiae); elongator complex protein 2; LOC307545; MGC124711; SHINC-2; signal transducer and activator of transcription interacting protein 1; STAT3-interacting protein; STAT3-interacting protein 1; Statip1; stIP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,885,940 - 15,921,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1815,885,934 - 15,921,599 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1816,073,244 - 16,107,200 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01816,855,950 - 16,889,907 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01816,144,159 - 16,178,175 (+)NCBIRnor_WKY
Rnor_6.01816,544,515 - 16,581,086 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1816,544,508 - 16,581,116 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01816,303,458 - 16,340,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01816,519,807 - 16,520,203 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41816,374,790 - 16,410,413 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11816,401,461 - 16,437,098 (+)NCBI
Celera1815,815,058 - 15,849,358 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10954736   PMID:11714725   PMID:12477932   PMID:15489334   PMID:22854966  


Genomics

Comparative Map Data
Elp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21815,885,940 - 15,921,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1815,885,934 - 15,921,599 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1816,073,244 - 16,107,200 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01816,855,950 - 16,889,907 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01816,144,159 - 16,178,175 (+)NCBIRnor_WKY
Rnor_6.01816,544,515 - 16,581,086 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1816,544,508 - 16,581,116 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01816,303,458 - 16,340,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01816,519,807 - 16,520,203 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41816,374,790 - 16,410,413 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11816,401,461 - 16,437,098 (+)NCBI
Celera1815,815,058 - 15,849,358 (+)NCBICelera
Cytogenetic Map18p12NCBI
ELP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381836,129,899 - 36,180,557 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1836,129,444 - 36,180,557 (+)EnsemblGRCh38hg38GRCh38
GRCh371833,709,862 - 33,760,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361831,963,885 - 32,008,605 (+)NCBINCBI36Build 36hg18NCBI36
Build 341831,963,884 - 32,008,605NCBI
Celera1830,517,767 - 30,562,479 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
HuRef1830,568,753 - 30,613,587 (+)NCBIHuRef
CHM1_11833,636,918 - 33,681,799 (+)NCBICHM1_1
T2T-CHM13v2.01836,321,463 - 36,372,122 (+)NCBIT2T-CHM13v2.0
Elp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391824,737,018 - 24,771,887 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1824,735,923 - 24,772,564 (+)EnsemblGRCm39 Ensembl
GRCm381824,603,961 - 24,638,830 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1824,602,866 - 24,639,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv371824,762,462 - 24,797,331 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361824,747,005 - 24,781,820 (+)NCBIMGSCv36mm8
Celera1825,085,876 - 25,120,732 (+)NCBICelera
Cytogenetic Map18A2NCBI
Elp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540222,698,881 - 22,742,615 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540222,698,817 - 22,742,691 (+)NCBIChiLan1.0ChiLan1.0
ELP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11839,217,955 - 39,266,518 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01829,382,531 - 29,428,212 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11832,941,125 - 32,986,191 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1832,941,122 - 32,986,191 (+)Ensemblpanpan1.1panPan2
ELP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1754,010,628 - 54,059,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl754,011,577 - 54,059,887 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha753,436,080 - 53,484,643 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0753,980,733 - 54,029,402 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl753,980,687 - 54,029,900 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1753,663,970 - 53,712,535 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0753,687,429 - 53,735,915 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0753,979,910 - 54,028,562 (-)NCBIUU_Cfam_GSD_1.0
Elp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494449,790,330 - 49,839,475 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365179,117,730 - 9,166,861 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6119,885,463 - 119,932,123 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16119,885,409 - 119,932,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26112,411,612 - 112,458,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ELP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11844,640,636 - 44,680,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1844,636,318 - 44,681,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605019,100,768 - 19,141,245 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477910,434,092 - 10,477,098 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477910,434,022 - 10,477,844 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Elp2
275 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:40
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000020601
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020601   ⟹   ENSRNOP00000020601
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1815,885,934 - 15,921,599 (+)Ensembl
Rnor_6.0 Ensembl1816,544,508 - 16,581,116 (+)Ensembl
RefSeq Acc Id: NM_001034145   ⟹   NP_001029317
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21815,885,940 - 15,921,564 (+)NCBI
Rnor_6.01816,544,515 - 16,581,086 (+)NCBI
Rnor_5.01816,519,807 - 16,520,203 (+)NCBI
RGSC_v3.41816,374,790 - 16,410,413 (+)RGD
Celera1815,815,058 - 15,849,358 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001029317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH92606 (Get FASTA)   NCBI Sequence Viewer  
  AAI00662 (Get FASTA)   NCBI Sequence Viewer  
  EDL76140 (Get FASTA)   NCBI Sequence Viewer  
  Q496Z0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001029317   ⟸   NM_001034145
- UniProtKB: Q562B6 (UniProtKB/Swiss-Prot),   Q496Z0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020601   ⟸   ENSRNOT00000020601

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q496Z0-F1-model_v2 AlphaFold Q496Z0 1-821 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700666
Promoter ID:EPDNEW_R11190
Type:initiation region
Name:Elp2_1
Description:elongator acetyltransferase complex subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01816,544,531 - 16,544,591EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306419 AgrOrtholog
BioCyc Gene G2FUF-8145 BioCyc
Ensembl Genes ENSRNOG00000015301 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000020601 ENTREZGENE
  ENSRNOP00000020601.5 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020601 ENTREZGENE
  ENSRNOT00000020601.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7309436 IMAGE-MGC_LOAD
  IMAGE:7935317 IMAGE-MGC_LOAD
InterPro Elp2 UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:307545 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109231 IMAGE-MGC_LOAD
  MGC:124711 IMAGE-MGC_LOAD
NCBI Gene 307545 ENTREZGENE
PANTHER ELONGATOR COMPLEX PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR44111 UniProtKB/Swiss-Prot
Pfam WD40 UniProtKB/Swiss-Prot
PhenoGen Elp2 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt ELP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q562B6 ENTREZGENE
UniProt Secondary Q562B6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-13 Elp2  elongator acetyltransferase complex subunit 2  Elp2  elongation protein 2 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Elp2  elongation protein 2 homolog (S. cerevisiae)  Statip1  signal transducer and activator of transcription interacting protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Statip1  signal transducer and activator of transcription interacting protein 1  Statip1_predicted  signal transducer and activator of transcription interacting protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Statip1_predicted  signal transducer and activator of transcription interacting protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED