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Gene: Ndufs3 (NADH:ubiquinone oxidoreductase core subunit S3) Chinchilla lanigera

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Symbol:

Ndufs3

Name:

NADH:ubiquinone oxidoreductase core subunit S3

RGD ID:

9057280

Description:

ENCODES a protein that exhibits NADH dehydrogenase (ubiquinone) activity (ortholog); NADH dehydrogenase activity (ortholog); INVOLVED IN mitochondrial electron transport, NADH to ubiquinone (ortholog); mitochondrial respiratory chain complex I assembly (ortholog); reactive oxygen species metabolic process (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); Cardiomegaly (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	709,784 - 717,926 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	713,370 - 717,926 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Breast Neoplasms (ISO)

Cardiomegaly (ISO)

Chemical and Drug Induced Liver Injury (ISO)

congenital disorder of glycosylation type IIc (ISO)

Diabetic Nephropathies (ISO)

Experimental Diabetes Mellitus (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Leigh disease (ISO)

mitochondrial complex I deficiency (ISO)

nuclear type mitochondrial complex I deficiency 1 (ISO)

nuclear type mitochondrial complex I deficiency 8 (ISO)

optic atrophy (ISO)

Parkinsonism (ISO)

Subacute Necrotizing Encephalopathy of Leigh, Infantile (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial electron transport, NADH to ubiquinone (ISO)

mitochondrial respiratory chain complex I assembly (ISO)

reactive oxygen species metabolic process (ISO)

substantia nigra development (ISO)

Cellular Component

mitochondrial inner membrane (ISO)

mitochondrial membrane (ISO)

mitochondrion (ISO)

nuclear body (ISO)

respiratory chain complex I (ISO)

Molecular Function

NADH dehydrogenase (ubiquinone) activity (ISO)

NADH dehydrogenase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

doxorubicin pharmacokinetics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Ndufs3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	709,784 - 717,926 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	713,370 - 717,926 (-)	NCBI	ChiLan1.0	ChiLan1.0

NDUFS3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	47,579,074 - 47,584,562 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	47,565,336 - 47,584,562 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	47,600,626 - 47,606,114 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	47,557,208 - 47,562,690 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	47,557,207 - 47,562,689	NCBI
Celera	11	47,743,293 - 47,748,843 (+)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	47,301,639 - 47,307,200 (+)	NCBI		HuRef
CHM1_1	11	47,599,803 - 47,605,356 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	47,739,496 - 47,744,966 (+)	NCBI		T2T-CHM13v2.0

Ndufs3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	90,724,971 - 90,735,065 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	90,724,978 - 90,735,171 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	90,894,627 - 90,904,721 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	90,894,634 - 90,904,827 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	90,734,793 - 90,744,878 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	90,695,475 - 90,705,560 (-)	NCBI		MGSCv36	mm8
Celera	2	92,279,671 - 92,289,201 (-)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.44	NCBI

Ndufs3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,332,477 - 97,339,654 (-)	NCBI		GRCr8
mRatBN7.2	3	76,876,646 - 76,883,824 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	76,876,646 - 76,883,824 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,354,354 - 80,361,560 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	88,952,835 - 88,960,041 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	86,804,226 - 86,811,400 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,721,686 - 79,728,863 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,721,694 - 79,728,879 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,430,806 - 86,437,983 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,256,383 - 75,263,560 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,152,762 - 75,159,826 (-)	NCBI
Celera	3	76,085,667 - 76,092,843 (-)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

NDUFS3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	49,776,948 - 49,788,940 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	49,803,175 - 49,808,697 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	47,528,680 - 47,534,206 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	48,078,332 - 48,083,863 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	48,078,332 - 48,083,863 (+)	Ensembl	panpan1.1		panPan2

NDUFS3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,069,402 - 42,075,843 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,069,398 - 42,076,921 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	40,800,727 - 40,807,169 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	42,725,265 - 42,731,706 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	42,725,271 - 42,731,666 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,212,502 - 42,219,616 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	41,766,818 - 41,773,261 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,496,862 - 42,503,304 (-)	NCBI		UU_Cfam_GSD_1.0

Ndufs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	19,556,138 - 19,563,014 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	1,664,293 - 1,674,670 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	1,667,780 - 1,674,670 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NDUFS3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	15,031,149 - 15,036,880 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	15,031,147 - 15,036,880 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	16,207,693 - 16,213,425 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NDUFS3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	17,735,040 - 17,740,508 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	17,733,645 - 17,745,677 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	115,027,358 - 115,033,159 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ndufs3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,237,261 - 1,244,031 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	1,238,953 - 1,243,945 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005383959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01022432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01030985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000021930 ⟹ ENSCLAP00000021727

