Ntsr1 (neurotensin receptor 1) - Rat Genome Database

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Gene: Ntsr1 (neurotensin receptor 1) Rattus norvegicus
Analyze
Symbol: Ntsr1
Name: neurotensin receptor 1
RGD ID: 1306076
Description: Enables identical protein binding activity. Involved in several processes, including amino acid import across plasma membrane; positive regulation of organic acid transport; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including dendrite; perikaryon; and symmetric synapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human NTSR1 (neurotensin receptor 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: high-affinity levocabastine-insensitive neurotensin receptor; LOC366274; neurotensin receptor; neurotensin receptor type 1; NT-R-1; NTR1; NTRH; Ntsr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,983,778 - 188,033,934 (+)NCBIGRCr8
mRatBN7.23167,606,215 - 167,656,371 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,606,215 - 167,656,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,986,455 - 172,036,627 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,945,543 - 180,995,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,607,136 - 177,657,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,982,313 - 176,046,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,885,894 - 176,046,345 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03179,681,394 - 179,747,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,567,488 - 169,633,121 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,473,987 - 169,536,964 (+)NCBI
Celera3164,925,618 - 164,973,840 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Widespread expression in adult rat forebrain of mRNA encoding high-affinity neurotensin receptor. Alexander MJ and Leeman SE, J Comp Neurol. 1998 Dec 28;402(4):475-500.
2. Neurotensin receptor involvement in the rise of extracellular glutamate levels and apoptotic nerve cell death in primary cortical cultures after oxygen and glucose deprivation. Antonelli T, etal., Cereb Cortex. 2008 Aug;18(8):1748-57. Epub 2007 Dec 5.
3. Constitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix seven. Barroso S, etal., Br J Pharmacol. 2002 Feb;135(4):997-1002.
4. Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. Boudin H, etal., J Comp Neurol. 1996 Sep 9;373(1):76-89.
5. Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra. Boudin H, etal., J Neurosci. 1998 Oct 15;18(20):8473-84.
6. Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive. Buhler AV, etal., Pain. 2005 Mar;114(1-2):285-94. Epub 2005 Jan 26.
7. Neurotensin depolarizes globus pallidus neurons in rats via neurotensin type-1 receptor. Chen L, etal., Neuroscience. 2004;125(4):853-9.
8. Effects of neurotensin on discharge rates of rat suprachiasmatic nucleus neurons in vitro. Coogan AN, etal., Neuroscience. 2001;103(3):663-72.
9. Developmental expression of the neurotensin gene in the rat liver. Evers BM, etal., Ann Surg. 1993 Aug;218(2):183-8.
10. Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Fassio A, etal., Neuropharmacology. 2000 Jun 8;39(8):1430-42.
11. Striatal NTS1 , dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release--a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat. Ferraro L, etal., Eur J Neurosci. 2012 Jan;35(2):207-20. doi: 10.1111/j.1460-9568.2011.07949.x. Epub 2011 Dec 30.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. Guillemette A, etal., Eur J Pain. 2012 Apr;16(4):473-84. doi: 10.1016/j.ejpain.2011.07.008.
15. Direct analysis of a GPCR-agonist interaction by surface plasmon resonance. Harding PJ, etal., Eur Biophys J. 2006 Oct;35(8):709-12. Epub 2006 May 18.
16. Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid. Inagaki S, etal., J Mol Biol. 2012 Mar 16;417(1-2):95-111. doi: 10.1016/j.jmb.2012.01.023. Epub 2012 Jan 27.
17. Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Johnson MD, etal., Hypertension. 2009 Sep;54(3):639-45. Epub 2009 Jul 20.
18. Characterization of neurotensin receptors. Kitabgi P and Pelaprat D, Curr Protoc Pharmacol. 2004 May;Chapter 1:Unit 1.29. doi: 10.1002/0471141755.ph0129s24.
19. The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala. Laszlo K, etal., Behav Brain Res. 2012 Jan 15;226(2):597-600. doi: 10.1016/j.bbr.2011.08.041. Epub 2011 Sep 21.
20. An Association Study of Neurotensin Receptor Gene's Polymorphism with Schizophrenia Lee YS, Kim HB, Han JH, Chai YG, Lee JS, Lee HS, Joo YH, Kim HS, Choi IG, Yang BH, J Korean Neuropsychiatr Assoc 1999 Nov;38(6):1494-1501.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey. Mitchell VA, etal., J Physiol. 2009 Jun 1;587(Pt 11):2511-20. doi: 10.1113/jphysiol.2008.167429. Epub 2009 Apr 9.
23. Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins. Najimi M, etal., FEBS Lett. 2002 Feb 13;512(1-3):329-33.
24. Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. Najimi M, etal., FEBS Lett. 2002 Jul 17;523(1-3):224-8.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Neurotensin modulates synaptic transmission in the nucleus of the solitary tract of the rat. Ogawa WN, etal., Neuroscience. 2005;130(2):309-15.
27. High-affinity neurotensin receptor is involved in phosphoinositide hydrolysis stimulation by carbachol in neonatal rat brain. Pereyra-Alfonso S, etal., Brain Res Dev Brain Res. 2005 Feb 8;154(2):247-54. Epub 2005 Jan 11.
28. NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization. Perron A, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):582-90. Epub 2006 Dec 18.
29. Neurotensin activates GABAergic interneurons in the prefrontal cortex. Petrie KA, etal., J Neurosci. 2005 Feb 16;25(7):1629-36.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model. Roussy G, etal., J Neurochem. 2008 May;105(4):1100-14. doi: 10.1111/j.1471-4159.2007.05205.x. Epub 2007 Dec 25.
35. Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells. Sarret P, etal., J Biol Chem 2002 Sep 27;277(39):36233-43.
36. Neurotensin regulates intracellular calcium in ventral tegmental area astrocytes: evidence for the involvement of multiple receptors. Trudeau LE Neuroscience. 2000;97(2):293-302.
37. Immunohistochemical evidence for the implication of PC1 in the processing of proneurotensin in rat brain. Villeneuve P, etal., Neuroreport. 2000 Nov 9;11(16):3443-7.
38. Heterogeneity of melanized neurons expressing neurotensin receptor messenger RNA in the substantia nigra and the nucleus paranigralis of control and Parkinson's disease brain. Yamada M, etal., Neuroscience. 1995 Jan;64(2):405-17.
39. Regulation of daily rhythm of body temperature by neurotensin receptor in rats. Yamada M, etal., Res Commun Mol Pathol Pharmacol. 1995 Mar;87(3):323-32.
Additional References at PubMed
PMID:1694443   PMID:8381365   PMID:8839352   PMID:15353215   PMID:16953387   PMID:17620610   PMID:17664042   PMID:18835308   PMID:20403392   PMID:21725197   PMID:23051748   PMID:24831231  
PMID:24978951   PMID:25157640   PMID:25807267   PMID:26783230   PMID:26926422   PMID:27523794   PMID:27586561   PMID:28089664   PMID:29596791   PMID:32561375   PMID:34508168  


Genomics

Comparative Map Data
Ntsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,983,778 - 188,033,934 (+)NCBIGRCr8
mRatBN7.23167,606,215 - 167,656,371 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,606,215 - 167,656,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,986,455 - 172,036,627 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,945,543 - 180,995,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,607,136 - 177,657,300 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,982,313 - 176,046,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,885,894 - 176,046,345 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03179,681,394 - 179,747,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,567,488 - 169,633,121 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,473,987 - 169,536,964 (+)NCBI
Celera3164,925,618 - 164,973,840 (-)NCBICelera
Cytogenetic Map3q43NCBI
NTSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382062,708,836 - 62,762,771 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2062,708,836 - 62,762,771 (+)EnsemblGRCh38hg38GRCh38
GRCh372061,340,188 - 61,394,123 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362060,810,634 - 60,864,568 (+)NCBINCBI36Build 36hg18NCBI36
Build 342060,810,633 - 60,864,567NCBI
Celera2058,015,902 - 58,069,780 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,057,195 - 58,112,133 (+)NCBIHuRef
CHM1_12061,240,216 - 61,294,517 (+)NCBICHM1_1
T2T-CHM13v2.02064,507,559 - 64,561,762 (+)NCBIT2T-CHM13v2.0
Ntsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,141,769 - 180,186,772 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,141,769 - 180,186,773 (+)EnsemblGRCm39 Ensembl
GRCm382180,499,976 - 180,544,979 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,499,976 - 180,544,980 (+)EnsemblGRCm38mm10GRCm38
MGSCv372180,234,681 - 180,279,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,429,384 - 180,474,387 (+)NCBIMGSCv36mm8
Celera2184,584,976 - 184,630,855 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.04NCBI
Ntsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555281,348,555 - 1,394,868 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555281,348,616 - 1,394,798 (-)NCBIChiLan1.0ChiLan1.0
NTSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,500,208 - 68,551,762 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12068,493,332 - 68,544,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02059,100,110 - 59,151,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12060,392,736 - 60,446,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2060,392,736 - 60,446,056 (+)Ensemblpanpan1.1panPan2
NTSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,576,690 - 46,615,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2446,576,501 - 46,615,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2445,761,069 - 45,799,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02447,445,631 - 47,483,515 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2447,445,292 - 47,483,519 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12446,546,845 - 46,585,056 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02446,670,214 - 46,708,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,425,128 - 47,463,367 (+)NCBIUU_Cfam_GSD_1.0
Ntsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640194,786,843 - 194,821,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,241,020 - 10,272,816 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,240,990 - 10,272,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,989,402 - 62,033,548 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11761,989,601 - 62,038,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NTSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121,466,965 - 1,521,681 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21,469,378 - 1,521,323 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605049,354,595 - 49,410,303 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntsr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474128,505,037 - 28,544,122 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474128,504,814 - 28,543,592 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ntsr1
334 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:571
Count of miRNA genes:235
Interacting mature miRNAs:296
Transcripts:ENSRNOT00000039780
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12
Low 3 1 4 2 1 2 50 4 12
Below cutoff 36 27 18 6 18 7 10 12 9 28 6 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039780   ⟹   ENSRNOP00000035997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,606,215 - 167,656,377 (+)Ensembl
Rnor_6.0 Ensembl3175,885,894 - 176,046,345 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082073   ⟹   ENSRNOP00000072865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3175,982,777 - 176,044,152 (+)Ensembl
RefSeq Acc Id: NM_001108967   ⟹   NP_001102437
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,983,778 - 188,033,934 (+)NCBI
mRatBN7.23167,606,215 - 167,656,371 (+)NCBI
Rnor_6.03175,982,313 - 176,046,345 (+)NCBI
Rnor_5.03179,681,394 - 179,747,034 (+)NCBI
RGSC_v3.43169,567,488 - 169,633,121 (+)RGD
Celera3164,925,618 - 164,973,840 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102437 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88805 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035997
  ENSRNOP00000035997.2
  ENSRNOP00055001411
  ENSRNOP00060001124
  ENSRNOP00065018686
GenBank Protein P20789 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001102437   ⟸   NM_001108967
- UniProtKB: P20789 (UniProtKB/Swiss-Prot),   A6KM97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072865   ⟸   ENSRNOT00000082073
RefSeq Acc Id: ENSRNOP00000035997   ⟸   ENSRNOT00000039780
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20789-F1-model_v2 AlphaFold P20789 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306076 AgrOrtholog
BioCyc Gene G2FUF-46329 BioCyc
Ensembl Genes ENSRNOG00000028708 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055001097 UniProtKB/Swiss-Prot
  ENSRNOG00060001326 UniProtKB/Swiss-Prot
  ENSRNOG00065014521 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039780 ENTREZGENE
  ENSRNOT00000039780.4 UniProtKB/Swiss-Prot
  ENSRNOT00055001811 UniProtKB/Swiss-Prot
  ENSRNOT00060001917 UniProtKB/Swiss-Prot
  ENSRNOT00065023983 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NT1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NT_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:366274 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 366274 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROTENSIN RECEPTOR TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ntsr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROTENSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROTENSN1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028708 RatGTEx
  ENSRNOG00055001097 RatGTEx
  ENSRNOG00060001326 RatGTEx
  ENSRNOG00065014521 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KM97 ENTREZGENE, UniProtKB/TrEMBL
  NTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ntsr1  neurotensin receptor 1   Ntsr1_predicted  neurotensin receptor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2007-04-24 Ntsr1_predicted  neurotensin receptor 1 (predicted)  Ntsr1  neurotensin receptor 1  Data merged from RGD:619865 737654 APPROVED
2006-03-21 Ntsr1_predicted  neurotensin receptor 1 (predicted)  Ntsr_predicted  neurotensin receptor (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 Ntsr1  neurotensin receptor 1  Ntsr  neurotensin receptor  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ntsr_predicted  neurotensin receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Ntsr  neurotensin receptor      Symbol and Name status set to provisional 70820 PROVISIONAL