Aifm2 (apoptosis inducing factor, mitochondria associated 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Aifm2 (apoptosis inducing factor, mitochondria associated 2) Rattus norvegicus
Analyze
Symbol: Aifm2
Name: apoptosis inducing factor, mitochondria associated 2
RGD ID: 1304964
Description: Predicted to enable several functions, including electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Predicted to be involved in several processes, including negative regulation of ferroptosis; regulation of cellular response to oxidative stress; and vitamin K metabolic process. Predicted to be located in several cellular components, including cytosol; lipid droplet; and mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human AIFM2 (apoptosis inducing factor mitochondria associated 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amid; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; apoptosis-inducing factor, mitochondrion-associated 2; ferroptosis suppressor protein 1; LOC361843; Prg3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,195,781 - 30,222,014 (+)NCBIGRCr8
mRatBN7.22029,654,283 - 29,679,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,652,927 - 29,679,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,676,029 - 30,689,153 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02030,067,240 - 30,080,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,809,721 - 30,822,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,329,047 - 31,353,548 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,339,787 - 31,352,906 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02033,126,313 - 33,153,173 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,089,730 - 29,104,084 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12029,092,816 - 29,117,878 (+)NCBI
Celera2031,091,780 - 31,104,758 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldrin  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP,ISO)
fulvestrant  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
ibuprofen  (EXP,ISO)
inulin  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
nickel dichloride  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:11980907   PMID:12135761   PMID:12947022   PMID:14741744   PMID:15958387   PMID:16186796   PMID:18614015   PMID:22664934   PMID:26689472   PMID:31634899   PMID:31634900  


Genomics

Comparative Map Data
Aifm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,195,781 - 30,222,014 (+)NCBIGRCr8
mRatBN7.22029,654,283 - 29,679,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,652,927 - 29,679,236 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,676,029 - 30,689,153 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02030,067,240 - 30,080,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,809,721 - 30,822,853 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,329,047 - 31,353,548 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,339,787 - 31,352,906 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02033,126,313 - 33,153,173 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,089,730 - 29,104,084 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12029,092,816 - 29,117,878 (+)NCBI
Celera2031,091,780 - 31,104,758 (+)NCBICelera
Cytogenetic Map20q11NCBI
AIFM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,112,271 - 70,132,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,098,223 - 70,132,934 (-)EnsemblGRCh38hg38GRCh38
GRCh371071,872,027 - 71,892,581 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,542,036 - 71,562,696 (-)NCBINCBI36Build 36hg18NCBI36
Celera1065,151,142 - 65,171,802 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1065,864,657 - 65,885,178 (-)NCBIHuRef
CHM1_11072,154,045 - 72,174,696 (-)NCBICHM1_1
T2T-CHM13v2.01070,981,272 - 71,001,807 (-)NCBIT2T-CHM13v2.0
Aifm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,551,042 - 61,575,474 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,551,042 - 61,575,039 (+)EnsemblGRCm39 Ensembl
GRCm381061,715,263 - 61,739,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,715,263 - 61,739,260 (+)EnsemblGRCm38mm10GRCm38
MGSCv371061,178,011 - 61,202,008 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361061,110,645 - 61,134,617 (+)NCBIMGSCv36mm8
Celera1062,816,777 - 62,840,752 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.27NCBI
Aifm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543721,110,798 - 21,126,482 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543721,111,298 - 21,126,487 (+)NCBIChiLan1.0ChiLan1.0
AIFM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,209,189 - 82,286,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,213,225 - 82,308,666 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01066,529,411 - 66,621,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,114,188 - 69,135,265 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,114,194 - 69,135,267 (-)Ensemblpanpan1.1panPan2
AIFM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,086,778 - 21,104,127 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,087,339 - 21,104,172 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,219,576 - 21,236,813 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,362,486 - 21,379,970 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1421,260,186 - 21,277,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,465,343 - 21,482,591 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,816,121 - 21,833,576 (-)NCBIUU_Cfam_GSD_1.0
Aifm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,973,364 - 59,981,473 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,466,086 - 8,474,198 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,466,089 - 8,474,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIFM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,055,228 - 73,074,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,054,433 - 73,074,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21478,974,255 - 78,993,913 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AIFM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1961,174,125 - 61,197,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl961,182,826 - 61,195,769 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,913,157 - 21,936,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aifm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,276,928 - 4,301,365 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,276,579 - 4,301,058 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aifm2
224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:603
Count of miRNA genes:294
Interacting mature miRNAs:377
Transcripts:ENSRNOT00000035982
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
RH127435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22029,677,689 - 29,677,906 (+)MAPPERmRatBN7.2
Rnor_6.02031,352,420 - 31,352,636NCBIRnor6.0
Rnor_5.02033,152,045 - 33,152,261UniSTSRnor5.0
RGSC_v3.42029,103,592 - 29,103,808UniSTSRGSC3.4
Celera2031,104,266 - 31,104,482UniSTS
Cytogenetic Map20q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 33 21 4 21 2 2 17 25 35 11 2
Low 3 31 24 20 15 20 6 9 57 10 6 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001139483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA818254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC139981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW521424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF391566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF114906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000082463   ⟹   ENSRNOP00000071310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,665,045 - 29,678,179 (+)Ensembl
Rnor_6.0 Ensembl2031,339,787 - 31,352,906 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110362   ⟹   ENSRNOP00000080268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,654,278 - 29,679,236 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115140   ⟹   ENSRNOP00000096918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,652,927 - 29,678,100 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118141   ⟹   ENSRNOP00000076399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,654,382 - 29,677,767 (+)Ensembl
RefSeq Acc Id: NM_001139483   ⟹   NP_001132955
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,207,829 - 30,220,963 (+)NCBI
mRatBN7.22029,665,045 - 29,678,182 (+)NCBI
Rnor_6.02031,339,787 - 31,352,912 (+)NCBI
Rnor_5.02033,126,313 - 33,153,173 (+)NCBI
RGSC_v3.42029,089,730 - 29,104,084 (+)RGD
Celera2031,091,780 - 31,104,758 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256453   ⟹   XP_006256515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,088 - 30,222,014 (+)NCBI
mRatBN7.22029,654,284 - 29,678,182 (+)NCBI
Rnor_6.02031,329,047 - 31,352,912 (+)NCBI
Rnor_5.02033,126,313 - 33,153,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256454   ⟹   XP_006256516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,122 - 30,222,014 (+)NCBI
mRatBN7.22029,654,343 - 29,678,182 (+)NCBI
Rnor_6.02031,329,069 - 31,350,831 (+)NCBI
Rnor_5.02033,126,313 - 33,153,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256456   ⟹   XP_006256518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,087 - 30,222,014 (+)NCBI
mRatBN7.22029,654,291 - 29,678,182 (+)NCBI
Rnor_6.02031,329,050 - 31,350,831 (+)NCBI
Rnor_5.02033,126,313 - 33,153,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772888   ⟹   XP_008771110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,088 - 30,222,014 (+)NCBI
mRatBN7.22029,654,284 - 29,678,182 (+)NCBI
Rnor_6.02031,329,047 - 31,350,831 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601691   ⟹   XP_017457180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,088 - 30,222,014 (+)NCBI
mRatBN7.22029,654,283 - 29,678,182 (+)NCBI
Rnor_6.02031,329,047 - 31,350,831 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098871   ⟹   XP_038954799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,125 - 30,222,014 (+)NCBI
mRatBN7.22029,654,347 - 29,678,182 (+)NCBI
RefSeq Acc Id: XM_039098873   ⟹   XP_038954801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,290 - 30,222,014 (+)NCBI
mRatBN7.22029,654,513 - 29,678,182 (+)NCBI
RefSeq Acc Id: XM_063279294   ⟹   XP_063135364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,195,781 - 30,222,014 (+)NCBI
RefSeq Acc Id: XM_063279295   ⟹   XP_063135365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,290 - 30,222,014 (+)NCBI
RefSeq Acc Id: XM_063279296   ⟹   XP_063135366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,087 - 30,222,014 (+)NCBI
RefSeq Acc Id: XM_063279297   ⟹   XP_063135367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,088 - 30,222,014 (+)NCBI
RefSeq Acc Id: XM_063279299   ⟹   XP_063135369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,122 - 30,222,014 (+)NCBI
RefSeq Acc Id: XM_063279300   ⟹   XP_063135370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,088 - 30,213,753 (+)NCBI
RefSeq Acc Id: XM_063279301   ⟹   XP_063135371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,121 - 30,213,753 (+)NCBI
RefSeq Acc Id: XR_005497285
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,197,088 - 30,222,014 (+)NCBI
mRatBN7.22029,654,284 - 29,679,239 (+)NCBI
RefSeq Acc Id: NP_001132955   ⟸   NM_001139483
- UniProtKB: D4AA14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256515   ⟸   XM_006256453
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQB7 (UniProtKB/TrEMBL),   D4AA14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256516   ⟸   XM_006256454
- Peptide Label: isoform X3
- UniProtKB: D4AA14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256518   ⟸   XM_006256456
- Peptide Label: isoform X5
- UniProtKB: D4AA14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771110   ⟸   XM_008772888
- Peptide Label: isoform X1
- UniProtKB: D4AA14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457180   ⟸   XM_017601691
- Peptide Label: isoform X7
- UniProtKB: A0A8I5XUU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071310   ⟸   ENSRNOT00000082463
RefSeq Acc Id: XP_038954799   ⟸   XM_039098871
- Peptide Label: isoform X4
- UniProtKB: D4AA14 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954801   ⟸   XM_039098873
- Peptide Label: isoform X5
- UniProtKB: D4AA14 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000076399   ⟸   ENSRNOT00000118141
RefSeq Acc Id: ENSRNOP00000096918   ⟸   ENSRNOT00000115140
RefSeq Acc Id: ENSRNOP00000080268   ⟸   ENSRNOT00000110362
RefSeq Acc Id: XP_063135364   ⟸   XM_063279294
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063135366   ⟸   XM_063279296
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063135367   ⟸   XM_063279297
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063135370   ⟸   XM_063279300
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063135371   ⟸   XM_063279301
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063135369   ⟸   XM_063279299
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063135365   ⟸   XM_063279295
- Peptide Label: isoform X6
Protein Domains
FAD/NAD(P)-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA14-F1-model_v2 AlphaFold D4AA14 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304964 AgrOrtholog
BioCyc Gene G2FUF-3714 BioCyc
Ensembl Genes ENSRNOG00000059445 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082463 ENTREZGENE
  ENSRNOT00000082463.2 UniProtKB/TrEMBL
  ENSRNOT00000110362.1 UniProtKB/TrEMBL
  ENSRNOT00000115140.1 UniProtKB/TrEMBL
  ENSRNOT00000118141.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.100 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_FAD/NAD UniProtKB/TrEMBL
NCBI Gene 361843 ENTREZGENE
PANTHER APOPTOSIS-INDUCING FACTOR 1 UniProtKB/TrEMBL
  FERROPTOSIS SUPPRESSOR PROTEIN 1 UniProtKB/TrEMBL
Pfam Pyr_redox_2 UniProtKB/TrEMBL
PhenoGen Aifm2 PhenoGen
PRINTS FADPNR UniProtKB/TrEMBL
  PNDRDTASEII UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059445 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt A0A8I5XUU7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMA9_RAT UniProtKB/TrEMBL
  D4AA14 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Aifm2  apoptosis inducing factor, mitochondria associated 2  Aifm2  apoptosis-inducing factor, mitochondrion-associated 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Aifm2  apoptosis-inducing factor, mitochondrion-associated 2  Amid_predicted  apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Amid_predicted  apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death (predicted)      Symbol and Name status set to approved 70820 APPROVED