Tlr3 (toll like receptor 3) - Rat Genome Database

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Gene: Tlr3 (toll like receptor 3) Chinchilla lanigera
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Symbol: Tlr3
Name: toll like receptor 3
RGD ID: 9064773
Description: ENCODES a protein that exhibits double-stranded RNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to exogenous dsRNA (ortholog); cellular response to interferon-beta (ortholog); cellular response to interferon-gamma (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); intracellular anatomical structure (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: toll-like receptor 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,979,120 - 23,001,467 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to exogenous dsRNA  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to virus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
defense response  (ISO)
defense response to virus  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
I-kappaB phosphorylation  (ISO)
JNK cascade  (ISO)
male gonad development  (ISO)
MAPK cascade  (ISO)
microglial cell activation  (ISO)
necroptotic signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
positive regulation of type III interferon production  (ISO)
regulation of dendritic cell cytokine production  (ISO)
response to dsRNA  (ISO)
response to exogenous dsRNA  (ISO)
response to virus  (ISO)
toll-like receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Tlr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,979,120 - 23,001,467 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBIChiLan1.0ChiLan1.0
TLR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4186,069,155 - 186,088,073 (+)EnsemblGRCh38hg38GRCh38
GRCh384186,069,156 - 186,088,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374186,990,310 - 187,009,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,227,303 - 187,243,246 (+)NCBINCBI36hg18NCBI36
Build 344187,365,457 - 187,381,399NCBI
Celera4184,312,848 - 184,328,791 (+)NCBI
Cytogenetic Map4q35.1NCBI
HuRef4182,742,451 - 182,758,393 (+)NCBIHuRef
CHM1_14186,966,756 - 186,982,686 (+)NCBICHM1_1
Tlr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,848,702 - 45,864,112 (-)NCBIGRCm39mm39
GRCm39 Ensembl845,848,702 - 45,864,117 (-)Ensembl
GRCm38845,395,665 - 45,411,075 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,395,665 - 45,411,080 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,481,019 - 46,495,893 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,894,482 - 46,909,356 (-)NCBImm8
Celera848,083,156 - 48,098,074 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
Tlr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21646,821,980 - 46,837,900 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1646,822,039 - 46,836,545 (+)Ensembl
Rnor_6.01650,016,466 - 50,031,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,016,857 - 50,031,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,739,814 - 49,753,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,112,910 - 50,126,371 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11650,112,984 - 50,126,440 (+)NCBI
Celera1644,813,138 - 44,826,566 (+)NCBICelera
Cytogenetic Map16q11NCBI
TLR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14190,446,487 - 190,462,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,446,487 - 190,462,728 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04178,238,352 - 178,256,264 (+)NCBIMhudiblu_PPA_v0panPan3
TLR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,617,012 - 44,633,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,550,846 - 44,653,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,103,720 - 45,132,454 (-)NCBI
ROS_Cfam_1.01646,830,974 - 46,859,705 (-)NCBI
UMICH_Zoey_3.11644,798,956 - 44,827,679 (-)NCBI
UNSW_CanFamBas_1.01645,411,963 - 45,440,690 (-)NCBI
UU_Cfam_GSD_1.01645,543,452 - 45,571,950 (-)NCBI
Tlr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,721,792 - 34,740,517 (+)NCBI
SpeTri2.0NW_0049365543,370,766 - 3,388,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,966,040 - 47,058,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,966,262 - 46,977,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,839,254 - 53,852,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17131,991,068 - 132,014,366 (+)NCBI
ChlSab1.1 Ensembl7131,991,029 - 132,016,232 (+)Ensembl
Vero_WHO_p1.0NW_023666037112,309,987 - 112,333,459 (+)NCBI
Tlr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476916,925,969 - 16,945,250 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017829   ⟹   ENSCLAP00000017655
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540322,979,120 - 23,001,467 (-)Ensembl
RefSeq Acc Id: XM_005373437   ⟹   XP_005373494
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,986,766 - 23,001,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005373438   ⟹   XP_005373495
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,986,766 - 23,001,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005373439   ⟹   XP_005373496
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005373440   ⟹   XP_005373497
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013512872   ⟹   XP_013368326
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005373497   ⟸   XM_005373440
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005373496   ⟸   XM_005373439
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005373495   ⟸   XM_005373438
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005373494   ⟸   XM_005373437
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013368326   ⟸   XM_013512872
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000017655   ⟸   ENSCLAT00000017829


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012107 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000017655 ENTREZGENE
Ensembl Transcript ENSCLAT00000017829 ENTREZGENE
NCBI Gene Tlr3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tlr3  toll like receptor 3    toll-like receptor 3  Symbol and/or name change 5135510 APPROVED