Fam3b (FAM3 metabolism regulating signaling molecule B)

Gene: Fam3b (FAM3 metabolism regulating signaling molecule B) Chinchilla lanigera

Analyze

Symbol:

Fam3b

Name:

FAM3 metabolism regulating signaling molecule B

RGD ID:

9067808

Description:

INVOLVED IN insulin secretion (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

family with sequence similarity 3 member B; family with sequence similarity 3, member B

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	40,914,239 - 40,932,177 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	40,914,408 - 40,939,850 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

insulin secretion (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Fam3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	40,914,239 - 40,932,177 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	40,914,408 - 40,939,850 (-)	NCBI	ChiLan1.0	ChiLan1.0

FAM3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	41,304,242 - 41,357,727 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	41,304,212 - 41,357,727 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	42,688,728 - 42,729,654 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	41,610,531 - 41,651,524 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	21	27,886,894 - 27,927,901 (+)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	28,157,559 - 28,198,557 (+)	NCBI		HuRef
CHM1_1	21	42,249,456 - 42,290,457 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	39,692,606 - 39,746,338 (+)	NCBI		T2T-CHM13v2.0

Fam3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	97,272,165 - 97,306,136 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	97,272,165 - 97,316,016 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	97,470,965 - 97,504,936 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	97,470,965 - 97,514,816 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	97,692,693 - 97,726,543 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	97,575,996 - 97,659,852 (-)	NCBI		MGSCv36	mm8
Celera	16	98,531,405 - 98,565,114 (-)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	57.47	NCBI

Fam3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	50,300,926 - 50,333,296 (-)	NCBI		GRCr8
mRatBN7.2	11	36,831,532 - 36,863,902 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	36,831,532 - 36,869,713 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	45,480,008 - 45,512,453 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	38,151,386 - 38,183,828 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	37,311,313 - 37,343,761 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	37,922,308 - 37,993,279 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	37,922,292 - 37,993,207 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	41,429,763 - 41,503,454 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	37,470,404 - 37,505,705 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	37,528,141 - 37,558,745 (-)	NCBI
Celera	11	36,718,301 - 36,749,239 (-)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

FAM3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	37,396,847 - 37,438,869 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	32,251,107 - 32,293,169 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	27,650,185 - 27,692,249 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	40,979,149 - 41,020,089 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	40,979,149 - 41,020,089 (+)	Ensembl	panpan1.1		panPan2

FAM3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	35,805,981 - 35,844,258 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	35,806,217 - 35,844,263 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	34,961,227 - 34,999,135 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	35,323,709 - 35,361,728 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	35,323,758 - 35,361,733 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	35,219,538 - 35,257,553 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	35,197,593 - 35,235,594 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	35,691,726 - 35,729,740 (+)	NCBI		UU_Cfam_GSD_1.0

Fam3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	35,149,735 - 35,178,093 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	2,289,687 - 2,318,977 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	2,289,795 - 2,317,616 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FAM3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	204,752,196 - 204,796,777 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	204,746,338 - 204,796,792 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	215,061,989 - 215,072,431 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FAM3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	85,211,126 - 85,277,034 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	85,223,553 - 85,277,839 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	13,075,832 - 13,129,760 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fam3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	28,639,087 - 28,659,627 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	28,638,914 - 28,658,930 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005375853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013506145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013506148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01007852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01327668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000008452 ⟹ ENSCLAP00000008325

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955407	40,914,239 - 40,932,177 (-)	Ensembl

RefSeq Acc Id:

XM_005375853 ⟹ XP_005375910

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955407	40,914,408 - 40,939,850 (-)	NCBI

Sequence:

show sequence

GGCGGAGGAGGGGCACGGCGGGACAGGATGGAGTGGGACACGCGCGTCGGGGTTCGCGGAGCCC
GGAGCTGCGGAGGCGGCGCCTTCAAGGCCTTGTTCCTGGTCTTTGCCGCCCTCTGCGCCTGGTA
CTCTGGGTATCTGGTGGTGGAGCTTATTCCCGACGTGCATCTGACCAATGCCATCTACAGCATA
CGGAGCATCGGGGAGAAGCCTGTCCTCAAAGCCCCACCCCCCAGAAGGCAGAAATGCGACCACT
GGACCCCATGTCCTCCCAACACCTACGCCTACCGGCTACTGAGCGGCGGGGGCAGAGACAAGCA
CGCCAAGATCTGCTTTGAGGACGAGCTGCTCATGGGCGAGAAGATGGGGAACATCCAGCGAGGG
ATAAACATCGCCGTCGTCAGCTATGTAACTGGGAAGGTCACGGCCACACGATCTTTTGACATGT
ACGAAGGCGATAACTCCACACCCATGACCCAGTTCATTCAGAGCGCACCCGCGAAGTCCCTTCT
GCTCATGGTGACCCACGACGACGGGAGCACCAGACTGAAGGCTGACGCCAAGAACGCCATCGAG
GCGCTGGGAAGCAGAGAGATCCGGAACATGAAGTTCAGGTCCAGCTGGGTGTTCCTGGCGGCCA
CCGGCTTCGAGCTGCCCGCGGGACTCCCGAGGGAGAAGATCAACCACTCCGACAGTTCCAAGAA
CAGGTACTCCGGCTGGCCCGCAGAGATCCAGATCGAGGGCTGCATTCCCAGGGAGCCAAGCTAG
CGCTGCGCGGCCCTCAATAAATGTGTTTGTGTGGACAAGGCA

hide sequence

RefSeq Acc Id:

XM_013506145 ⟹ XP_013361599

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955407	40,914,408 - 40,939,850 (-)	NCBI

Sequence:

show sequence

GGCGGAGGAGGGGCACGGCGGGACAGGATGGAGTGGGACACGCGCGTCGGGGTTCGCGGAGCCC
GGAGCTGCGGAGGCGGCGCCTTCAAGGCCTTGTTCCTGGTCTTTGCCGCCCTCTGCGCCTGGTA
CTCTGGGTATCTGGTGGTGGAGCTTATTCCCGACGTGCATCTGACCAATGCCATCTACAGCATA
CGGAGCATCGGGGAGAAGCCTGTCCTCAAAGCCCCACCCCCCAGAAGGCAGAAATGCGACCACT
GGACCCCATGTCCTCCCAACACCTACGCCTACCGGCTACTGAGCGGCGGGGGCAGAGACAAGCA
CGCCAAGATCTGCTTTGAGGACGAGCTGCTCATGGGCGAGAAGATGGGGAACATCCAGCGAGGG
ATAAACATCGCCGTCGTCAGCTATGTAACTGGGAAGGTCACGGCCACACGATCTTTTGACATGT
ACGAAGGCGGTGACCCTGCAGATAACTCCACACCCATGACCCAGTTCATTCAGAGCGCACCCGC
GAAGTCCCTTCTGCTCATGGTGACCCACGACGACGGGAGCACCAGACTGAAGGCTGACGCCAAG
AACGCCATCGAGGCGCTGGGAAGCAGAGAGATCCGGAACATGAAGTTCAGGTCCAGCTGGGTGT
TCCTGGCGGCCACCGGCTTCGAGCTGCCCGCGGGACTCCCGAGGGAGAAGATCAACCACTCCGA
CAGTTCCAAGAACAGGTACTCCGGCTGGCCCGCAGAGATCCAGATCGAGGGCTGCATTCCCAGG
GAGCCAAGCTAGCGCTGCGCGGCCCTCAATAAATGTGTTTGTGTGGACAAGGCA

hide sequence

RefSeq Acc Id:

XM_013506148 ⟹ XP_013361602

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955407	40,914,408 - 40,932,100 (-)	NCBI

Sequence:

show sequence

CCCCTCCCGAGTCTCCTCCCTAAGCCTCAGTGAGGCTGAGGCTCTCACAGGTGCTGGCGGGGGT
GGTGGGGAGCAGCGCCAGGAAGATGCGCCCCGGGGCTGCAGGCGCCTTCAAGGCCTTGTTCCTG
GTCTTTGCCGCCCTCTGCGCCTGGTACTCTGGGTATCTGGTGGTGGAGCTTATTCCCGACGTGC
ATCTGACCAATGCCATCTACAGCATACGGAGCATCGGGGAGAAGCCTGTCCTCAAAGCCCCACC
CCCCAGAAGGCAGAAATGCGACCACTGGACCCCATGTCCTCCCAACACCTACGCCTACCGGCTA
CTGAGCGGCGGGGGCAGAGACAAGCACGCCAAGATCTGCTTTGAGGACGAGCTGCTCATGGGCG
AGAAGATGGGGAACATCCAGCGAGGGATAAACATCGCCGTCGTCAGCTATGTAACTGGGAAGGT
CACGGCCACACGATCTTTTGACATGTACGAAGGCGGTGACCCTGCAGATAACTCCACACCCATG
ACCCAGTTCATTCAGAGCGCACCCGCGAAGTCCCTTCTGCTCATGGTGACCCACGACGACGGGA
GCACCAGACTGAAGGCTGACGCCAAGAACGCCATCGAGGCGCTGGGAAGCAGAGAGATCCGGAA
CATGAAGTTCAGGTCCAGCTGGGTGTTCCTGGCGGCCACCGGCTTCGAGCTGCCCGCGGGACTC
CCGAGGGAGAAGATCAACCACTCCGACAGTTCCAAGAACAGGTACTCCGGCTGGCCCGCAGAGA
TCCAGATCGAGGGCTGCATTCCCAGGGAGCCAAGCTAGCGCTGCGCGGCCCTCAATAAATGTGT
TTGTGTGGACAAGGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005375910	(Get FASTA)	NCBI Sequence Viewer
	XP_013361599	(Get FASTA)	NCBI Sequence Viewer
	XP_013361602	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000008325
	ENSCLAP00000008325.1

RefSeq Acc Id:	XP_005375910 ⟸ XM_005375853
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2V061 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEWDTRVGVRGARSCGGGAFKALFLVFAALCAWYSGYLVVELIPDVHLTNAIYSIRSIGEKPVL KAPPPRRQKCDHWTPCPPNTYAYRLLSGGGRDKHAKICFEDELLMGEKMGNIQRGINIAVVSYV TGKVTATRSFDMYEGDNSTPMTQFIQSAPAKSLLLMVTHDDGSTRLKADAKNAIEALGSREIRN MKFRSSWVFLAATGFELPAGLPREKINHSDSSKNRYSGWPAEIQIEGCIPREPS hide sequence

RefSeq Acc Id:	XP_013361599 ⟸ XM_013506145
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2V061 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEWDTRVGVRGARSCGGGAFKALFLVFAALCAWYSGYLVVELIPDVHLTNAIYSIRSIGEKPVL KAPPPRRQKCDHWTPCPPNTYAYRLLSGGGRDKHAKICFEDELLMGEKMGNIQRGINIAVVSYV TGKVTATRSFDMYEGGDPADNSTPMTQFIQSAPAKSLLLMVTHDDGSTRLKADAKNAIEALGSR EIRNMKFRSSWVFLAATGFELPAGLPREKINHSDSSKNRYSGWPAEIQIEGCIPREPS hide sequence

RefSeq Acc Id:	XP_013361602 ⟸ XM_013506148
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C2V061 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPGAAGAFKALFLVFAALCAWYSGYLVVELIPDVHLTNAIYSIRSIGEKPVLKAPPPRRQKCD HWTPCPPNTYAYRLLSGGGRDKHAKICFEDELLMGEKMGNIQRGINIAVVSYVTGKVTATRSFD MYEGGDPADNSTPMTQFIQSAPAKSLLLMVTHDDGSTRLKADAKNAIEALGSREIRNMKFRSSW VFLAATGFELPAGLPREKINHSDSSKNRYSGWPAEIQIEGCIPREPS hide sequence

RefSeq Acc Id:

ENSCLAP00000008325 ⟸ ENSCLAT00000008452

Protein Domains

ILEI/PANDER

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005832	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000008452	ENTREZGENE
	ENSCLAT00000008452.1	UniProtKB/TrEMBL
InterPro	FAM3	UniProtKB/TrEMBL
	ILEI/PANDER_dom	UniProtKB/TrEMBL
NCBI Gene	Fam3b	ENTREZGENE
PANTHER	PTHR14592	UniProtKB/TrEMBL
	PTHR14592:SF2	UniProtKB/TrEMBL
Pfam	ILEI	UniProtKB/TrEMBL
UniProt	A0A8C2V061	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-24	Fam3b	FAM3 metabolism regulating signaling molecule B	Fam3b	family with sequence similarity 3 member B	Symbol and/or name change	5135510	APPROVED
2016-08-16	Fam3b	family with sequence similarity 3 member B		family with sequence similarity 3, member B	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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