Eif4g1 (eukaryotic translation initiation factor 4 gamma, 1) - Rat Genome Database

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Gene: Eif4g1 (eukaryotic translation initiation factor 4 gamma, 1) Rattus norvegicus
Analyze
Symbol: Eif4g1
Name: eukaryotic translation initiation factor 4 gamma, 1
RGD ID: 1306144
Description: Exhibits eukaryotic initiation factor 4E binding activity. Involved in lung development and response to ethanol. Localizes to eukaryotic translation initiation factor 4F complex and postsynapse. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1); PARTICIPATES IN translation initiation pathway; myocarditis pathway; RNA transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; amphetamine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: eukaryotic translation initiation factor 4 gamma 1; eukaryotic translation initiation factor 4 gamma 1-like; LOC100912571; LOC102550847; LOC287986; voltage-dependent P/Q-type calcium channel subunit alpha-1A-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,221,919 - 80,241,958 (-)NCBI
Rnor_6.0 Ensembl1183,908,109 - 83,926,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01183,907,659 - 83,927,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01186,979,577 - 86,999,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,451,555 - 82,471,735 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11182,509,144 - 82,529,350 (-)NCBI
Celera1179,061,657 - 79,081,657 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7-methyl-GTP  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
captan  (ISO)
carbamazepine  (ISO)
chloroprene  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
curcumin  (ISO)
cycloheximide  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
everolimus  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
josamycin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pyrogallol  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP)
Soman  (EXP)
testosterone enanthate  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
torin 1  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12388085   PMID:12477932   PMID:16306159   PMID:16698552   PMID:17117141   PMID:17556672   PMID:18426977   PMID:19648179   PMID:19946888   PMID:21289279   PMID:22006312   PMID:22658674  
PMID:23106098   PMID:23409027   PMID:23814182   PMID:24092755   PMID:24990923   PMID:25255371   PMID:25456498   PMID:25468996   PMID:25533483   PMID:29062139  


Genomics

Comparative Map Data
Eif4g1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,221,919 - 80,241,958 (-)NCBI
Rnor_6.0 Ensembl1183,908,109 - 83,926,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01183,907,659 - 83,927,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01186,979,577 - 86,999,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,451,555 - 82,471,735 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11182,509,144 - 82,529,350 (-)NCBI
Celera1179,061,657 - 79,081,657 (-)NCBICelera
Cytogenetic Map11q23NCBI
EIF4G1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3184,314,495 - 184,335,358 (+)EnsemblGRCh38hg38GRCh38
GRCh383184,314,606 - 184,335,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373184,032,394 - 184,053,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,515,050 - 185,535,840 (+)NCBINCBI36hg18NCBI36
Celera3182,472,966 - 182,494,042 (+)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,439,248 - 181,459,772 (+)NCBIHuRef
CHM1_13183,996,741 - 184,017,602 (+)NCBICHM1_1
Eif4g1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,491,446 - 20,511,633 (+)NCBIGRCm39mm39
GRCm39 Ensembl1620,487,063 - 20,511,634 (+)Ensembl
GRCm381620,672,720 - 20,692,883 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,668,313 - 20,692,884 (+)EnsemblGRCm38mm10GRCm38
MGSCv371620,672,822 - 20,692,956 (+)NCBIGRCm37mm9NCBIm37
MGSCv361620,586,292 - 20,606,426 (+)NCBImm8
Celera1621,237,424 - 21,258,239 (+)NCBICelera
Cytogenetic Map16A3NCBI
Eif4g1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,161,078 - 23,180,568 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,161,541 - 23,179,788 (-)NCBIChiLan1.0ChiLan1.0
EIF4G1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13189,833,575 - 189,854,291 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,833,490 - 189,855,060 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03181,351,938 - 181,372,776 (+)NCBIMhudiblu_PPA_v0panPan3
EIF4G1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,194,588 - 17,214,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,195,562 - 17,214,052 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,280,776 - 21,300,463 (+)NCBI
ROS_Cfam_1.03417,102,466 - 17,122,377 (+)NCBI
UMICH_Zoey_3.13417,139,588 - 17,159,277 (+)NCBI
UNSW_CanFamBas_1.03417,135,671 - 17,155,361 (+)NCBI
UU_Cfam_GSD_1.03417,364,627 - 17,384,317 (+)NCBI
Eif4g1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,456,677 - 119,475,343 (-)NCBI
SpeTri2.0NW_0049365785,548,526 - 5,567,220 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4G1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,203,511 - 122,225,359 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,203,488 - 122,225,371 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,643,301 - 131,665,146 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4G1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,085,326 - 5,106,551 (-)NCBI
ChlSab1.1 Ensembl155,084,780 - 5,105,288 (-)Ensembl
Vero_WHO_p1.0NW_02366606313,862,963 - 13,884,237 (-)NCBI
Eif4g1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473072,251,840 - 72,271,724 (-)NCBI

Position Markers
RH138917  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01173,813,398 - 73,813,536NCBIRnor5.0
Rnor_5.01186,984,353 - 86,984,491NCBIRnor5.0
Rnor_5.01185,970,297 - 85,970,435NCBIRnor5.0
RGSC_v3.41182,456,333 - 82,456,470UniSTSRGSC3.4
RGSC_v3.41169,316,683 - 69,316,820UniSTSRGSC3.4
Celera1179,066,434 - 79,066,571UniSTS
Celera1166,942,233 - 66,942,370UniSTS
RH 3.4 Map20490.34UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116934231986312439Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117272002986994795Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)118035840887200449Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:111
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000040029, ENSRNOT00000041777
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_006221194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000040029   ⟹   ENSRNOP00000040698
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1183,908,109 - 83,926,524 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000041777   ⟹   ENSRNOP00000049629
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1183,908,109 - 83,926,524 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075306   ⟹   ENSRNOP00000067492
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1182,886,878 - 82,893,845 (-)Ensembl
RefSeq Acc Id: XM_006221194   ⟹   XP_006221256
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006221195   ⟹   XP_006221257
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248581   ⟹   XP_006248643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,956 (-)NCBI
Rnor_6.01183,907,659 - 83,927,674 (-)NCBI
Rnor_5.01186,979,577 - 86,999,605 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248583   ⟹   XP_006248645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,958 (-)NCBI
Rnor_6.01183,907,659 - 83,927,674 (-)NCBI
Rnor_5.01186,979,577 - 86,999,605 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248584   ⟹   XP_006248646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,958 (-)NCBI
Rnor_6.01183,907,659 - 83,927,683 (-)NCBI
Rnor_5.01186,979,577 - 86,999,605 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248585   ⟹   XP_006248647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,956 (-)NCBI
Rnor_6.01183,907,659 - 83,927,674 (-)NCBI
Rnor_5.01186,979,577 - 86,999,605 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758181   ⟹   XP_008756403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758184   ⟹   XP_008756406
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758186   ⟹   XP_008756408
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758188   ⟹   XP_008756410
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758195   ⟹   XP_008756417
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768835   ⟹   XP_008767057
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,958 (-)NCBI
Rnor_6.01183,907,659 - 83,927,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598182   ⟹   XP_017453671
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,958 (-)NCBI
Rnor_6.01183,907,659 - 83,927,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598183   ⟹   XP_017453672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,500 (-)NCBI
Rnor_6.01183,907,659 - 83,927,235 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598184   ⟹   XP_017453673
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,221,919 - 80,241,958 (-)NCBI
Rnor_6.01183,907,659 - 83,927,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017604365   ⟹   XP_017459854
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1179,061,657 - 79,081,209 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_006221256   ⟸   XM_006221194
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006221257   ⟸   XM_006221195
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006248646   ⟸   XM_006248584
- Peptide Label: isoform X4
- UniProtKB: D4AD15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248647   ⟸   XM_006248585
- Peptide Label: isoform X4
- UniProtKB: D4AD15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248645   ⟸   XM_006248583
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006248643   ⟸   XM_006248581
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008756417   ⟸   XM_008758195
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_008756406   ⟸   XM_008758184
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008756408   ⟸   XM_008758186
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008756410   ⟸   XM_008758188
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_008756403   ⟸   XM_008758181
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008767057   ⟸   XM_008768835
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017459854   ⟸   XM_017604365
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017453673   ⟸   XM_017598184
- Peptide Label: isoform X2
- UniProtKB: D3ZU13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453671   ⟸   XM_017598182
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453672   ⟸   XM_017598183
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000049629   ⟸   ENSRNOT00000041777
RefSeq Acc Id: ENSRNOP00000040698   ⟸   ENSRNOT00000040029
RefSeq Acc Id: ENSRNOP00000067492   ⟸   ENSRNOT00000075306
Protein Domains
MI   W2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698271
Promoter ID:EPDNEW_R8796
Type:single initiation site
Name:Eif4g1_1
Description:eukaryotic translation initiation factor 4 gamma, 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,926,505 - 83,926,565EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306144 AgrOrtholog
Ensembl Genes ENSRNOG00000001738 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000049598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040698 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000049629 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000067492 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040029 UniProtKB/TrEMBL
  ENSRNOT00000041777 UniProtKB/TrEMBL
  ENSRNOT00000075306 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.180 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380777 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/TrEMBL
  EIF4G1 UniProtKB/TrEMBL
  eIF5C UniProtKB/TrEMBL
  Initiation_fac_eIF4g_MI UniProtKB/TrEMBL
  MIF4-like_sf UniProtKB/TrEMBL
  MIF4G-like_typ-3 UniProtKB/TrEMBL
KEGG Report rno:287986 UniProtKB/TrEMBL
MGC_CLONE MGC:112933 IMAGE-MGC_LOAD
NCBI Gene 287986 ENTREZGENE
PANTHER PTHR23253:SF10 UniProtKB/TrEMBL
Pfam MA3 UniProtKB/TrEMBL
  MIF4G UniProtKB/TrEMBL
  PF02020 UniProtKB/TrEMBL
PhenoGen Eif4g1 PhenoGen
PROSITE PS51363 UniProtKB/TrEMBL
  PS51366 UniProtKB/TrEMBL
SMART eIF5C UniProtKB/TrEMBL
  MA3 UniProtKB/TrEMBL
  MIF4G UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt D3ZU13 ENTREZGENE, UniProtKB/TrEMBL
  D4AD15 ENTREZGENE, UniProtKB/TrEMBL
  M0RD03_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Eif4g1  eukaryotic translation initiation factor 4 gamma, 1  LOC100912571  eukaryotic translation initiation factor 4 gamma 1-like  Data Merged 737654 PROVISIONAL
2015-07-29 Eif4g1  eukaryotic translation initiation factor 4 gamma, 1  LOC102550847  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like  Data Merged 737654 PROVISIONAL
2013-12-18 LOC102550847  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100912571  eukaryotic translation initiation factor 4 gamma 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Eif4g1  eukaryotic translation initiation factor 4 gamma, 1  Eif4g1_predicted  eukaryotic translation initiation factor 4 gamma, 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Eif4g1_predicted  eukaryotic translation initiation factor 4 gamma, 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED