MIR3181 (microRNA 3181) - Rat Genome Database
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Gene: MIR3181 (microRNA 3181) Homo sapiens
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Symbol: MIR3181
Name: microRNA 3181
RGD ID: 9685697
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,742,305 - 50,742,377 (+)EnsemblGRCh38hg38GRCh38
GRCh381650,742,305 - 50,742,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,776,216 - 50,776,288 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map16q12.1NCBI
CHM1_11652,183,742 - 52,183,814 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:20300190   PMID:29302759  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PHACTR3hsa-miR-3181Mirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:35789
Count of gene targets:14874
Count of transcripts:34688
Interacting mature miRNAs:hsa-miR-3181
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 3 27 2 1 1 1 1 1
Low 70 13 57 31 231 33 115 47 73 51 103 137 7 5 14 1
Below cutoff 16 5 3 2 7 3 8 10 13 5 10 11 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000578512
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1650,742,305 - 50,742,377 (+)Ensembl
RefSeq Acc Id: NR_130462
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381650,742,305 - 50,742,377 (+)NCBI
CHM1_11652,183,742 - 52,183,814 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52355793)x3 copy number gain See cases [RCV000137170] Chr16:46466829..52355793 [GRCh38]
Chr16:46500741..52389705 [GRCh37]
Chr16:45058242..50947206 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52422170)x1 copy number loss See cases [RCV000137306] Chr16:46466829..52422170 [GRCh38]
Chr16:46500741..52456082 [GRCh37]
Chr16:45058242..51013583 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q12.1-12.2(chr16:49570553-53467065)x1 copy number loss See cases [RCV000137722] Chr16:49570553..53467065 [GRCh38]
Chr16:49604464..53500977 [GRCh37]
Chr16:48161965..52058478 [NCBI36]
Chr16:16q12.1-12.2
pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46471520-52405956)x1 copy number loss See cases [RCV000053328] Chr16:46471520..52405956 [GRCh38]
Chr16:46505432..52439868 [GRCh37]
Chr16:45062933..50997369 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q12.1-12.2(chr16:47250644-54121476)x1 copy number loss See cases [RCV000053329] Chr16:47250644..54121476 [GRCh38]
Chr16:47284555..54155388 [GRCh37]
Chr16:45842056..52712889 [NCBI36]
Chr16:16q12.1-12.2
pathogenic
GRCh38/hg38 16q12.1(chr16:48156593-52220374)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053330]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053330]|See cases [RCV000053330] Chr16:48156593..52220374 [GRCh38]
Chr16:48190504..52254286 [GRCh37]
Chr16:46748005..50811787 [NCBI36]
Chr16:16q12.1
pathogenic
GRCh38/hg38 16q12.1(chr16:49740807-51876620)x1 copy number loss See cases [RCV000053331] Chr16:49740807..51876620 [GRCh38]
Chr16:49774718..51910531 [GRCh37]
Chr16:48332219..50468032 [NCBI36]
Chr16:16q12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-51939304)x1 copy number loss See cases [RCV000053309] Chr16:46466829..51939304 [GRCh38]
Chr16:46500741..51973216 [GRCh37]
Chr16:45058242..50530717 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-51673196)x1 copy number loss See cases [RCV000053310] Chr16:46466829..51673196 [GRCh38]
Chr16:46500741..51707107 [GRCh37]
Chr16:45058242..50264608 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52314178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052404]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052404]|See cases [RCV000052404] Chr16:46466829..52314178 [GRCh38]
Chr16:46500741..52348090 [GRCh37]
Chr16:45058242..50905591 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q12.1-12.2(chr16:48543083-53879916)x1 copy number loss Ductal breast carcinoma [RCV000207292] Chr16:48543083..53879916 [GRCh38]
Chr16:48576994..53913828 [GRCh37]
Chr16:16q12.1-12.2
uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR3181 COSMIC
Ensembl Genes ENSG00000264947 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578512 ENTREZGENE
GTEx ENSG00000264947 GTEx
HGNC ID HGNC:38378 ENTREZGENE
Human Proteome Map MIR3181 Human Proteome Map
miRBase MI0014223 ENTREZGENE
NCBI Gene MIR3181 ENTREZGENE
PharmGKB PA165450197 PharmGKB
RNAcentral URS00007E410F RNACentral
  URS00007E4A17 RNACentral