Sftpa1 (surfactant protein A1) - Rat Genome Database

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Gene: Sftpa1 (surfactant protein A1) Rattus norvegicus
Analyze
Symbol: Sftpa1
Name: surfactant protein A1
RGD ID: 3665
Description: Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space and multivesicular body. Biomarker of asthma; congenital diaphragmatic hernia; lung disease (multiple); and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to human SFTPA1 (surfactant protein A1) and SFTPA2 (surfactant protein A2); PARTICIPATES IN forkhead class A signaling pathway; phagocytosis pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100364823; LOC102557073; MGC105453; PSAP; PSP-A; pulmonary surfactant-associated protein A; pulmonary surfactant-associated protein A-like; Sftp1; Sftpa; Sftpl; SP-A; surfactant associated protein A; surfactant, pulmonary-associated protein A1; Surfactant-associated protein 1 (pulmonary surfactant protein SP-A); Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,042,264 - 17,045,770 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1617,042,255 - 17,045,769 (+)EnsemblGRCr8
mRatBN7.21617,008,180 - 17,011,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,008,180 - 17,011,685 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1617,072,970 - 17,076,475 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,199,439 - 18,202,946 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,125,874 - 17,129,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,716,019 - 18,719,404 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,716,019 - 18,719,403 (+)Ensemblrn6Rnor6.0
Rnor_5.01618,585,631 - 18,589,016 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41617,570,887 - 17,574,389 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1617,235,343 - 17,236,847 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse:


Gene Location:16:17042264..17045770

17.0425M17.0430M17.0435M17.0440M17.0445M17.0450M17.0455MNM_001270645 (Sftpa1)NM_001270647 (Sftpa1)NM_017329 (Sftpa1)XM_039094199 (Sftpa1)


