Pttg1ip2 (PTTG1IP family member 2) - Rat Genome Database

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Gene: Pttg1ip2 (PTTG1IP family member 2) Rattus norvegicus
Analyze
Symbol: Pttg1ip2
Name: PTTG1IP family member 2
RGD ID: 9118001
Description: Predicted to be located in membrane; INTERACTS WITH chlordecone (ortholog); chlorpyrifos (ortholog); sodium arsenite (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC103692048; uncharacterized LOC103692048; uncharacterized protein LOC103692048; uncharacterized protein Pttg1ip2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8429,515,113 - 29,555,197 (+)NCBIGRCr8
mRatBN7.2428,561,063 - 28,585,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl428,561,705 - 28,585,391 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0425,719,956 - 25,759,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl425,720,697 - 25,738,705 (+)EnsemblRnor6.0rn6Rnor6.0
Celera424,005,630 - 24,044,274 (+)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
membrane  (IEA)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Comparative Map Data
Pttg1ip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8429,515,113 - 29,555,197 (+)NCBIGRCr8
mRatBN7.2428,561,063 - 28,585,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl428,561,705 - 28,585,391 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0425,719,956 - 25,759,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl425,720,697 - 25,738,705 (+)EnsemblRnor6.0rn6Rnor6.0
Celera424,005,630 - 24,044,274 (+)NCBICelera
Cytogenetic Map4q13NCBI
PTTG1IP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38790,469,639 - 90,513,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl790,469,639 - 90,513,397 (+)EnsemblGRCh38hg38GRCh38
GRCh37790,098,953 - 90,142,711 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7q21.13NCBI
CHM1_1790,011,448 - 90,072,806 (+)NCBICHM1_1
T2T-CHM13v2.0791,717,921 - 91,761,664 (+)NCBIT2T-CHM13v2.0
Pttg1ip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3955,487,827 - 5,529,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl55,487,827 - 5,529,143 (-)EnsemblGRCm39 Ensembl
GRCm3855,437,827 - 5,479,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl55,437,827 - 5,479,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv3755,437,827 - 5,479,102 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3655,443,833 - 5,485,108 (-)NCBIMGSCv36mm8
Celera55,384,882 - 5,426,343 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.89NCBI
PTTG1IP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26108,371,183 - 108,414,631 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17156,635,822 - 156,659,338 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0782,483,882 - 82,507,312 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PTTG1IP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1415,902,681 - 15,937,269 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01416,138,042 - 16,172,657 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11416,300,085 - 16,334,723 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01416,018,511 - 16,053,091 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01416,303,331 - 16,337,968 (+)NCBIUU_Cfam_GSD_1.0
Pttg1ip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511829,750,040 - 29,777,637 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366213,567,025 - 3,618,477 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTTG1IP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1970,541,117 - 70,677,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTTG1IP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604245,760,815 - 45,810,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pttg1ip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248092,779,669 - 2,808,602 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pttg1ip2
225 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 7
Low 1 17 3
Below cutoff 1 2 2 1 2 2 3 4 4 6 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000088918   ⟹   ENSRNOP00000074762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl428,561,705 - 28,585,391 (+)Ensembl
Rnor_6.0 Ensembl425,720,697 - 25,738,705 (+)Ensembl
RefSeq Acc Id: XM_008762735   ⟹   XP_008760957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8429,515,113 - 29,540,208 (+)NCBI
mRatBN7.2428,561,063 - 28,585,400 (+)NCBI
Rnor_6.0425,719,956 - 25,744,288 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108580   ⟹   XP_038964508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8429,515,113 - 29,535,208 (+)NCBI
mRatBN7.2428,561,063 - 28,580,394 (+)NCBI
RefSeq Acc Id: XM_063286911   ⟹   XP_063142981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8429,515,113 - 29,535,208 (+)NCBI
RefSeq Acc Id: XR_010066086
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8429,515,113 - 29,555,197 (+)NCBI
RefSeq Acc Id: XR_010066087
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8429,515,113 - 29,542,194 (+)NCBI
RefSeq Acc Id: XR_592010
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8429,515,113 - 29,540,208 (+)NCBI
mRatBN7.2428,561,709 - 28,585,400 (+)NCBI
Rnor_6.0425,719,956 - 25,744,288 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008760957 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964508 (Get FASTA)   NCBI Sequence Viewer  
  XP_063142981 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074762
  ENSRNOP00000074762.2
Reference Protein Sequences
RefSeq Acc Id: XP_008760957   ⟸   XM_008762735
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K8W5 (UniProtKB/TrEMBL),   A6K263 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074762   ⟸   ENSRNOT00000088918
RefSeq Acc Id: XP_038964508   ⟸   XM_039108580
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142981   ⟸   XM_063286911
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8W5-F1-model_v2 AlphaFold A0A0G2K8W5 1-134 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692845
Promoter ID:EPDNEW_R3363
Type:initiation region
Name:LOC103692048_1
Description:uncharacterized LOC103692048
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0425,720,662 - 25,720,722EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9118001 AgrOrtholog
BioCyc Gene G2FUF-45792 BioCyc
Ensembl Genes ENSRNOG00000051419 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088918.2 UniProtKB/TrEMBL
KEGG Report rno:103692048 UniProtKB/TrEMBL
NCBI Gene LOC103692048 ENTREZGENE
PANTHER PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN UniProtKB/TrEMBL
  PROTEIN CBG20567 UniProtKB/TrEMBL
PhenoGen Pttg1ip2 PhenoGen
RatGTEx ENSRNOG00000051419 RatGTEx
UniProt A0A0G2K8W5 ENTREZGENE, UniProtKB/TrEMBL
  A6K263 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-10 Pttg1ip2  PTTG1IP family member 2  LOC103692048  uncharacterized LOC103692048  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103692048  uncharacterized LOC103692048      Symbol and Name status set to provisional 70820 PROVISIONAL