LOC102018844 (neutrophil elastase)

Gene: LOC102018844 (neutrophil elastase) Chinchilla lanigera

Analyze

Symbol:

LOC102018844 (Ensembl: ELANE)

Name:

neutrophil elastase

RGD ID:

9053040

Description:

ENCODES a protein that exhibits cytokine binding (ortholog); endopeptidase activity (ortholog); heparin binding (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); defense response to bacterium (ortholog); defense response to fungus (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); anthrax disease (ortholog); cerebral creatine deficiency syndrome (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Elane; elastase, neutrophil expressed

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	6,964,667 - 6,967,106 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	6,964,577 - 6,967,208 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

anthrax disease (ISO)

cerebral creatine deficiency syndrome (ISO)

Chediak-Higashi syndrome (ISO)

COVID-19 (ISO)

cyclic hematopoiesis (ISO)

disseminated intravascular coagulation (ISO)

Edema (ISO)

essential thrombocythemia (ISO)

Experimental Pancreatitis (ISO)

genetic disease (ISO)

glomerulonephritis (ISO)

Hyperoxic Lung Injury (ISO)

invasive aspergillosis (ISO)

Kidney Reperfusion Injury (ISO)

Liver Reperfusion Injury (ISO)

Lung Reperfusion Injury (ISO)

middle cerebral artery infarction (ISO)

mucositis (ISO)

neutropenia (ISO)

periodontitis (ISO)

Peutz-Jeghers syndrome (ISO)

pleurisy (ISO)

polycythemia vera (ISO)

pulmonary emphysema (ISO)

pulmonary fibrosis (ISO)

Pulmonary Hemorrhage (ISO)

Sepsis (ISO)

severe congenital neutropenia (ISO)

severe congenital neutropenia 1 (ISO)

Skeletal Muscle Reperfusion Injury (ISO)

Spinal Cord Compression (ISO)

suppurative periapical periodontitis (ISO)

toxic shock syndrome (ISO)

transient cerebral ischemia (ISO)

Urinary Bladder Reperfusion Injury (ISO)

Ventilator-Induced Lung Injury (ISO)

X-linked severe congenital neutropenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute inflammatory response to antigenic stimulus (ISO)

defense response to bacterium (ISO)

defense response to fungus (ISO)

leukocyte migration (ISO)

leukocyte migration involved in inflammatory response (ISO)

negative regulation of chemokine production (ISO)

negative regulation of interleukin-8 production (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

neutrophil-mediated killing of fungus (ISO)

phagocytosis (ISO)

positive regulation of immune response (ISO)

positive regulation of interleukin-8 production (ISO)

positive regulation of leukocyte tethering or rolling (ISO)

positive regulation of smooth muscle cell proliferation (ISO)

proteolysis (ISO)

response to lipopolysaccharide (ISO)

response to UV (ISO)

response to yeast (ISO)

Cellular Component

cell surface (ISO)

cytoplasm (ISO)

extracellular space (ISO)

secretory granule (ISO)

transcription repressor complex (ISO)

Molecular Function

cytokine binding (ISO)

endopeptidase activity (ISO)

heparin binding (ISO)

peptidase activity (ISO)

protease binding (ISO)

protein binding (ISO)

serine-type endopeptidase activity (ISO)

transcription corepressor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC102018844
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	6,964,667 - 6,967,106 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	6,964,577 - 6,967,208 (-)	NCBI	ChiLan1.0	ChiLan1.0

ELANE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	852,303 - 856,243 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	851,014 - 856,247 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	852,303 - 856,243 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	803,291 - 807,246 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	803,290 - 807,244	NCBI
Celera	19	777,442 - 781,374 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	621,154 - 625,109 (+)	NCBI		HuRef
CHM1_1	19	851,692 - 855,840 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	806,810 - 812,352 (+)	NCBI		T2T-CHM13v2.0

Elane
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	79,722,146 - 79,724,050 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	79,722,081 - 79,724,049 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	79,886,312 - 79,888,216 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	79,886,247 - 79,888,215 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	79,349,057 - 79,350,961 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,289,464 - 79,291,246 (+)	NCBI		MGSCv36	mm8
Celera	10	80,901,123 - 80,903,026 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Elane
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,467,877 - 10,469,725 (-)	NCBI		GRCr8
mRatBN7.2	7	9,817,251 - 9,819,174 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,817,252 - 9,819,100 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,699,238 - 12,701,086 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,574,555 - 14,576,403 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,435,754 - 12,437,602 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,638,320 - 12,640,168 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,638,322 - 12,640,232 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,808,042 - 12,809,890 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,329,642 - 11,331,490 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,329,643 - 11,331,467 (-)	NCBI
Celera	7	7,992,002 - 7,993,850 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

ELANE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	5,180,943 - 5,186,287 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	4,419,710 - 4,427,623 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	276,499 - 280,598 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	820,455 - 828,181 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ELANE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	57,789,044 - 57,790,932 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	57,788,062 - 57,790,932 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,591,060 - 57,592,948 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,531,328 - 58,533,216 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	58,531,329 - 58,533,196 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	57,586,105 - 57,588,011 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	58,065,758 - 58,067,646 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	58,268,788 - 58,270,676 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101961846
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,487,292 - 217,490,154 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	345,678 - 347,413 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	345,678 - 347,420 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ELANE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,509,344 - 77,516,027 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	77,513,769 - 77,516,118 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,480,250 - 77,485,906 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ELANE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	599,392 - 604,925 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	601,217 - 604,725 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	8,311,933 - 8,315,809 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101715199
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	7,720,020 - 7,722,842 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005406018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01062105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01239090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000012415 ⟹ ENSCLAP00000012273

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955495	6,964,667 - 6,967,106 (-)	Ensembl

RefSeq Acc Id:

XM_005406018 ⟹ XP_005406075

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955495	6,964,577 - 6,967,208 (-)	NCBI

Sequence:

show sequence

GGGGGTGCCAGCACTATGGGGCAATGCAACGGCTTCCCAGCTCCAGCTATAAGAGGGGAGGTGG
CCGGGGTGGGCCAGAGGCCCCGGAGCCCTGGCCGCACCATGACCCGAGGCCACCGAGCGCGCAG
GCCCGCCCTCACCTACGTGCTGCTGGCCCTGCTGCTGGGCAGACCCACGCTGGCCTCGGAGATC
GTGGGTGGCCGCCCAGCTCGGCCCCACTCCAGGCCCTACATGGTGTCGCTGCAGCGGCGTGGAG
GCCACTTCTGCGGCGCAACGCTGATCGCCAGGAGCTTCGTGATGTCGGCTGCGCACTGCGTGAA
CGGCCTAAACTTCCGGTCAGTGCAGGTGGTGCTGGGCGCGCATGACCTGCGGCAGCAGGAGCCC
ACCCGGCAGACTTTCAGTGTGGAGCGGATCTTTGAGAATGGCTTTGACCCTACGCTGTTGCTCA
ATGACATCGTGATTCTCCAGCTCAACGGGTCAGCCACGATCAATGCCAACGTCCAGGTGGCCCA
GCTGCCTGCTCAGGGCCGTGGCGTGCGGAGCGGGACGAGATGCCTGGCCATGGGCTGGGGCCGT
CTGGGCACGAACCGCCCGATCCCGAGTGTCCTGCAGGAGCTCAATGTGACCGTGGTGACGTCCC
AGTGTCGCCGCCGCGTCAACGTCTGCACCCTGGTGCCGCGCCGCCAGGCTGGGATCTGCTTTGG
AGACTCCGGTGGCCCCTTGGTCTGCAACGGGCTGGTCCAGGGAATCGACTCCTTCATCCGCGGG
GGCTGTGGCTCAGGCTTCTACCCAGATGCCTTTGCGCCGGTGGCGAAGTTCATAGACTGGATCA
ACTCTATCATCCACCCTGGCCAGTATGGCCCCGGCCCCACCCCAGAGTCCCCGTGAGCAGGACC
GGCTAGGAATGGGTCACCTCCGCCTCTTCACCTCGACTGCCCGTGACAGCGCTCCTCACATCTG
GCACAATAAAAGCCACTCTTCTGTACAGCGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005406075	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012273
	ENSCLAP00000012273.1

RefSeq Acc Id:

XP_005406075 ⟸ XM_005406018

- UniProtKB:

A0A8C2V9J8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGQCNGFPAPAIRGEVAGVGQRPRSPGRTMTRGHRARRPALTYVLLALLLGRPTLASEIVGGRP
ARPHSRPYMVSLQRRGGHFCGATLIARSFVMSAAHCVNGLNFRSVQVVLGAHDLRQQEPTRQTF
SVERIFENGFDPTLLLNDIVILQLNGSATINANVQVAQLPAQGRGVRSGTRCLAMGWGRLGTNR
PIPSVLQELNVTVVTSQCRRRVNVCTLVPRRQAGICFGDSGGPLVCNGLVQGIDSFIRGGCGSG
FYPDAFAPVAKFIDWINSIIHPGQYGPGPTPESP

hide sequence

RefSeq Acc Id:

ENSCLAP00000012273 ⟸ ENSCLAT00000012415

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008472	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000012415	ENTREZGENE
	ENSCLAT00000012415.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
NCBI Gene	Elane	ENTREZGENE
PANTHER	CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER	UniProtKB/TrEMBL
	NEUTROPHIL ELASTASE	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A8C2V9J8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	LOC102018844	neutrophil elastase	Elane	elastase, neutrophil expressed	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM