Ndufc2<sup>em1Mcwi</sup> (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Ndufc2em1Mcwi (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Ndufc2em1Mcwi
Name: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 9588537
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 9-bp deletion in exon 1.
ASSOCIATED WITH failure of embryo implantation
Type: allele  of Ndufc2  
Previously known as: Ndufc2^[em1Mcwi]; Ndufc2em1Mcwi
Is Marker For: Strains:   SHR-Ndufc2em1Mcwi   SHR-Ndufc2em1Mcwi-/+  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. PhysGen Knockouts PhysGen Knockout strains
3. Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. Rubattu S, etal., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ndufc2em1Mcwi-var1 chr1 151712157 151712165 ACGGGCCTG - deletion mRatBN7.2
Ndufc2em1Mcwi-var1 chr1 162369993 162370001 ACGGGCCTG - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Ndufc2em1Mcwi
SHR-Ndufc2em1Mcwi-/+     SHR-Ndufc2em1Mcwi    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information