Bcap31 (B-cell receptor-associated protein 31) - Rat Genome Database

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Gene: Bcap31 (B-cell receptor-associated protein 31) Rattus norvegicus
Analyze
Symbol: Bcap31
Name: B-cell receptor-associated protein 31
RGD ID: 1302944
Description: Predicted to enable MHC class I protein binding activity. Predicted to be involved in several processes, including intracellular calcium ion homeostasis; positive regulation of proteolysis involved in protein catabolic process; and protein localization to organelle. Predicted to act upstream of or within immune response. Located in Golgi cisterna membrane; clathrin-coated vesicle; and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to human BCAP31 (B cell receptor associated protein 31); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bap31; MGC94221; similar to B-cell receptor-associated protein 31
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,548,911 - 156,581,002 (-)NCBIGRCr8
mRatBN7.2X151,397,567 - 151,429,666 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,397,576 - 151,428,506 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,538,741 - 153,569,200 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,101,972 - 157,132,430 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,773,802 - 154,804,259 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X157,094,365 - 157,126,397 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,095,937 - 157,126,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,843,762 - 152,875,715 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,583,683 - 159,614,143 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,658,111 - 159,688,572 (-)NCBI
Celera1136,461,516 - 136,491,976 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. Annaert WG, etal., J Cell Biol. 1997 Dec 15;139(6):1397-410.
2. Proteomics characterization of abundant Golgi membrane proteins. Bell AW, etal., J Biol Chem 2001 Feb 16;276(7):5152-65. Epub 2000 Oct 19.
3. Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus. Cacciagli P, etal., Am J Hum Genet. 2013 Sep 5;93(3):579-86. doi: 10.1016/j.ajhg.2013.07.023.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Bap29/31 influences the intracellular traffic of MHC class I molecules. Paquet ME, etal., J Immunol 2004 Jun 15;172(12):7548-55.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8612576   PMID:8706661   PMID:14581517   PMID:14741744   PMID:18555783   PMID:19401338   PMID:19857118   PMID:19946888   PMID:21183955   PMID:22871113   PMID:24454821   PMID:25854864  


Genomics

Comparative Map Data
Bcap31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,548,911 - 156,581,002 (-)NCBIGRCr8
mRatBN7.2X151,397,567 - 151,429,666 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,397,576 - 151,428,506 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,538,741 - 153,569,200 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,101,972 - 157,132,430 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,773,802 - 154,804,259 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X157,094,365 - 157,126,397 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,095,937 - 157,126,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,843,762 - 152,875,715 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,583,683 - 159,614,143 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,658,111 - 159,688,572 (-)NCBI
Celera1136,461,516 - 136,491,976 (+)NCBICelera
Cytogenetic MapXq37NCBI
BCAP31
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,700,492 - 153,724,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,700,492 - 153,724,565 (-)EnsemblGRCh38hg38GRCh38
GRCh37X152,965,947 - 152,989,842 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,619,146 - 152,643,081 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,486,798 - 152,510,734NCBI
CeleraX153,199,631 - 153,223,882 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,623,032 - 141,647,457 (-)NCBIHuRef
CHM1_1X152,840,359 - 152,864,610 (-)NCBICHM1_1
T2T-CHM13v2.0X151,974,158 - 151,998,050 (-)NCBIT2T-CHM13v2.0
Bcap31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,729,784 - 72,761,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,729,784 - 72,759,781 (-)EnsemblGRCm39 Ensembl
GRCm38X73,686,178 - 73,717,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,686,178 - 73,716,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X70,931,522 - 70,961,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,938,903 - 69,968,895 (-)NCBIMGSCv36mm8
CeleraX64,939,998 - 64,969,873 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.38NCBI
Bcap31
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580428,644 - 459,168 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580429,223 - 459,168 (-)NCBIChiLan1.0ChiLan1.0
LOC100976022
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21235,003,213 - 35,006,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A35,005,973 - 35,009,550 (+)NCBINHGRI_mPanPan1
PanPan1.1X153,137,992 - 153,161,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,137,992 - 153,161,628 (-)Ensemblpanpan1.1panPan2
BCAP31
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,515,417 - 121,550,373 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,507,084 - 121,545,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,844,790 - 106,879,849 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,656,935 - 124,692,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,656,941 - 124,686,801 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,426,370 - 120,461,432 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X122,941,327 - 122,976,452 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,703,489 - 122,738,554 (-)NCBIUU_Cfam_GSD_1.0
Bcap31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X118,844,918 - 118,877,048 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809582,649 - 615,079 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809582,689 - 614,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAP31
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,457,001 - 124,484,743 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,456,999 - 124,484,923 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,021,546 - 142,049,432 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCAP31
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,128,739 - 128,152,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,128,271 - 128,151,823 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606565,991,062 - 66,018,684 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcap31
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946399,227 - 419,642 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946398,901 - 420,767 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcap31
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000025813
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH128478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,397,699 - 151,397,909 (-)MAPPERmRatBN7.2
Rnor_6.0X157,126,057 - 157,126,266NCBIRnor6.0
Rnor_5.01152,875,375 - 152,875,584UniSTSRnor5.0
RGSC_v3.4X159,583,814 - 159,584,023UniSTSRGSC3.4
Celera1136,491,636 - 136,491,845UniSTS
Cytogenetic MapXq37UniSTS
BE117505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,398,431 - 151,398,643 (-)MAPPERmRatBN7.2
Rnor_6.0X157,125,323 - 157,125,534NCBIRnor6.0
Rnor_5.01152,874,641 - 152,874,852UniSTSRnor5.0
RGSC_v3.4X159,584,546 - 159,584,757UniSTSRGSC3.4
Celera1136,490,902 - 136,491,113UniSTS
Cytogenetic MapXq37UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000091792   ⟹   ENSRNOP00000070305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,397,577 - 151,427,745 (-)Ensembl
Rnor_6.0 EnsemblX157,095,937 - 157,126,393 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099703   ⟹   ENSRNOP00000082446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,397,576 - 151,428,047 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100090   ⟹   ENSRNOP00000082335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,397,577 - 151,428,506 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107086   ⟹   ENSRNOP00000083599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,397,579 - 151,427,993 (-)Ensembl
RefSeq Acc Id: NM_001004224   ⟹   NP_001004224
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,548,911 - 156,579,371 (-)NCBI
mRatBN7.2X151,397,569 - 151,428,035 (-)NCBI
Rnor_6.0X157,095,937 - 157,126,397 (+)NCBI
Rnor_5.01152,843,762 - 152,875,715 (+)NCBI
RGSC_v3.4X159,583,683 - 159,614,143 (-)RGD
Celera1136,461,516 - 136,491,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229556   ⟹   XP_006229618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,548,916 - 156,581,002 (-)NCBI
mRatBN7.2X151,397,569 - 151,429,666 (-)NCBI
Rnor_6.0X157,094,365 - 157,126,397 (+)NCBI
Rnor_5.01152,843,762 - 152,875,715 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229557   ⟹   XP_006229619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,548,916 - 156,579,649 (-)NCBI
mRatBN7.2X151,397,567 - 151,428,306 (-)NCBI
Rnor_6.0X157,095,679 - 157,126,397 (+)NCBI
Rnor_5.01152,843,762 - 152,875,715 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099529   ⟹   XP_038955457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,548,916 - 156,579,330 (-)NCBI
mRatBN7.2X151,397,567 - 151,427,994 (-)NCBI
RefSeq Acc Id: XM_063279836   ⟹   XP_063135906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,548,916 - 156,579,437 (-)NCBI
RefSeq Acc Id: NP_001004224   ⟸   NM_001004224
- UniProtKB: Q6AY58 (UniProtKB/TrEMBL),   A0A8I5ZTY8 (UniProtKB/TrEMBL),   A0A0G2JXK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229618   ⟸   XM_006229556
- Peptide Label: isoform X2
- UniProtKB: Q6AY58 (UniProtKB/TrEMBL),   A0A8I5ZTY8 (UniProtKB/TrEMBL),   A0A0G2JXK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229619   ⟸   XM_006229557
- Peptide Label: isoform X2
- UniProtKB: Q6AY58 (UniProtKB/TrEMBL),   A0A8I5ZTY8 (UniProtKB/TrEMBL),   A0A0G2JXK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070305   ⟸   ENSRNOT00000091792
RefSeq Acc Id: XP_038955457   ⟸   XM_039099529
- Peptide Label: isoform X2
- UniProtKB: Q6AY58 (UniProtKB/TrEMBL),   A0A8I5ZTY8 (UniProtKB/TrEMBL),   A0A0G2JXK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083599   ⟸   ENSRNOT00000107086
RefSeq Acc Id: ENSRNOP00000082335   ⟸   ENSRNOT00000100090
RefSeq Acc Id: ENSRNOP00000082446   ⟸   ENSRNOT00000099703
RefSeq Acc Id: XP_063135906   ⟸   XM_063279836
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY58-F1-model_v2 AlphaFold Q6AY58 1-245 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702056
Promoter ID:EPDNEW_R12580
Type:initiation region
Name:Bcap31_1
Description:B-cell receptor-associated protein 31
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X157,095,946 - 157,096,006EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302944 AgrOrtholog
BioCyc Gene G2FUF-667 BioCyc
Ensembl Genes ENSRNOG00000055756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091792 ENTREZGENE
  ENSRNOT00000091792.2 UniProtKB/TrEMBL
  ENSRNOT00000099703.1 UniProtKB/TrEMBL
  ENSRNOT00000100090.1 UniProtKB/TrEMBL
  ENSRNOT00000107086.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130880 IMAGE-MGC_LOAD
InterPro BAP29/BAP31_N UniProtKB/TrEMBL
  Bap31 UniProtKB/TrEMBL
  Bap31/Bap29_C UniProtKB/TrEMBL
KEGG Report rno:293852 UniProtKB/TrEMBL
MGC_CLONE MGC:94221 IMAGE-MGC_LOAD
NCBI Gene 293852 ENTREZGENE
PANTHER B-CELL RECEPTOR-ASSOCIATED PROTEIN 31 UniProtKB/TrEMBL
  Bap31 UniProtKB/TrEMBL
Pfam Bap31 UniProtKB/TrEMBL
  Bap31_Bap29_C UniProtKB/TrEMBL
PhenoGen Bcap31 PhenoGen
RatGTEx ENSRNOG00000055756 RatGTEx
UniProt A0A0G2JXK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTY8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWB7_RAT UniProtKB/TrEMBL
  A0A8I5ZX74_RAT UniProtKB/TrEMBL
  A6KRW2_RAT UniProtKB/TrEMBL
  A6KRW6_RAT UniProtKB/TrEMBL
  A6KRW9_RAT UniProtKB/TrEMBL
  Q6AY58 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Bcap31  B-cell receptor-associated protein 31  MGC94221  similar to B-cell receptor-associated protein 31  Symbol and Name updated 1299863 APPROVED
2005-02-14 MGC94221  similar to B-cell receptor-associated protein 31      Symbol and Name status set to provisional 70820 PROVISIONAL