Drd5 (dopamine receptor D5) - Rat Genome Database

Name: Drd5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Drd5 (dopamine receptor D5) Chinchilla lanigera

Analyze

Symbol:

Drd5

Name:

dopamine receptor D5

RGD ID:

9067242

Description:

ENCODES a protein that exhibits dopamine binding (ortholog); dopamine neurotransmitter receptor activity (ortholog); dopamine neurotransmitter receptor activity, coupled via Gs (ortholog); INVOLVED IN adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); associative learning (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D1 family of receptors; G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH Alzheimer's disease (ortholog); attention deficit hyperactivity disorder (ortholog); Benign Essential Blepharospasm (ortholog); FOUND IN axon (ortholog); brush border membrane (ortholog); ciliary membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

D(1B) dopamine receptor

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DRD5 (dopamine receptor D5)	NCBI	Ortholog
Mus musculus (house mouse):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DRD5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Drd5 (dopamine receptor D5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955514	5,450,495 - 5,452,282 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

attention deficit hyperactivity disorder (ISO)

Benign Essential Blepharospasm (ISO)

bipolar disorder (ISO)

blepharospasm (ISO)

cervical dystonia (ISO)

depressive disorder (ISO)

genetic disease (ISO)

Huntington's disease (ISO)

hypertension (ISO)

Parkinson's disease (ISO)

pervasive developmental disorder (ISO)

psychotic disorder (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating dopamine receptor signaling pathway (ISO)

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

associative learning (ISO)

cellular response to catecholamine stimulus (ISO)

dopamine receptor signaling pathway (ISO)

long-term synaptic depression (ISO)

mating behavior (ISO)

negative regulation of blood pressure (ISO)

negative regulation of cell migration (ISO)

negative regulation of protein kinase activity (ISO)

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure (ISO)

reactive oxygen species metabolic process (ISO)

regulation of female receptivity (ISO)

regulation of postsynaptic membrane neurotransmitter receptor levels (ISO)

regulation of systemic arterial blood pressure by vasopressin (ISO)

response to amphetamine (ISO)

response to cocaine (ISO)

sensitization (ISO)

transmission of nerve impulse (ISO)

visual learning (ISO)

wound healing (ISO)

Cellular Component

axon (ISO)

brush border membrane (ISO)

ciliary membrane (ISO)

cilium (ISO)

dendrite (ISO)

dendritic spine (ISO)

glutamatergic synapse (ISO)

neuronal cell body (ISO)

non-motile cilium (ISO)

plasma membrane (ISO)

postsynaptic density membrane (ISO)

Molecular Function

dopamine binding (ISO)

dopamine neurotransmitter receptor activity (ISO)

dopamine neurotransmitter receptor activity, coupled via Gs (ISO)

G-protein alpha-subunit binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

dopamine signaling pathway (ISO)

dopamine signaling pathway via D1 family of receptors (ISO)

G protein mediated signaling pathway via Galphaq family (ISO)

G protein mediated signaling pathway via Galphas family (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Drd5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955514	5,450,495 - 5,452,282 (+)	NCBI	ChiLan1.0	ChiLan1.0

DRD5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	9,781,634 - 9,784,009 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	9,781,634 - 9,784,009 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	9,783,258 - 9,785,633 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	9,392,701 - 9,394,731 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	9,459,871 - 9,461,901	NCBI
Celera	4	10,266,117 - 10,268,492 (+)	NCBI		Celera
Cytogenetic Map	4	p16.1	NCBI
HuRef	4	9,117,663 - 9,120,038 (+)	NCBI		HuRef
CHM1_1	4	9,781,174 - 9,783,549 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	9,781,407 - 9,783,782 (+)	NCBI		T2T-CHM13v2.0

Drd5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	38,476,742 - 38,479,868 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	38,476,710 - 38,479,861 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	38,319,509 - 38,322,523 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	38,319,367 - 38,322,518 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	38,710,748 - 38,713,549 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	38,607,758 - 38,610,559 (+)	NCBI		MGSCv36	mm8
Celera	5	35,773,146 - 35,775,947 (+)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	20.4	NCBI

Drd5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	76,700,244 - 76,703,344 (-)	NCBI		GRCr8
mRatBN7.2	14	72,487,950 - 72,491,050 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	72,489,347 - 72,490,774 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	76,931,000 - 76,932,427 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	78,171,890 - 78,173,317 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	74,611,945 - 74,613,372 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	77,220,579 - 77,222,006 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	77,220,579 - 77,222,006 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	77,202,167 - 77,203,594 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	77,768,060 - 77,769,487 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	77,770,450 - 77,771,878 (-)	NCBI
Celera	14	71,440,495 - 71,441,922 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

DRD5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	10,026,932 - 10,030,293 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	10,235,569 - 10,237,977 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	4,189,536 - 4,193,144 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	9,508,711 - 9,511,072 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	9,509,094 - 9,510,527 (+)	Ensembl	panpan1.1		panPan2

DRD5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	69,621,187 - 69,623,522 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	69,621,734 - 69,623,893 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	72,173,244 - 72,175,212 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	70,378,089 - 70,380,057 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	70,378,633 - 70,380,057 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	69,652,224 - 69,654,192 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	69,817,637 - 69,819,605 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	70,198,942 - 70,200,910 (-)	NCBI		UU_Cfam_GSD_1.0

Drd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	63,158,693 - 63,162,200 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	16,861,773 - 16,863,215 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	16,860,222 - 16,863,505 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DRD5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	6,180,221 - 6,181,636 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	6,180,221 - 6,182,575 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	5,694,230 - 5,696,186 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DRD5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	40,267,681 - 40,270,061 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	40,268,235 - 40,269,671 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	87,064,155 - 87,066,433 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Drd5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624755	21,358,586 - 21,361,410 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005408842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01067155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005408842 ⟹ XP_005408899

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955514	5,450,495 - 5,452,282 (+)	NCBI

Sequence:

show sequence

GCTCGATGGGGCCTCCCGAGGGGCGCAGGGCTGAAGTTGGTTCCGCGCGCATCTTGCCTCTGCC
TCTGAGCCCGACATGCTGCCGCCTGGGCGCAATGGCACCGCACATCCCCTGTGGTTCGGGTTTC
GGGCTCGGCTGGCCAAGGAGGGCGCCGCGGGGGGCTCGGCGGGGGCGGCGCCGCTGGGGCCAGC
GCAGGTGGTCACCGCCGGCCTCCTGACTCTGCTCATCGTGTGGACGCTGCTGGGCAACGTGCTG
GTGTGCGCGGCCATCGTGCGCAGCCGCCACCTGCGCGCCAAGACGACCAACGTCTTCATCGTGT
CCCTGGCCTTGTCGGACCTCTTCGTGGCGCTGCTCGTCATGCCCTGGAAGGCGGTGACGGAGGT
GGCCGGTTACTGGCCCTTTGGCGCATTCTGCGACATCTGGGTGGCCTTTGACATCATGTGTTCT
ACCGCCTCCATCCTGAACCTGTGCGTCATCAGCGTGGACCGCTACTGGGCCATCTCCAGACCCT
TCCGCTACCAGCGCAAGATGACCCAGCGCGTGGCCTTGGTCATGGTGGGCCTGGCCTGGGCCCT
GTCCATCCTCATCTCCTTCATTCCAGTCCAGCTGAACTGGCACCGGGGAGCGGTGGGCTCCGAG
GCCAGAGTGGACCTTCACTCCAACCTGGACAACGGCACGGCCTGGGAGGAGCCCGGGGAGCCCG
AGCGGAGGGCAGCGGCCTGTGACTCCAGCCTGAACCGAGCGTACGCCATCTCCTCCTCACTCAT
CAGCTTCTACATCCCTGTGGCCATCATGATCGCGACCTACACGCGCATCTACCGCATCGCGCAG
GTGCAGATTCGCAGGATCTCGTCGCTGGAGAGGGCCGCCGAGCATGTGCAGAGCTGCCGCAGCC
ACGTGGGCTGCGAGCCCGACGCCAGCCTGCGCGTGTCCATCAGGAAGGAGGCCAAGGTGCTCAA
GACGCTGTCGGTGATTATGGGGGTCTTCGTGTGCTGCTGGCTGCCTTTCTTCATCCTTAACTGC
ATGGTTCCGTTCTGCCACGGAGACCCCGAGGACCCGAGGGCCGGCTTCCCTTGCGTCAGCGAGA
CCACTTTTGACGTCTTTGTCTGGTTCGGCTGGACCAACTCCTCGCTCAACCCCGTCATCTACGC
TTTTAACGCTGACTTCCGGAAGGTGTTTGCCCAACTGCTGGGGTGCAGCCATCTCTGCTTGCGC
ACCCCAGTGGAGACCGTGAACATCAGCAACGAGCTCATCTCCTACAACCAGGACACTGTCTTCC
ACAAGGAGGTCGCGGCCACCTATGTCCACACGATCCCCAACGCTGTGGCCCCCAGGGACAGGGA
GCTGGAGGACGAGGAGGGGGAGGAGGGCCCTTTCGATCGTATGTCTCAGATCTGCCAGACGTCC
CCAGACGGCGACCCTGCAGCTGAATCTGTCTGGGAGCTGGACTGTGAGGGGGAAATTTCATTAG
GCAAAATAACTCCTCTTACCCCAAATGGATTTCATTAAACCACGTAAGAAAAGCCCTGTGGATC
TGCATAAGCGCATACACATTTACAAGCCCACGCCCCCATCCAGCGGCTGATCAGTTGATCAATG
TTTCTCTGTCTCTGTGAATTCGCTCATGTGCTGGGAGTCCTCACGCACCCTGTAGCTTCCTAGG
TGAAAACATAGGCAGAAGCAGTTAGAATCAACTTGCCTATTCCCTGTTTTCCAGCCTGGCAGAG
ATGACCAGGGGCCTGTTAGAGAAGAGAAAGTGGTGCTTGGCCCTTAAAAATTACACTGTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005408899	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005408899 ⟸ XM_005408842

- Sequence:

show sequence

MLPPGRNGTAHPLWFGFRARLAKEGAAGGSAGAAPLGPAQVVTAGLLTLLIVWTLLGNVLVCAA
IVRSRHLRAKTTNVFIVSLALSDLFVALLVMPWKAVTEVAGYWPFGAFCDIWVAFDIMCSTASI
LNLCVISVDRYWAISRPFRYQRKMTQRVALVMVGLAWALSILISFIPVQLNWHRGAVGSEARVD
LHSNLDNGTAWEEPGEPERRAAACDSSLNRAYAISSSLISFYIPVAIMIATYTRIYRIAQVQIR
RISSLERAAEHVQSCRSHVGCEPDASLRVSIRKEAKVLKTLSVIMGVFVCCWLPFFILNCMVPF
CHGDPEDPRAGFPCVSETTFDVFVWFGWTNSSLNPVIYAFNADFRKVFAQLLGCSHLCLRTPVE
TVNISNELISYNQDTVFHKEVAATYVHTIPNAVAPRDRELEDEEGEEGPFDRMSQICQTSPDGD
PAAESVWELDCEGEISLGKITPLTPNGFH

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Drd5	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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