SPDYE15 (speedy/RINGO cell cycle regulator family member E15) - Rat Genome Database

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Gene: SPDYE15 (speedy/RINGO cell cycle regulator family member E15) Homo sapiens
Analyze
No known orthologs.
Symbol: SPDYE15
Name: speedy/RINGO cell cycle regulator family member E15
RGD ID: 9686174
HGNC Page HGNC:51511
Description: Predicted to enable protein kinase binding activity.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC211486.6; novel speedy/RINGO cell cycle regulator family member; putative speedy protein E15; SPDYE15P; speedy homolog E1 pseudogene; speedy/RINGO cell cycle regulator family member E1 pseudogene; speedy/RINGO cell cycle regulator family member E15, pseudogene; Williams Beuren syndrome chromosome region 19 pseudogene
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,335,343 - 75,347,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl775,335,343 - 75,345,396 (+)EnsemblGRCh38hg38GRCh38
GRCh37774,964,556 - 74,974,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7q11.23NCBI
CHM1_1774,897,503 - 74,904,800 (+)NCBICHM1_1
T2T-CHM13v2.0776,538,563 - 76,548,628 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:21873635  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q11.23(chr7:75065669-75704220)x1 copy number loss See cases [RCV000050808] Chr7:75065669..75704220 [GRCh38]
Chr7:74481481..75217572 [GRCh37]
Chr7:74119417..75171474 [NCBI36]
Chr7:7q11.23		 uncertain significance
GRCh38/hg38 7q11.23(chr7:73352304-76722261)x1 copy number loss See cases [RCV000133638] Chr7:73352304..76722261 [GRCh38]
Chr7:72766313..76351578 [GRCh37]
Chr7:72404249..76189514 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:72649515-75361855)x3 copy number gain See cases [RCV000051965] Chr7:72649515..75361855 [GRCh38]
Chr7:72196405..74991125 [GRCh37]
Chr7:71752436..74829061 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7q11.23(chr7:75331937-75352753)x3 copy number gain See cases [RCV000139752] Chr7:75331937..75352753 [GRCh38]
Chr7:72479259..72503760 [GRCh37]
Chr7:72117195..72141696 [NCBI36]
Chr7:7q11.23		 likely benign
GRCh38/hg38 7q11.21-11.23(chr7:62977085-75415352)x3 copy number gain See cases [RCV000142242] Chr7:62977085..75415352 [GRCh38]
Chr7:62437463..75044630 [GRCh37]
Chr7:62074898..74882566 [NCBI36]
Chr7:7q11.21-11.23		 pathogenic
GRCh38/hg38 7q11.23-21.11(chr7:73873420-83988860)x1 copy number loss See cases [RCV000054118] Chr7:73873420..83988860 [GRCh38]
Chr7:73992744..83618176 [GRCh37]
Chr7:72925686..83456112 [NCBI36]
Chr7:7q11.23-21.11		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q11.23(chr7:74176025-75361855)x1 copy number loss See cases [RCV000054121] Chr7:74176025..75361855 [GRCh38]
Chr7:73992744..74991125 [GRCh37]
Chr7:73228291..74829061 [NCBI36]
Chr7:7q11.23		 pathogenic
GRCh38/hg38 7q11.21-11.23(chr7:62736364-75432710)x1 copy number loss See cases [RCV000142528] Chr7:62736364..75432710 [GRCh38]
Chr7:62196742..75061986 [GRCh37]
Chr7:61834177..74899922 [NCBI36]
Chr7:7q11.21-11.23		 pathogenic
GRCh38/hg38 7q11.22-21.11(chr7:72179092-79164071) copy number gain See cases [RCV000143454] Chr7:72179092..79164071 [GRCh38]
Chr7:71644077..78793387 [GRCh37]
Chr7:71282013..78631323 [NCBI36]
Chr7:7q11.22-21.11		 likely pathogenic
GRCh38/hg38 7q11.22-21.11(chr7:71225344-81735657)x1 copy number loss See cases [RCV000050709] Chr7:71225344..81735657 [GRCh38]
Chr7:70690330..81364973 [GRCh37]
Chr7:70328266..81202909 [NCBI36]
Chr7:7q11.22-21.11		 pathogenic
GRCh38/hg38 7q11.22-11.23(chr7:69382353-77823832)x1 copy number loss See cases [RCV000054111] Chr7:69382353..77823832 [GRCh38]
Chr7:68847339..77453149 [GRCh37]
Chr7:68485275..77291085 [NCBI36]
Chr7:7q11.22-11.23		 pathogenic
GRCh38/hg38 7q11.23-21.11(chr7:74377395-82031742)x1 copy number loss See cases [RCV000142381] Chr7:74377395..82031742 [GRCh38]
Chr7:73992744..81661058 [GRCh37]
Chr7:73429661..81498994 [NCBI36]
Chr7:7q11.23-21.11		 pathogenic
NC_000007.14:g.(75058300_?)_(?_79083658)del deletion Distal 7q11.23 microdeletion syndrome [RCV001839073] Chr7:75058300..79083658 [GRCh38]
Chr7:7q11.23-21.11		 pathogenic

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000612377   ⟹   ENSP00000499200
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl775,335,343 - 75,345,396 (+)Ensembl
RefSeq Acc Id: NM_001382547   ⟹   NP_001369476
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38775,335,343 - 75,345,396 (+)NCBI
T2T-CHM13v2.0776,538,563 - 76,548,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047419778   ⟹   XP_047275734
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38775,336,685 - 75,347,701 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001369476 (Get FASTA)   NCBI Sequence Viewer  
  XP_047275734 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000499200
  ENSP00000499200.1
GenBank Protein P0DUD4 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001369476   ⟸   NM_001382547
- UniProtKB: P0DUD4 (UniProtKB/Swiss-Prot),   P0DUD3 (UniProtKB/Swiss-Prot),   A0A494C0Z2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047275734   ⟸   XM_047419778
- Peptide Label: isoform X1
- UniProtKB: P0DUD4 (UniProtKB/Swiss-Prot),   P0DUD3 (UniProtKB/Swiss-Prot),   A0A494C0Z2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSP00000499200   ⟸   ENST00000612377

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DUD4-F1-model_v2 AlphaFold P0DUD4 1-265 view protein structure


Additional Information

Database Acc Id Source(s)
COSMIC SPDYE15 COSMIC
Ensembl Genes ENSG00000286014 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000612377 ENTREZGENE
  ENST00000612377.3 UniProtKB/Swiss-Prot
GTEx ENSG00000286014 GTEx
HGNC ID HGNC:51511 ENTREZGENE
Human Proteome Map SPDYE15 Human Proteome Map
InterPro Speedy UniProtKB/Swiss-Prot
NCBI Gene SPDYE15P ENTREZGENE
PANTHER PTHR31156 UniProtKB/Swiss-Prot
  SPEEDY PROTEIN E2-RELATED UniProtKB/Swiss-Prot
Pfam Spy1 UniProtKB/Swiss-Prot
UniProt A0A494C0Z2 ENTREZGENE
  P0DUD3 ENTREZGENE
  P0DUD4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-07 SPDYE15  speedy/RINGO cell cycle regulator family member E15  AC211486.6  novel speedy/RINGO cell cycle regulator family member  Data merged from RGD:16571164 737654 PROVISIONAL
2019-11-26 SPDYE15  speedy/RINGO cell cycle regulator family member E15  SPDYE15P  speedy/RINGO cell cycle regulator family member E15, pseudogene  Symbol and/or name change 5135510 APPROVED