Scgb1a1 (secretoglobin family 1A member 1)

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Gene: Scgb1a1 (secretoglobin family 1A member 1) Chinchilla lanigera

Analyze

Symbol:

Scgb1a1

Name:

secretoglobin family 1A member 1

RGD ID:

9037096

Description:

ENCODES a protein that exhibits polychlorinated biphenyl binding (ortholog); INVOLVED IN negative regulation of interferon-gamma production (ortholog); negative regulation of interleukin-13 production (ortholog); negative regulation of interleukin-4 production (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); allergic rhinitis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

secretoglobin, family 1A, member 1 (uteroglobin); uteroglobin

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955599	688,414 - 690,644 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Acute Lung Injury (ISO)

allergic rhinitis (ISO)

asthma (ISO)

Bronchial Hyperreactivity (ISO)

bronchiolitis obliterans (ISO)

Bronchopulmonary Dysplasia (ISO)

Carotid Artery Injuries (ISO)

glomerulonephritis (ISO)

Hyperoxia (ISO)

idiopathic interstitial pneumonia (ISO)

IgA glomerulonephritis (ISO)

Inflammation (ISO)

lung disease (ISO)

meconium aspiration syndrome (ISO)

otitis media (ISO)

pulmonary eosinophilia (ISO)

pulmonary fibrosis (ISO)

Respiration Disorders (ISO)

respiratory syncytial virus infectious disease (ISO)

Seasonal Allergic Rhinitis (ISO)

Ventilator-Induced Lung Injury (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of interferon-gamma production (ISO)

negative regulation of interleukin-13 production (ISO)

negative regulation of interleukin-4 production (ISO)

negative regulation of interleukin-5 production (ISO)

negative regulation of T cell proliferation (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

regulation of inflammatory response (ISO)

regulation of mRNA stability (ISO)

response to cytokine (ISO)

response to drug (ISO)

response to fibroblast growth factor (ISO)

response to glucocorticoid (ISO)

response to lipopolysaccharide (ISO)

response to organic substance (ISO)

response to ozone (ISO)

response to silicon dioxide (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

cytoplasm (ISO)

endoplasmic reticulum (ISO)

extracellular space (ISO)

nuclear envelope (ISO)

rough endoplasmic reticulum (ISO)

secretory granule (ISO)

Molecular Function

polychlorinated biphenyl binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

forkhead class A signaling pathway (ISO)

References

References - curated


1.	Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2.	OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data

Scgb1a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955599	688,414 - 690,644 (-)	NCBI	ChiLan1.0	ChiLan1.0

SCGB1A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	62,405,103 - 62,423,195 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	62,419,033 - 62,423,195 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	62,186,507 - 62,190,678 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	61,943,099 - 61,947,243 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	61,943,098 - 61,947,242	NCBI
Celera	11	59,515,913 - 59,520,084 (+)	NCBI
Cytogenetic Map	11	q12.3	NCBI
HuRef	11	58,514,572 - 58,518,782 (+)	NCBI		HuRef
CHM1_1	11	62,069,549 - 62,073,720 (+)	NCBI		CHM1_1

Scgb1a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	9,061,006 - 9,065,320 (-)	NCBI	GRCm39		mm39
GRCm38	19	9,083,642 - 9,087,956 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	9,083,636 - 9,087,958 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	9,158,132 - 9,162,446 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	19	9,150,685 - 9,154,970 (-)	NCBI			mm8
Celera	19	8,844,116 - 8,848,457 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI

Scgb1a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	1	225,279,698 - 225,283,246 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	225,279,676 - 225,283,326 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	232,216,740 - 232,220,289 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	211,758,103 - 211,761,651 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	211,916,532 - 211,920,081 (-)	NCBI
Celera	1	203,487,454 - 203,490,852 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

SCGB1A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	61,133,649 - 61,137,873 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	61,133,649 - 61,137,873 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	57,774,560 - 57,780,334 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

SCGB1A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	18	54,187,487 - 54,191,482 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	18	54,187,487 - 54,191,493 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Scgb1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936581	798,738 - 801,614 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SCGB1A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	9,297,283 - 9,302,165 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	9,297,282 - 9,302,204 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	8,570,790 - 8,575,683 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SCGB1A1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	11,470,091 - 11,474,915 (-)	NCBI
ChlSab1.1 Ensembl	1	11,470,195 - 11,474,149 (-)	Ensembl

Scgb1a1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624926	1,029,120 - 1,030,250 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005414799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005414800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013510070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01076666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01226803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_005414799 ⟹ XP_005414856

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955599	688,414 - 690,644 (-)	NCBI

Sequence:

show sequence

CAGTGCATCTCATAGGCAGAGCCCTCCCCGGCCCCCCTGCAGGCACTGCCTGGAGGGTATAAGA
GGCCCCCGGCCGCAGCCGACACACACTCCGTGAGACCTCCGGCCTGGGACACCAGCTCCTCCTG
CCTTCCTCCATGAAGCTCAGCACCGCTGTCGCCCTGCTCATGCTGGCATGCAGCTGCCCCTCTG
GTTCTGCGAAGACGTGCCCGTCGTTCCACAGCGTCCTGCAGAACTTCCTGATGGGCACACTGTC
TGGCTACGAGAGCACAGTGGAGCCCTTCCAGCCAGACCAGGAGATGAAGGAGGCGGGGGCCCGG
ATGAAGATGCTGGTGGACAGCCTGCCCAAGGGCATCCGGGAGGCGGTGCTGAAGCTCTCGGAAA
AGATAGTAAAAACCAGTGAGTGTGCTTAGAATTCAGCAACCCAAGGCCTGCTGGACTCAAAGCT
GAAGATGTCCCCCGACCACCCCACCCCTGCCCGCGGCCCCCTTGGCTTTGCAATAAACCTCCAG
CATTGCACTCAG

hide sequence

RefSeq Acc Id:

XM_005414800 ⟹ XP_005414857

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955599	688,414 - 689,762 (-)	NCBI

Sequence:

show sequence

TACAAATAATAATTAGTGCTAATAACAGCGTGCAGCACCGACCCAGCGCTGAGAACGCCCACCC
CGGCCTGCGCCCTTGCCCTGCCGTCCTTCCTGTTCTTGCAGCAACCCAAGGGGCAGGGCTCTCG
CTCTCACTGCACAGAGGAGGATGCGGAGCCCCTGCAGGGTCGCTCACTGGCCAGTACGCGGTTC
TGCGAAGACGTGCCCGTCGTTCCACAGCGTCCTGCAGAACTTCCTGATGGGCACACTGTCTGGC
TACGAGAGCACAGTGGAGCCCTTCCAGCCAGACCAGGAGATGAAGGAGGCGGGGGCCCGGATGA
AGATGCTGGTGGACAGCCTGCCCAAGGGCATCCGGGAGGCGGTGCTGAAGCTCTCGGAAAAGAT
AGTAAAAACCAGTGAGTGTGCTTAGAATTCAGCAACCCAAGGCCTGCTGGACTCAAAGCTGAAG
ATGTCCCCCGACCACCCCACCCCTGCCCGCGGCCCCCTTGGCTTTGCAATAAACCTCCAGCATT
GCACTCAG

hide sequence

RefSeq Acc Id:

XM_013510070 ⟹ XP_013365524

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955599	688,414 - 689,285 (-)	NCBI

Sequence:

show sequence

ACAGCTCTGGTGGAAATGGAGGCTCCCGGTGGCCTCTGGGTCAGATCCTCCTCTCCCCATCACC
ACCACTGCCCCTCCTGGGCCGGCGTTGGCGGCTGGCCCACACCCACACCCTCTGCCTCCACACC
AGGTTCTGCGAAGACGTGCCCGTCGTTCCACAGCGTCCTGCAGAACTTCCTGATGGGCACACTG
TCTGGCTACGAGAGCACAGTGGAGCCCTTCCAGCCAGACCAGGAGATGAAGGAGGCGGGGGCCC
GGATGAAGATGCTGGTGGACAGCCTGCCCAAGGGCATCCGGGAGGCGGTGCTGAAGCTCTCGGA
AAAGATAGTAAAAACCAGTGAGTGTGCTTAGAATTCAGCAACCCAAGGCCTGCTGGACTCAAAG
CTGAAGATGTCCCCCGACCACCCCACCCCTGCCCGCGGCCCCCTTGGCTTTGCAATAAACCTCC
AGCATTGCACTCAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005414856	(Get FASTA)	NCBI Sequence Viewer
	XP_005414857	(Get FASTA)	NCBI Sequence Viewer
	XP_013365524	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_005414856 ⟸ XM_005414799
- Peptide Label:	isoform X2
- Sequence:	show sequence MKLSTAVALLMLACSCPSGSAKTCPSFHSVLQNFLMGTLSGYESTVEPFQPDQEMKEAGARMKM LVDSLPKGIREAVLKLSEKIVKTSECA hide sequence

RefSeq Acc Id:	XP_005414857 ⟸ XM_005414800
- Peptide Label:	isoform X3
- Sequence:	show sequence MRSPCRVAHWPVRGSAKTCPSFHSVLQNFLMGTLSGYESTVEPFQPDQEMKEAGARMKMLVDSL PKGIREAVLKLSEKIVKTSECA hide sequence

RefSeq Acc Id:	XP_013365524 ⟸ XM_013510070
- Peptide Label:	isoform X1
- Sequence:	show sequence MEAPGGLWVRSSSPHHHHCPSWAGVGGWPTPTPSASTPGSAKTCPSFHSVLQNFLMGTLSGYES TVEPFQPDQEMKEAGARMKMLVDSLPKGIREAVLKLSEKIVKTSECA hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Scgb1a1	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Scgb1a1	secretoglobin family 1A member 1		secretoglobin, family 1A, member 1 (uteroglobin)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)