Strit1 (small transmembrane regulator of ion transport 1) - Rat Genome Database

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Gene: Strit1 (small transmembrane regulator of ion transport 1) Mus musculus
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Symbol: Strit1
Name: small transmembrane regulator of ion transport 1
RGD ID: 9592078
MGI Page MGI
Description: Enables enzyme activator activity. Involved in positive regulation of calcium ion transport and regulation of striated muscle contraction. Acts upstream of or within positive regulation of calcium ion import. Located in sarcoplasmic reticulum membrane. Orthologous to human STRIT1 (small transmembrane regulator of ion transport 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DWORF; Gm34302; predicted gene, 34302; Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; SERCA regulator DWORF
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39363,388,516 - 63,391,327 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl363,388,533 - 63,391,300 (-)EnsemblGRCm39 Ensembl
GRCm38363,481,095 - 63,483,906 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl363,481,112 - 63,483,879 (-)EnsemblGRCm38mm10GRCm38
Celera363,154,551 - 63,157,363 (-)NCBICelera
Cytogenetic Map3E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References
Additional References at PubMed
PMID:26816378   PMID:30299255   PMID:38334971  


Genomics

Comparative Map Data
Strit1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39363,388,516 - 63,391,327 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl363,388,533 - 63,391,300 (-)EnsemblGRCm39 Ensembl
GRCm38363,481,095 - 63,483,906 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl363,481,112 - 63,483,879 (-)EnsemblGRCm38mm10GRCm38
Celera363,154,551 - 63,157,363 (-)NCBICelera
Cytogenetic Map3E1NCBI
STRIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383155,290,227 - 155,293,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3155,290,227 - 155,293,683 (-)EnsemblGRCh38hg38GRCh38
GRCh373155,008,016 - 155,011,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3q25.2NCBI
HuRef3152,402,230 - 152,405,698 (-)NCBIHuRef
CHM1_13154,971,058 - 154,974,543 (-)NCBICHM1_1
T2T-CHM13v2.03158,064,207 - 158,067,663 (-)NCBIT2T-CHM13v2.0
Strit1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82150,084,857 - 150,087,721 (-)NCBIGRCr8
mRatBN7.22147,935,219 - 147,938,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2147,935,222 - 147,938,083 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2154,629,554 - 154,632,416 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02152,679,003 - 152,681,865 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02147,311,691 - 147,314,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02154,030,401 - 154,033,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2154,030,237 - 154,033,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02173,418,567 - 173,421,475 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2142,221,795 - 142,224,659 (-)NCBICelera
Cytogenetic Map2q31NCBI
STRIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22153,203,629 - 153,209,586 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13153,208,359 - 153,214,323 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03152,346,768 - 152,351,244 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13160,398,665 - 160,402,152 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,399,367 - 160,402,051 (-)Ensemblpanpan1.1panPan2
STRIT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12349,131,218 - 49,134,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2349,131,221 - 49,134,942 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2349,006,134 - 49,027,054 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02349,764,376 - 49,785,339 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2349,764,379 - 49,768,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12349,350,344 - 49,371,236 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02349,400,356 - 49,421,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02349,683,533 - 49,704,426 (-)NCBIUU_Cfam_GSD_1.0
Strit1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560287,066,687 - 87,069,867 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365192,664,278 - 2,666,850 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
STRIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660418,116,308 - 8,120,073 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
14746977Manh53_mmandible shape 53 (mouse)33592528069925280Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33417074168170741Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33970410273704231Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33970410273704231Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33457610368576103Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33970410273704231Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33375204567752228Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33540742169407421Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33970410273704231Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33375204567752228Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33353546567535615Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33717974268716946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884389Skwq10_mskull length QTL 10, 16 week (mouse)34395443565307421Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000192926   ⟹   ENSMUSP00000147363
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl363,388,533 - 63,391,300 (-)Ensembl
GRCm38.p6 Ensembl363,481,112 - 63,483,879 (-)Ensembl
RefSeq Acc Id: NM_001369305   ⟹   NP_001356234
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39363,388,516 - 63,391,327 (-)NCBI
GRCm38363,481,095 - 63,483,906 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001369306   ⟹   NP_001356235
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39363,388,516 - 63,391,327 (-)NCBI
GRCm38363,481,095 - 63,483,906 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001356234 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356235 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000147363
  ENSMUSP00000147363.2
GenBank Protein P0DN83 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001356235   ⟸   NM_001369306
- Peptide Label: isoform 2
- UniProtKB: P0DN83 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001356234   ⟸   NM_001369305
- Peptide Label: isoform 1
Ensembl Acc Id: ENSMUSP00000147363   ⟸   ENSMUST00000192926

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DN83-F1-model_v2 AlphaFold P0DN83 1-34 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:5593461 AgrOrtholog
Ensembl Genes ENSMUSG00000103476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000192926 ENTREZGENE
  ENSMUST00000192926.2 UniProtKB/Swiss-Prot
InterPro DWORF UniProtKB/Swiss-Prot
MGD MGI:5593461 ENTREZGENE
NCBI Gene Gm34302 ENTREZGENE
Pfam DWORF UniProtKB/Swiss-Prot
PhenoGen Strit1 PhenoGen
UniProt DWORF_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-09 Strit1  small transmembrane regulator of ion transport 1  Gm34302  predicted gene, 34302  Symbol and/or name change 5135510 APPROVED