Tcf7l1 (transcription factor 7 like 1) - Rat Genome Database

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Gene: Tcf7l1 (transcription factor 7 like 1) Chinchilla lanigera
Analyze
Symbol: Tcf7l1
Name: transcription factor 7 like 1
RGD ID: 9045088
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN anterior/posterior axis specification, embryo (ortholog); axial mesoderm morphogenesis (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); Thyroid Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG-box)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,137,865 - 2,286,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,139,576 - 2,286,183 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Tcf7l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,137,865 - 2,286,181 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,139,576 - 2,286,183 (-)NCBIChiLan1.0ChiLan1.0
TCF7L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,133,392 - 85,310,387 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,133,392 - 85,310,387 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,360,515 - 85,537,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,214,245 - 85,391,016 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,272,391 - 85,449,162NCBI
Celera285,189,038 - 85,365,500 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,257,850 - 85,434,099 (+)NCBIHuRef
CHM1_1285,290,354 - 85,467,245 (+)NCBICHM1_1
T2T-CHM13v2.0285,135,301 - 85,312,378 (+)NCBIT2T-CHM13v2.0
Tcf7l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,603,354 - 72,766,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,603,361 - 72,766,237 (-)EnsemblGRCm39 Ensembl
GRCm38672,626,371 - 72,789,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,626,378 - 72,789,254 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,576,374 - 72,738,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,555,889 - 72,718,465 (-)NCBIMGSCv36mm8
Celera674,727,941 - 74,893,703 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Tcf7l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,238,892 - 106,404,012 (-)NCBIGRCr8
mRatBN7.24104,680,734 - 104,846,086 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,680,739 - 104,845,287 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4110,059,625 - 110,224,156 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,834,747 - 105,999,257 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,448,498 - 104,613,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,492,796 - 100,660,401 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,491,798 - 100,660,140 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,263,179 - 165,427,206 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44106,128,203 - 106,149,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14106,372,784 - 106,393,874 (-)NCBI
Celera493,833,646 - 93,998,059 (-)NCBICelera
Cytogenetic Map4q32NCBI
TCF7L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21241,072,932 - 41,249,313 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A41,075,694 - 41,252,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,186,660 - 85,363,033 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A86,739,422 - 86,914,829 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A86,739,417 - 86,913,905 (+)Ensemblpanpan1.1panPan2
TCF7L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,699,958 - 39,859,167 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,699,958 - 39,858,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,371,581 - 39,530,084 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,509,531 - 40,668,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,509,321 - 40,668,674 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,576,919 - 39,735,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,648,692 - 39,807,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01740,048,459 - 40,208,222 (-)NCBIUU_Cfam_GSD_1.0
Tcf7l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629278,895,196 - 79,009,978 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,848,464 - 1,962,650 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,848,478 - 1,962,644 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF7L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1359,438,152 - 59,458,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,435,512 - 62,533,066 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCF7L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,849,585 - 22,028,147 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604590,408,016 - 90,615,179 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf7l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,803,772 - 17,829,805 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,804,630 - 17,956,504 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000010872   ⟹   ENSCLAP00000010739
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554242,137,865 - 2,286,181 (-)Ensembl
RefSeq Acc Id: XM_013514629   ⟹   XP_013370083
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554242,139,576 - 2,286,183 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370083 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000010739
  ENSCLAP00000010739.1
Reference Protein Sequences
RefSeq Acc Id: XP_013370083   ⟸   XM_013514629
- Sequence:
RefSeq Acc Id: ENSCLAP00000010739   ⟸   ENSCLAT00000010872
Protein Domains
HMG box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000010872 ENTREZGENE
  ENSCLAT00000010872.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro CTNNB1-bd_N UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  TCF/LEF UniProtKB/TrEMBL
NCBI Gene Tcf7l1 ENTREZGENE
PANTHER PTHR10373 UniProtKB/TrEMBL
  PTHR10373:SF25 UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/TrEMBL
  HMG_box UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A8C2V656_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tcf7l1  transcription factor 7 like 1    transcription factor 7-like 1 (T-cell specific, HMG-box)  Symbol and/or name change 5135510 APPROVED