C5orf67 (chromosome 5 putative open reading frame 67)

Gene: C5orf67 (chromosome 5 putative open reading frame 67) Homo sapiens

Analyze

Symbol:

C5orf67

Name:

chromosome 5 putative open reading frame 67

RGD ID:

9836383

HGNC Page

HGNC:51252

Description:

INTERACTS WITH aflatoxin B1; benzo[e]pyrene; lipopolysaccharide

Type:

ncrna (Ensembl: lncRNA)

RefSeq Status:

VALIDATED

Previously known as:

chromosome 5 open reading frame 67; Uncharacterized protein C5orf67; uncharacterized protein LOC101928448

RGD Orthologs

Bonobo

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	56,511,282 - 56,606,256 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	56,511,567 - 56,606,232 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	55,807,109 - 55,902,083 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	5	q11.2	NCBI
HuRef	5	52,781,159 - 52,802,436 (-)	NCBI		HuRef
CHM1_1	5	55,812,687 - 55,833,979 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	57,339,221 - 57,434,172 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

aflatoxin B1 (EXP)

benzo[e]pyrene (EXP)

lipopolysaccharide (EXP)

methapyrilene (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

References

Additional References at PubMed

PMID:15372022	PMID:20686565	PMID:20864672	PMID:23263486	PMID:23754948	PMID:23966867	PMID:24097068	PMID:24204828	PMID:31928498

Genomics

Comparative Map Data

C5orf67
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	56,511,282 - 56,606,256 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	56,511,567 - 56,606,232 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	55,807,109 - 55,902,083 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	5	q11.2	NCBI
HuRef	5	52,781,159 - 52,802,436 (-)	NCBI		HuRef
CHM1_1	5	55,812,687 - 55,833,979 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	57,339,221 - 57,434,172 (-)	NCBI		T2T-CHM13v2.0

LOC103783109
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	57,395,413 - 57,419,907 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	55,549,044 - 55,573,538 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	57,461,083 - 57,508,019 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	59,039,676 - 59,134,362 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

Variants

Variants in C5orf67
42 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 5q11.1-12.1(chr5:50288355-63149770)x1	copy number loss	See cases [RCV000050797]	Chr5:50288355..63149770 [GRCh38] Chr5:49584189..62445597 [GRCh37] Chr5:49619946..62481353 [NCBI36] Chr5:5q11.1-12.1	pathogenic
GRCh38/hg38 5q11.1-11.2(chr5:50288355-56717370)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051838]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051838]\|See cases [RCV000051838]	Chr5:50288355..56717370 [GRCh38] Chr5:49584189..56013197 [GRCh37] Chr5:49619946..56048954 [NCBI36] Chr5:5q11.1-11.2	pathogenic
GRCh38/hg38 5q11.2(chr5:53332485-57152396)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053283]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053283]\|See cases [RCV000053283]	Chr5:53332485..57152396 [GRCh38] Chr5:52628315..56448223 [GRCh37] Chr5:52664072..56483980 [NCBI36] Chr5:5q11.2	uncertain significance
GRCh38/hg38 5p13.2-q12.1(chr5:35201559-61903141)x3	copy number gain	See cases [RCV000137302]	Chr5:35201559..61903141 [GRCh38] Chr5:35201661..61198968 [GRCh37] Chr5:35237418..61234725 [NCBI36] Chr5:5p13.2-q12.1	pathogenic
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3	copy number gain	See cases [RCV000138780]	Chr5:22149..74412725 [GRCh38] Chr5:22149..73708550 [GRCh37] Chr5:75149..73744306 [NCBI36] Chr5:5p15.33-q13.3	pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	163
Count of miRNA genes:	162
Interacting mature miRNAs:	162
Transcripts:	ENST00000438651
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

entire extraembryonic component

High

Medium

Low

179

623

714

953

620

319

218

215

811

399

Below cutoff

1258

1181

486

287

411

167

2098

808

2420

104

879

526

128

774

1243

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NR_161255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC022431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX089473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000611197

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	56,511,722 - 56,535,230 (-)	Ensembl

RefSeq Acc Id:

ENST00000648716

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	56,511,567 - 56,606,232 (-)	Ensembl

RefSeq Acc Id:

NR_161255

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	5	56,511,282 - 56,606,256 (-)	NCBI
T2T-CHM13v2.0	5	57,339,221 - 57,434,172 (-)	NCBI

Sequence:

show sequence

ATATTCCCTGTGCTCCCCTGGGATCAACAGCCAAATGAACAACTTCACCTGAGCCCTTACCTCC
AAGGAAGTGCCACAGGGGAACCCAAAGGCCCTTAATCATTAAAAAAAACTTTAGAGATGCTGGC
TGAGCCATCAGTGAGAACATGGATGCATACACAGAACCTACATCTTGTCATCTCTGCTCTTCGA
GGAATGGAGCTGGAGAGGCAGAGAAGCAATGAAGCCGAATTCTGAGTAGTATACTCTGATGAAG
AGGATATTTTACAAGCATAGAAAAAGGAGGGCTCCAGTCTTCAAAGAACCAGAGCATGGGTACC
AAAGCCTCCCAGAGCTAGTTCTGGTCCCAGCTCAGCCACTTGTCTGTTTGGGTGACTATAGAAC
TCCAGATCCAGGTGGGCTCTTTCCATGGAGCCTGAGACTTATGATGCCAGGTGCCTGGACAAAG
CTTCCAGGTGATGGTGGCAGTGTCCCAGAGAAGGGAAAGCATGGCATTCTGGGAGCACAGGGCC
AGGAGCACCCGGGTTTGAATGTCAGCTCCCCGTTTTCCAGCCCTTGGACGTGTTACCTGTCTGG
ACATCAGCCTCAGAATAATAATAGCCCTGAGCTTCAGGTTAAGGAAATCCTCTTATGAGATAGA
GCTCAGCTCCTCCTGTAGAAGCTGAAATTCCAGACACTGGACTTCCCAGTCTCCCTTGCCACTA
GATATGGACACGTGATCAAGATTCCACCAATCAGATGGTCTTTGAATCTGCTAGTGACAAAAAG
AAAGGAACATGCCAAATCCATTCTGGCAGATTTAAGACACAATGGCAGCTACATCCAGTTCCCA
GAGGCAGCAGGGCCAGTGGTTCTAGCATCGGCATCCAAGAACACTTGCTGATGGTGCAGATGGT
GTGAGCTGCAGTGTCCAGGTGCAGTATGGCTGCTATGGTGTCCTCAATGAATGAATCCTGCAGT
GGAATTTACAGTGTTGTTCCTGGCTGCACAGTCTTCAAGCCTTTTTCTCTGGATACTCTAGGAA
TTCTTTGAGTTTCCCAGTGTCCTTTCAATAAATTCTTCTTCCTAAATTAA

hide sequence

Protein Sequences


GenBank Protein	F2Z3F1	(Get FASTA)	NCBI Sequence Viewer

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F2Z3F1-F1-model_v2	AlphaFold	F2Z3F1	1-127	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	C5orf67	COSMIC
Ensembl Genes	ENSG00000225940	Ensembl
GTEx	ENSG00000225940	GTEx
HGNC ID	HGNC:51252	ENTREZGENE
Human Proteome Map	C5orf67	Human Proteome Map
NCBI Gene	C5orf67	ENTREZGENE
PharmGKB	PA166180571	PharmGKB
RNAcentral	URS0000E60A56	RNACentral
UniProt	CE067_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-08-10	C5orf67	chromosome 5 putative open reading frame 67	C5orf67	chromosome 5 open reading frame 67	Symbol and/or name change	19259463	PROVISIONAL
2020-08-03	C5orf67	chromosome 5 open reading frame 67	C5orf67	chromosome 5 putative open reading frame 67	Symbol and/or name change	19259463	PROVISIONAL
2019-11-05	C5orf67	chromosome 5 putative open reading frame 67	C5orf67	chromosome 5 open reading frame 67	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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