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955422	709,784 - 717,926 (-)	Ensembl

RefSeq Acc Id:

XM_005383959 ⟹ XP_005384016

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955422	713,370 - 717,926 (-)	NCBI

Sequence:

show sequence

GCCGGGTCTGCATCCGGGGAACATGGCGGCCGCCGCGGCCAGGGTCTGGTGGCGAGGGCTCGCG
GGGGCCAGAGCGGTGGCCGGCGGGGCTGGGCGACGCTCGGCGCGGCTGCAGTGCGCGCGGCGGG
AGAGCGCGGCGGCCGACTCGCGCCCCACTGTTAGGCCACAGGATGCAGTGACCCACAAGCAGCT
CTCAGCTTTTGGGGAGTATGTGGCTGAAATCCTGCCCAAGTATGTGCAGCAAGTTCAGGTGACC
TGCTTCAATGAGCTAGAGGTCTGTATCCATCCCGACGGGGTCATCCCAGTGCTCACCTTCCTCA
GGGATCACTCCAATGCACAGTTCAAATCCTTGGCTGACTTGACGGCAGTGGACATCCCAACTCG
GCAGAACCGTTTTGAGATTGTCTACAACCTGCTGTCCCTGCGCTTCAACTCCCGGATCCGTGTG
AAGACCTACACGGATGAGCTGACACCCATTGAGTCCTCAGTCTCAGTGTTCAAGGCGTCCATCT
GGTATGAGAGGGAGGTCTGGGACATGTTCGGAGTCTTCTTTACTAACCACCCTGACCTGAGGCG
GATCCTGACAGATTACGGCTTTGAGGGACATCCCTTCCGGAAGGACTTCCCCCTGTCCGGCTAT
GTTGAGTTGCGCTATGACGATGAGGTGAAGCGTGTTGTGGCTGAGCCAGTGGAGCTGGCCCAGG
AGTTCCGCAAGTTCGACCTGAACAGCCCGTGGGAGACTTTCCCTGCCTACCGCCAGCCCCCCGA
GAGCCCCAAGCTCCAAGCCGGAGACCAGAAGGCGGAAGCCAAGTAGCTTGCAGGAGGTGTGTGG
ATCCTGGAGAGCACCGTGCCTGCCTGCGTGGGACAAAGTCTGTAAATAAATTCCTGCCTGGACT
CAC

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Protein Sequences


Protein RefSeqs	XP_005384016	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000021727
	ENSCLAP00000021727.1

RefSeq Acc Id:

XP_005384016 ⟸ XM_005383959

- UniProtKB:

A0A8C2VWP3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAAAARVWWRGLAGARAVAGGAGRRSARLQCARRESAAADSRPTVRPQDAVTHKQLSAFGEYV
AEILPKYVQQVQVTCFNELEVCIHPDGVIPVLTFLRDHSNAQFKSLADLTAVDIPTRQNRFEIV
YNLLSLRFNSRIRVKTYTDELTPIESSVSVFKASIWYEREVWDMFGVFFTNHPDLRRILTDYGF
EGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWETFPAYRQPPESPKLQAG
DQKAEAK

hide sequence

Ensembl Acc Id:

ENSCLAP00000021727 ⟸ ENSCLAT00000021930

Protein Domains

NADH:ubiquinone oxidoreductase 30kDa subunit

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000014873	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000021930	ENTREZGENE
	ENSCLAT00000021930.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.460.80	UniProtKB/TrEMBL
InterPro	NADH_DH_suC	UniProtKB/TrEMBL
	NADH_quin_OxRdtase_su_C/D-like	UniProtKB/TrEMBL
	NADH_UbQ_OxRdtase_30kDa_su	UniProtKB/TrEMBL
	NADH_UbQ_OxRdtase_CS	UniProtKB/TrEMBL
NCBI Gene	Ndufs3	ENTREZGENE
PANTHER	NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL	UniProtKB/TrEMBL
	NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3	UniProtKB/TrEMBL
Pfam	Complex1_30kDa	UniProtKB/TrEMBL
PROSITE	COMPLEX1_30K	UniProtKB/TrEMBL
Superfamily-SCOP	SSF143243	UniProtKB/TrEMBL
UniProt	A0A8C2VWP3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Ndufs3	NADH:ubiquinone oxidoreductase core subunit S3		NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB