Ank2 (ankyrin 2) - Rat Genome Database

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Pathways
Gene: Ank2 (ankyrin 2) Chinchilla lanigera
Analyze
Symbol: Ank2
Name: ankyrin 2
RGD ID: 9039818
Description: ENCODES a protein that exhibits ATPase binding (ortholog); channel activator activity (ortholog); enzyme binding (ortholog); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); atrial cardiac muscle cell to AV node cell communication (ortholog); atrial septum development (ortholog); ASSOCIATED WITH aniridia (ortholog); ankyrin-B-related cardiac arrhythmia (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); FOUND IN A band (ortholog); basolateral plasma membrane (ortholog); costamere (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ankyrin 2, neuronal; ankyrin-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,624,413 - 14,076,261 (-)Ensembl
ChiLan1.0NW_00495545713,624,590 - 13,938,427 (-)NCBIChiLan1.0ChiLan1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial cardiac muscle cell action potential  (ISO)
atrial cardiac muscle cell to AV node cell communication  (ISO)
atrial septum development  (ISO)
cardiac muscle contraction  (ISO)
intracellular calcium ion homeostasis  (ISO)
intracellular protein localization  (ISO)
nervous system development  (ISO)
paranodal junction assembly  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of potassium ion import across plasma membrane  (ISO)
protein localization to cell surface  (ISO)
protein localization to endoplasmic reticulum  (ISO)
protein localization to M-band  (ISO)
protein localization to plasma membrane  (ISO)
protein localization to T-tubule  (ISO)
protein stabilization  (ISO)
regulation of atrial cardiac muscle cell action potential  (ISO)
regulation of AV node cell action potential  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of cardiac muscle cell membrane potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISO)
regulation of cation channel activity  (ISO)
regulation of heart rate  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of SA node cell action potential  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
response to methylmercury  (ISO)
SA node cell action potential  (ISO)
SA node cell to atrial cardiac muscle cell communication  (ISO)
T-tubule organization  (ISO)
ventricular cardiac muscle cell action potential  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ank2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,624,413 - 14,076,261 (-)Ensembl
ChiLan1.0NW_00495545713,624,590 - 13,938,427 (-)NCBIChiLan1.0ChiLan1.0
ANK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384112,705,622 - 113,383,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4112,818,032 - 113,384,221 (+)Ensemblhg38GRCh38
GRCh374113,626,778 - 114,304,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364114,190,319 - 114,524,337 (+)NCBIBuild 36Build 36hg18NCBI36
Celera4111,031,065 - 111,596,545 (+)NCBICelera
Cytogenetic Map4q25-q26NCBI
HuRef4109,467,190 - 110,033,212 (+)NCBIHuRef
CHM1_14113,715,710 - 114,281,305 (+)NCBICHM1_1
T2T-CHM13v2.04116,013,980 - 116,692,458 (+)NCBIT2T-CHM13v2.0
Ank2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393126,715,256 - 127,293,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3126,715,261 - 127,292,999 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383126,921,607 - 127,500,347 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3126,921,612 - 127,499,350 (-)Ensemblmm10GRCm38
MGSCv373126,624,525 - 126,701,370 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363126,913,629 - 126,990,474 (-)NCBIMGSCv36mm8
Celera3133,394,159 - 133,470,953 (-)NCBICelera
Cytogenetic Map3G2NCBI
cM Map356.07NCBI
Ank2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82218,052,555 - 218,628,414 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2218,052,555 - 218,537,259 (-)EnsemblGRCr8
mRatBN7.22215,378,028 - 215,954,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2215,379,680 - 215,862,923 (-)EnsemblmRatBN7.2
Rnor_6.02231,224,643 - 231,522,655 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2231,226,949 - 231,648,122 (-)Ensemblrn6Rnor6.0
Rnor_5.02250,573,979 - 250,869,144 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42224,182,431 - 224,501,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2207,699,846 - 207,902,141 (-)NCBICelera
RGSC_v3.12224,228,885 - 224,376,051 (-)NCBI
Cytogenetic Map2q42NCBI
ANK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23110,785,514 - 111,471,268 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14111,078,901 - 111,762,687 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04105,315,776 - 105,882,506 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14115,760,071 - 116,446,170 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4115,967,106 - 116,443,905 (+)EnsemblpanPan2panpan1.1
ANK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13232,484,196 - 33,143,295 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3232,671,281 - 33,141,036 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha328,888,883 - 9,218,786 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03233,040,789 - 33,371,120 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3232,898,398 - 33,370,466 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13233,020,952 - 33,349,123 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03232,787,755 - 33,117,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,746,226 - 7,076,960 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ank2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053017,738,663 - 8,389,184 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365633,520,193 - 4,171,362 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365633,520,195 - 4,170,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8109,306,797 - 109,912,908 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18109,306,793 - 109,661,970 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28117,345,572 - 117,559,478 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1760,487,776 - 61,174,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl760,938,523 - 61,175,519 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603739,246,221 - 39,938,996 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ank2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248386,548,159 - 7,023,945 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248386,490,434 - 7,023,945 (+)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000016480   ⟹   ENSCLAP00000016316
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,624,413 - 13,699,965 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016481   ⟹   ENSCLAP00000016317
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,626,823 - 13,811,938 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016482   ⟹   ENSCLAP00000016318
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,628,522 - 13,814,004 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016483   ⟹   ENSCLAP00000016319
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,669,882 - 13,810,846 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016484   ⟹   ENSCLAP00000016320
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,670,593 - 14,076,261 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016485   ⟹   ENSCLAP00000016321
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,739,910 - 13,873,268 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000016486   ⟹   ENSCLAP00000016322
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545713,786,763 - 13,937,524 (-)Ensembl
RefSeq Acc Id: XM_005397083   ⟹   XP_005397140
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545713,624,590 - 13,938,427 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005397085   ⟹   XP_005397142
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545713,624,590 - 13,937,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520726   ⟹   XP_013376180
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545713,624,590 - 13,839,122 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005397140   ⟸   XM_005397083
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005397142   ⟸   XM_005397085
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013376180   ⟸   XM_013520726
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCLAP00000016320   ⟸   ENSCLAT00000016484
Ensembl Acc Id: ENSCLAP00000016319   ⟸   ENSCLAT00000016483
Ensembl Acc Id: ENSCLAP00000016322   ⟸   ENSCLAT00000016486
Ensembl Acc Id: ENSCLAP00000016321   ⟸   ENSCLAT00000016485
Ensembl Acc Id: ENSCLAP00000016316   ⟸   ENSCLAT00000016480
Ensembl Acc Id: ENSCLAP00000016318   ⟸   ENSCLAT00000016482
Ensembl Acc Id: ENSCLAP00000016317   ⟸   ENSCLAT00000016481
Protein Domains
Death   ZU5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011230 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016480.1 UniProtKB/TrEMBL
  ENSCLAT00000016481 ENTREZGENE
  ENSCLAT00000016481.1 UniProtKB/TrEMBL
  ENSCLAT00000016482.1 UniProtKB/TrEMBL
  ENSCLAT00000016483.1 UniProtKB/TrEMBL
  ENSCLAT00000016484.1 UniProtKB/TrEMBL
  ENSCLAT00000016485.1 UniProtKB/TrEMBL
  ENSCLAT00000016486.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.60.220.30 UniProtKB/TrEMBL
  2.60.40.2660 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ankyrin_UPA UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  E3_Ligase-Neurotoxin UniProtKB/TrEMBL
  Multifunctional_ANK_Repeat UniProtKB/TrEMBL
  ZU5_dom UniProtKB/TrEMBL
NCBI Gene Ank2 ENTREZGENE
PANTHER ANKYRIN 2A, NEURONAL UniProtKB/TrEMBL
  ANKYRIN DOMAIN-CONTAINING UniProtKB/TrEMBL
  ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANKYRIN REPEAT-CONTAINING UniProtKB/TrEMBL
  ANKYRIN, ISOFORM B UniProtKB/TrEMBL
  ANKYRIN-3 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  UPA_2 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
UniProt A0A8C2VIS0_CHILA UniProtKB/TrEMBL
  A0A8C2VIX9_CHILA UniProtKB/TrEMBL
  A0A8C2VIY6_CHILA UniProtKB/TrEMBL
  A0A8C2VL75_CHILA UniProtKB/TrEMBL
  A0A8C2VN00_CHILA UniProtKB/TrEMBL
  A0A8C2VPD8_CHILA UniProtKB/TrEMBL
  A0A8C2VQN4_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Ank2  ankyrin 2    ankyrin 2, neuronal  Symbol and/or name change 5135510 APPROVED