Pex14 (peroxisomal biogenesis factor 14)

Gene: Pex14 (peroxisomal biogenesis factor 14) Chinchilla lanigera

Analyze

Symbol:

Pex14

Name:

peroxisomal biogenesis factor 14

RGD ID:

9033162

Description:

ENCODES a protein that exhibits beta-tubulin binding (ortholog); identical protein binding (ortholog); microtubule binding (ortholog); INVOLVED IN cellular response to reactive oxygen species (ortholog); microtubule anchoring (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN fibrillar center (ortholog); peroxisomal membrane (ortholog); peroxisome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

peroxisomal membrane protein PEX14

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,980,700 - 3,129,721 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	2,981,026 - 3,129,721 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

chromosome 1p36 deletion syndrome (ISO)

genetic disease (ISO)

immunodeficiency 14 (ISO)

ovarian cyst (ISO)

peroxisomal biogenesis disorder (ISO)

peroxisome biogenesis disorder 13A (ISO)

peroxisome biogenesis disorder 1A (ISO)

Peroxisome Biogenesis Disorder, Complementation Group K (ISO)

Zellweger syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to reactive oxygen species (ISO)

microtubule anchoring (ISO)

negative regulation of DNA-templated transcription (ISO)

peroxisome organization (ISO)

peroxisome transport along microtubule (ISO)

protein import into peroxisome matrix (ISO)

protein import into peroxisome matrix, docking (ISO)

protein import into peroxisome matrix, substrate release (ISO)

protein import into peroxisome matrix, translocation (ISO)

protein-containing complex assembly (ISO)

Cellular Component

fibrillar center (ISO)

peroxisomal membrane (ISO)

peroxisome (ISO)

protein-containing complex (ISO)

Molecular Function

beta-tubulin binding (ISO)

identical protein binding (ISO)

microtubule binding (ISO)

protein binding (ISO)

protein transmembrane transporter activity (ISO)

protein-macromolecule adaptor activity (ISO)

signaling receptor binding (ISO)

transcription corepressor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adrenoleukodystrophy pathway (ISO)

carnitine-acylcarnitine translocase deficiency (ISO)

fatty acid beta degradation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Pex14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,980,700 - 3,129,721 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	2,981,026 - 3,129,721 (-)	NCBI	ChiLan1.0	ChiLan1.0

PEX14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	10,474,950 - 10,630,758 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	10,472,288 - 10,630,758 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	10,535,007 - 10,690,815 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	10,457,590 - 10,613,402 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	10,469,284 - 10,625,079	NCBI
Celera	1	9,646,407 - 9,802,209 (+)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	9,688,564 - 9,844,851 (+)	NCBI		HuRef
CHM1_1	1	10,522,760 - 10,678,540 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	10,018,554 - 10,174,355 (+)	NCBI		T2T-CHM13v2.0

Pex14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	149,044,992 - 149,184,300 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	149,044,992 - 149,184,333 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	148,960,535 - 149,099,843 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	148,960,535 - 149,099,876 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	148,334,644 - 148,473,921 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	147,804,335 - 147,943,612 (-)	NCBI		MGSCv36	mm8
Celera	4	151,224,014 - 151,367,395 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	78.87	NCBI

Pex14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	164,682,876 - 164,819,352 (-)	NCBI		GRCr8
mRatBN7.2	5	159,399,776 - 159,536,260 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	159,399,776 - 159,536,272 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	162,116,476 - 162,252,953 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	163,938,080 - 164,073,727 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	163,894,450 - 164,030,099 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	165,782,895 - 165,918,445 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	165,782,895 - 165,918,445 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	169,433,225 - 169,568,626 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	166,038,317 - 166,174,652 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	166,048,504 - 166,184,840 (-)	NCBI
Celera	5	157,671,940 - 157,807,205 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

PEX14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	217,596,325 - 217,752,497 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	216,242,429 - 216,398,429 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	9,234,928 - 9,391,086 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	10,459,863 - 10,614,187 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	10,459,884 - 10,614,187 (+)	Ensembl	panpan1.1		panPan2