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Object Symbol
Species
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Evidence
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Original Reference(s)
Sftpa1RatAcute Lung Injury  ISOSFTPA1 (Homo sapiens)4143451mRNA, protein:increased expression:pneumocyteRGD 
Sftpa1Ratadult respiratory distress syndrome  ISOSFTPA1 (Homo sapiens)4143436protein:increased expression:serumRGD 
Sftpa1Ratadult respiratory distress syndrome  ISOSFTPA1 (Homo sapiens)4143379protein:decreased expression:lungRGD 
Sftpa1Ratasthma  ISOSftpa1 (Mus musculus)4143289 RGD 
Sftpa1Ratasthma  ISOSFTPA1 (Homo sapiens)4143462protein:decreased expression:lungRGD 
Sftpa1Ratasthma  IEP 4143398protein:decreased expression:lung, Clara cell, pneumocyteRGD 
Sftpa1Ratasthma  IEP 4143516mRNA, protein:increased expression:lungRGD 
Sftpa1Ratbacterial pneumonia  IEP 4143464protein:increased expression:lungRGD 
Sftpa1RatBronchial Hyperreactivity  ISOSftpa1 (Mus musculus)4143407protein:decreased expression:lungRGD 
Sftpa1Ratbronchopulmonary dysplasia  ISOSFTPA1 (Homo sapiens)4143384DNA:snps, haplotypes:multiple (human)RGD 
Sftpa1Ratbronchopulmonary dysplasia susceptibilityISOSFTPA1 (Homo sapiens)4144876DNA:polymorphisms, haplotype: (human)RGD 
Sftpa1Ratchronic obstructive pulmonary disease susceptibilityISOSFTPA1 (Homo sapiens)4143423DNA:polymorphism:cds:c.186G>A (human)RGD 
Sftpa1Ratchronic obstructive pulmonary disease  ISOSFTPA1 (Homo sapiens)4143288protein:increased expression:lungRGD 
Sftpa1Ratchronic obstructive pulmonary disease  ISOSFTPA1 (Homo sapiens)4143281DNA:SNP:cds:p.L50V (human)RGD 
Sftpa1Ratcongenital diaphragmatic hernia treatmentIEP 151667435 RGD 
Sftpa1RatCough susceptibilityISOSFTPA1 (Homo sapiens)4144873DNA:SNPs, haplotypes:cds:multiple (human)RGD 
Sftpa1Ratcystic fibrosis  ISOSFTPA1 (Homo sapiens)4143403protein:decreased expression:lungRGD 
Sftpa1Ratextrinsic allergic alveolitis  ISOSFTPA1 (Homo sapiens)4143437protein:decreased expression:lungRGD 
Sftpa1RatFungal Lung Diseases susceptibilityISOSftpa1 (Mus musculus)4143489 RGD 
Sftpa1RatHydrops Fetalis  ISOSFTPA1 (Homo sapiens)4143453protein:decreased expression:lungRGD 
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Original Reference(s)
Sftpa1Ratchromosome 16p11.2 deletion syndrome, 593-kb  ISOSFTPA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Proximal 16p11.2 microdeletion syndromeClinVarPMID:25741868
Sftpa1RatHyaline Membrane Disease  ISOSFTPA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Respiratory distress associated with prematurityClinVarPMID:24033266|PMID:25741868
Sftpa1Ratidiopathic pulmonary fibrosis  ISOSFTPA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary fibrosis, idiopathic, susceptibility toClinVarPMID:13680361|PMID:24033266|PMID:25741868
Sftpa1Ratinterstitial lung disease 1  ISOSFTPA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Interstitial lung disease 1 | ClinVar Annotator: match by term: more ...ClinVarPMID:13680361|PMID:17407567|PMID:21310059|PMID:24033266|PMID:25741868|PMID:26792177|PMID:28492532|PMID:30854216|PMID:31601679|PMID:32855221
Sftpa1Ratinterstitial lung disease 2  ISOSFTPA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Interstitial lung disease 2ClinVarPMID:25741868
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Original Reference(s)
Sftpa1Ratinterstitial lung disease 1  ISOSFTPA1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Sftpa1Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA]CTDPMID:25215149
Sftpa1Rat(S)-nicotine increases expressionISOSftpa1 (Mus musculus)6480464Nicotine results in increased expression of SFTPA1 mRNACTDPMID:9458815
Sftpa1Rat(S)-nicotine multiple interactionsISOSftpa1 (Mus musculus)6480464Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]CTDPMID:9458815
Sftpa1Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of SFTPA1 mRNACTDPMID:27840820
Sftpa1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOSftpa1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of SFTPA1 mRNACTDPMID:19372248
Sftpa1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SFTPA1 mRNACTDPMID:18990726
Sftpa1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of SFTPA1 mRNACTDPMID:22504374
Sftpa1Ratambroxol multiple interactionsEXP 6480464Ambroxol inhibits the reaction [Paraquat results in decreased expression of SFTPA1 protein]CTDPMID:16824340
Sftpa1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of SFTPA1 mRNACTDPMID:16483693
Sftpa1Ratanthra[1,9-cd]pyrazol-6(2H)-one multiple interactionsISOSFTPA1 (Homo sapiens)6480464pyrazolanthrone inhibits the reaction [Silicon Dioxide results in decreased expression of SFTPA1 protein]CTDPMID:35689653
Sftpa1RatATP multiple interactionsISOSFTPA1 (Homo sapiens)6480464[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in more ...CTDPMID:15065867
Sftpa1Ratbenzo[a]pyrene decreases expressionISOSftpa1 (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of SFTPA1 mRNACTDPMID:22228805
Sftpa1Ratbenzo[a]pyrene affects methylationISOSFTPA1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of SFTPA1 promoterCTDPMID:27901495
Sftpa1Ratbenzo[a]pyrene increases methylationISOSFTPA1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of SFTPA1 3' UTR; Benzo(a)pyrene results in increased methylation of more ...CTDPMID:27901495
Sftpa1Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of SFTPA1 geneCTDPMID:28505145
Sftpa1Ratbisphenol F decreases expressionISOSftpa1 (Mus musculus)6480464bisphenol F results in decreased expression of SFTPA1 mRNACTDPMID:38685157
Sftpa1Ratbleomycin A2 multiple interactionsISOSFTPA1 (Homo sapiens)6480464[Bleomycin co-treated with SFTPA1 protein polymorphism] results in increased expression of CXCL8 protein; [Bleomycin co-treated more ...CTDPMID:14617519
Sftpa1Ratbleomycin A2 increases expressionEXP 6480464Bleomycin results in increased expression of SFTPA1 proteinCTDPMID:25933445
Sftpa1Ratbleomycin A2 decreases expressionEXP 6480464Bleomycin results in decreased expression of SFTPA1 mRNACTDPMID:15782499
Sftpa1Ratbosentan multiple interactionsEXP 6480464Bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPA1 mRNA]; Bosentan more ...CTDPMID:15640287

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Biological Process
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Cellular Component
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Original Reference(s)
Sftpa1Ratcollagen trimer part_ofIEAUniProtKB-KW:KW-01761600115GO_REF:0000043UniProtGO_REF:0000043
Sftpa1Ratcytoplasmic vesicle located_inIEAARBA:ARBA000271901600115GO_REF:0000117UniProtGO_REF:0000117
Sftpa1Ratendomembrane system located_inIEAARBA:ARBA000289531600115GO_REF:0000117UniProtGO_REF:0000117
Sftpa1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-0112|UniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Sftpa1Ratextracellular region located_inIEAUniProtKB-KW:KW-07671600115GO_REF:0000043UniProtGO_REF:0000043
Sftpa1Ratextracellular region located_inIEAARBA:ARBA000271281600115GO_REF:0000117UniProtGO_REF:0000117
Sftpa1Ratextracellular space  IDA 4143429 RGD 
Sftpa1Ratextracellular space is_active_inIBAMGI:96923|MGI:96924|PANTHER:PTN002369884|RGD:3055|RGD:3665|RGD:3667|RGD:67380|UniProtKB:P11226|UniProtKB:Q9BWP8|UniProtKB:Q9Y6Z71600115GO_REF:0000033GO_CentralGO_REF:0000033
Sftpa1Ratmultivesicular body  IDA 4143471 RGD 
Sftpa1Ratmultivesicular body is_active_inIBAPANTHER:PTN002771384|RGD:3665|RGD:36671600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function

  
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Original Reference(s)
Sftpa1Ratcarbohydrate binding enablesIEAUniProtKB-KW:KW-04301600115GO_REF:0000043UniProtGO_REF:0000043
Sftpa1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Sftpa1Ratprotein binding enablesISOSFTPA1 (Homo sapiens)1624291UniProtKB:P75409|UniProtKB:Q9UGM3 PMID:10101009, PMID:15845487RGDPMID:10101009|PMID:15845487

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Sftpa1Ratphagocytosis pathway  IEA 6907045 KEGGrno:04145

Imported Annotations - PID (archival)

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Original Reference(s)
Sftpa1Ratforkhead class A signaling pathway  ISOSFTPA1 (Homo sapiens)6484113 PIDPID:200226

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#
Reference Title
Reference Citation
1. Surfactant protein deficiency in familial interstitial lung disease. Amin RS, etal., J Pediatr. 2001 Jul;139(1):85-92.
2. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. Atochina EN, etal., J Lab Clin Med. 2001 Jun;137(6):429-39.
3. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Atochina EN, etal., Respir Res. 2003 Dec 8;4:15. Print 2003.
4. Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages. Beharka AA, etal., J Immunol 2002 Oct 1;169(7):3565-73.
5. Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF). Boon K, etal., PLoS One. 2009;4(4):e5134. Epub 2009 Apr 6.
6. [Effect of intrauterine acute ischemic-hypoxia on the expression of lung SP-A and SP-B in neonatal rats] Cai XX, etal., Zhonghua Er Ke Za Zhi. 2003 Mar;41(3):208-11.
7. Mild vitamin A deficiency delays fetal lung maturation in the rat. Chailley-Heu B, etal., Am J Respir Cell Mol Biol. 1999 Jul;21(1):89-96.
8. Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis. Choi EH, etal., Pediatr Pulmonol. 2006 Mar;41(3):255-62.
9. Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration. Cleary GM, etal., Pediatrics. 1997 Dec;100(6):998-1003.
10. Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma. Erpenbeck VJ, etal., Allergy. 2006 May;61(5):598-604.
11. Rat pulmonary surfactant protein A is expressed as two differently sized mRNA species which arise from differential polyadenylation of one transcript. Fisher JH, etal., Biochim Biophys Acta 1988 Sep 7;950(3):338-45.
12. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Fujita M, etal., Cytokine. 2005 Jul 7;31(1):25-33.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Relationship between pulmonary surfactant protein and lipid peroxidation in lung injury due to paraquat intoxication in rats. Gil HW, etal., Korean J Intern Med. 2007 Jun;22(2):67-72.
15. Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Greene KE, etal., Am J Respir Crit Care Med. 1999 Dec;160(6):1843-50.
16. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Griese M, etal., Am J Respir Crit Care Med. 2004 Nov 1;170(9):1000-5. Epub 2004 Jul 21.
17. Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats. Guarino N, etal., J Pediatr Surg. 2000 Oct;35(10):1468-73. doi: 10.1053/jpsu.2000.16416.
18. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Gunther A, etal., Am J Respir Crit Care Med. 1996 Jan;153(1):176-84.
19. Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis. Gunther A, etal., Eur Respir J. 1999 Sep;14(3):565-73.
20. Surfactant protein gene A, B, and D marker alleles in chronic obstructive pulmonary disease of a Mexican population. Guo X, etal., Eur Respir J. 2001 Sep;18(3):482-90.
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PMID:3579914   PMID:12477932   PMID:12600986   PMID:12857753   PMID:12882765   PMID:12904592   PMID:12913002   PMID:14993215   PMID:15482851   PMID:15489334   PMID:15969762   PMID:16081790  
PMID:16207426   PMID:16330552   PMID:16500946   PMID:17202387   PMID:17220308   PMID:17469149   PMID:18344412   PMID:18480979   PMID:20382745   PMID:20473679   PMID:20663300   PMID:20688121  
PMID:21047777   PMID:21123169   PMID:21166190   PMID:21248257   PMID:23894445   PMID:25242514   PMID:26196539   PMID:27660222   PMID:28719181   PMID:30055742   PMID:33267655   PMID:34777371  
PMID:38483982  



Sftpa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,042,264 - 17,045,770 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1617,042,255 - 17,045,769 (+)EnsemblGRCr8
mRatBN7.21617,008,180 - 17,011,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,008,180 - 17,011,685 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1617,072,970 - 17,076,475 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,199,439 - 18,202,946 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,125,874 - 17,129,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,716,019 - 18,719,404 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,716,019 - 18,719,403 (+)Ensemblrn6Rnor6.0
Rnor_5.01618,585,631 - 18,589,016 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41617,570,887 - 17,574,389 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1617,235,343 - 17,236,847 (+)NCBICelera
Cytogenetic Map16p14NCBI
SFTPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381079,610,939 - 79,615,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1079,610,412 - 79,616,115 (+)Ensemblhg38GRCh38
GRCh371081,370,695 - 81,375,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361081,040,722 - 81,045,208 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341081,360,663 - 81,363,921NCBI
Celera1074,655,786 - 74,660,290 (+)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1075,365,719 - 75,370,230 (+)NCBIHuRef
CHM1_11081,653,316 - 81,657,819 (+)NCBICHM1_1
T2T-CHM13v2.01080,480,108 - 80,484,632 (+)NCBIT2T-CHM13v2.0
Sftpa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,853,745 - 40,858,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,853,739 - 40,858,409 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381441,131,788 - 41,136,373 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,131,782 - 41,136,452 (+)Ensemblmm10GRCm38
MGSCv371441,945,077 - 41,949,662 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361440,040,501 - 40,045,086 (+)NCBIMGSCv36mm8
Celera1437,291,836 - 37,296,421 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
LOC103783265
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2892,137,770 - 92,140,202 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11092,143,130 - 92,145,527 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01076,571,312 - 76,575,820 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11080,176,241 - 80,177,151 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC610540
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,430,139 - 29,434,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,554,528 - 29,559,038 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0429,732,348 - 29,736,864 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1429,601,811 - 29,606,320 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,804,500 - 29,809,005 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,158,495 - 30,163,007 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SFTPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1482,091,178 - 82,095,393 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11482,091,178 - 82,095,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21488,698,851 - 88,702,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3

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Variants in Sftpa1
154 total Variants

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:148
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000047870
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat

1 to 10 of 25 rows
D16Mgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81617,041,660 - 17,041,828 (+)Marker Load Pipeline
mRatBN7.21617,007,576 - 17,007,744 (+)MAPPERmRatBN7.2
Rnor_6.01618,715,416 - 18,715,583NCBIRnor6.0
Rnor_5.01618,585,028 - 18,585,195UniSTSRnor5.0
RGSC_v3.41617,570,281 - 17,570,446RGDRGSC3.4
RGSC_v3.41617,570,282 - 17,570,449UniSTSRGSC3.4
RGSC_v3.11617,570,279 - 17,570,444RGD
RH 3.4 Map16170.6UniSTS
RH 3.4 Map16170.6RGD
RH 2.0 Map16142.7RGD
SHRSP x BN Map165.71RGD
FHH x ACI Map1612.1799RGD
Cytogenetic Map16p14UniSTS
RH136969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,011,434 - 17,011,625 (+)MAPPERmRatBN7.2
Rnor_6.01618,719,153 - 18,719,343NCBIRnor6.0
Rnor_5.01618,588,765 - 18,588,955UniSTSRnor5.0
RGSC_v3.41617,574,140 - 17,574,330UniSTSRGSC3.4
Celera1617,236,596 - 17,236,786UniSTS
RH 3.4 Map16167.1UniSTS
Cytogenetic Map16p14UniSTS
Sftpa1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01618,717,098 - 18,717,980NCBIRnor6.0
Rnor_5.01618,586,710 - 18,587,592UniSTSRnor5.0
RGSC_v3.41617,571,964 - 17,572,967UniSTSRGSC3.4
Cytogenetic Map16p14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
9 9 21 31 73 80 49 50 49 2 161 85 4 18 10 23 31



Ensembl Acc Id: ENSRNOT00000047870   ⟹   ENSRNOP00000039850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1617,042,255 - 17,045,769 (+)Ensembl
mRatBN7.2 Ensembl1617,008,180 - 17,011,685 (+)Ensembl
Rnor_6.0 Ensembl1618,716,019 - 18,719,403 (+)Ensembl
RefSeq Acc Id: NM_001270645   ⟹   NP_001257574
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,042,264 - 17,045,770 (+)NCBI
mRatBN7.21617,008,180 - 17,011,686 (+)NCBI
Rnor_6.01618,716,019 - 18,719,404 (+)NCBI
Rnor_5.01618,585,631 - 18,589,016 (+)NCBI
Celera1617,235,343 - 17,236,847 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270647   ⟹   NP_001257576
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,042,264 - 17,045,770 (+)NCBI
mRatBN7.21617,008,180 - 17,011,686 (+)NCBI
Rnor_6.01618,716,019 - 18,719,404 (+)NCBI
Rnor_5.01618,585,631 - 18,589,016 (+)NCBI
Celera1617,235,343 - 17,236,847 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017329   ⟹   NP_059025
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,042,264 - 17,045,770 (+)NCBI
mRatBN7.21617,008,180 - 17,011,686 (+)NCBI
Rnor_6.01618,716,019 - 18,719,404 (+)NCBI
Rnor_5.01618,585,631 - 18,589,016 (+)NCBI
RGSC_v3.41617,570,887 - 17,574,389 (+)RGD
Celera1617,235,343 - 17,236,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094199   ⟹   XP_038950127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,042,377 - 17,045,770 (+)NCBI
mRatBN7.21617,008,293 - 17,011,686 (+)NCBI
RefSeq Acc Id: NP_059025   ⟸   NM_017329
- Peptide Label: isoform 2 precursor
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257574   ⟸   NM_001270645
- Peptide Label: isoform 1 precursor
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257576   ⟸   NM_001270647
- Peptide Label: isoform 3 precursor
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039850   ⟸   ENSRNOT00000047870
RefSeq Acc Id: XP_038950127   ⟸   XM_039094199
- Peptide Label: isoform X1
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
C-type lectin   Collagen-like

Name Modeler Protein Id AA Range Protein Structure
AF-P08427-F1-model_v2 AlphaFold P08427 1-248 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699975
Promoter ID:EPDNEW_R10497
Type:multiple initiation site
Name:Sftpa1_1
Description:surfactant protein A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01618,716,010 - 18,716,070EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11908 BioCyc
Ensembl Genes ENSRNOG00000011438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047870 ENTREZGENE
  ENSRNOT00000047870.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121530 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Ca-dependent_lectin UniProtKB/Swiss-Prot
  Collectin_CTLD UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
KEGG Report rno:24773 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105453 IMAGE-MGC_LOAD
NCBI Gene 24773 ENTREZGENE
PANTHER PULMONARY SURFACTANT-ASSOCIATED PROTEIN A UniProtKB/Swiss-Prot
  PULMONARY SURFACTANT-ASSOCIATED PROTEIN A1 UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot
PhenoGen Sftpa1 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011438 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
  Triple coiled coil domain of C-type lectins UniProtKB/Swiss-Prot
UniProt A6K9L7_RAT UniProtKB/TrEMBL
  P08427 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-18 Sftpa1  surfactant protein A1  LOC102557073  pulmonary surfactant-associated protein A-like  Data merged from RGD:7634712 737654 APPROVED
2013-12-18 LOC102557073  pulmonary surfactant-associated protein A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-03-29 Sftpa1  surfactant protein A1  LOC100364823  pulmonary surfactant-associated protein A-like  Data merged from RGD:2320242 737654 PROVISIONAL
2010-05-05 LOC100364823  pulmonary surfactant-associated protein A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-02-26 Sftpa1  surfactant protein A1  Sftpa1  surfactant, pulmonary-associated protein A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Sftpa1  surfactant, pulmonary-associated protein A1    Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A)  Name updated 629478 APPROVED