PEX14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	85,379,378 - 85,389,175 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	81,981,475 - 81,990,564 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	86,111,196 - 86,124,207 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	86,114,196 - 86,124,084 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	82,862,365 - 82,871,454 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	83,864,867 - 83,873,956 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	84,927,777 - 84,936,866 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101959362
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	33,780,359 - 33,977,224 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936623	4,265,559 - 4,289,590 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936623	4,313,147 - 4,462,528 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936623	4,313,186 - 4,462,462 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PEX14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	70,737,905 - 70,872,072 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	70,737,871 - 70,872,074 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	64,670,674 - 64,805,059 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PEX14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	121,152,514 - 121,309,888 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	121,152,498 - 121,309,919 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	25,065,864 - 25,223,768 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pex14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	2,082,709 - 2,224,899 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	2,082,709 - 2,224,235 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005404016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01059013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01059014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01059015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01059016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01059017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01059018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01091917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000009750 ⟹ ENSCLAP00000009621

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955486	2,980,700 - 3,129,721 (-)	Ensembl

RefSeq Acc Id:

XM_005404016 ⟹ XP_005404073

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955486	2,981,026 - 3,129,721 (-)	NCBI

Sequence:

show sequence

TCCACAGTAGCCAGGTTCTATCCCGAGCAGTGCTGTAACTGTGCTGGTCCTGGGCTGGTGAGCA
GGGGTCGGGTTTTGGATCTTTTTATTTCTAGAGCCTAAGAGGAGGCACTCGGGAGAGTTACAAC
GAGTGGCTAAAAACCTATTTCCACGTTTCTTTACATTCATTCATTTACTGAATACTTAGATCAT
AAATGTGCACAGGGCACTCTGGGGACTACGGAGATTTAATTCAAGACTAGTAATACTCCTATGA
CAATGAAAGAAATGAATAGAATGACTCCTTCCAATGAACAGACTCCTTTGGATTTCCTCGTAAG
GCAGAGACCTATGGGAGTTATTGGAGGTGACCCCGACGCCGATCTACCCTTTGCCCCAGCCCGC
CCTAATCGACGGGCTCAGTTGCTTCTACTTTAGTCTGAGGCGCAGAACCAGAGCGAGGGCTCTT
GGGAGGAATCTCGTCCAGCGGCGGTAGATTAGTCAGGCCTGAAAAAGATGGCGTCCTCGGAGCA
GGCAGAGCAGCCGAAACAGCCGAGCTCTACTCCAGGAAGCGAAAATGTGGTGCCTCGAGAGCCG
TTGATTGCCACAGCAGTGAAGTTTCTACAGAATTCCCGGGTCCGCCAGAGCCCACTTGCGACCA
GGAGAGCGTTCCTTAAGAAGAAAGGGCTGACTGATGAAGAGATTGACCTGGCTTTCCAGCAGTC
GGGCACTGCTGCCGACGAGCCTGCACCCCTGGGCCCAGCCACGCAGGTGGTTCCTCTGCAGCCT
CCCCACCTCATTTCGCAGCCATGCAGCCCCGCAGGCTCCCGGTGGCGGGATTACGGTGCTCTGG
CCATCATCCTGGCAGGAATCGCATTCGGCTTCCACCAGCTCTACAAGAAGTACCTGCTGCCCCT
CATCCTGGGTGGCCGCGAGGACAGGAAGCAGCTGGAGAGGATGGCGGCGAGTCTCTCCGAGCTG
AGTGGCAGTGTGGCCCAGACAGTGACCCAGGTGCAGACGACGCTGGCCTCCGTGCAGGAGCTGC
TGAGGCAGCAGCAGCAGAAAGTCCAGGAGCTGGCCCATGAGCTGGCCACCGCCAAGGCCACCTC
GTCCACCAACTGGATCCTGGAGTCCCAGAACATCAGCGAGCTCAAGGCGGAGATTAACTCCCTG
AAAGGGCTGCTTTTGAATCGGAGGCAGTTCCCGCCGTCACCGTCGGCCCCCAAGATCCCCTCCT
GGCAGATCCCTGTCAAGGCGCCGTCACCCTCCAGCCCCGCAGCCGCCAACCATCACAGCAGCAG
TGACATCTCCCCGGTGAGCAACGAGTCCACGTCGCCGTCACCCGGGAAGGAGAGCCACAGCCCT
GAGGGCTCCACGGCCGCCTACCACCTGCTGGGCCCGCAGGAGGAGGCCGAGGGTGCGGTGGACG
TGAAGGGCCAGGTGCGCATGGAGGTGCAGGGCGAGGAGGAGAAGCGGGAGGACGAGGAGGACGA
GGAGGACGACGTGGGCCGCGCGGACGAGGAGGACGTGCTGGGGGTGCAGCGGGAGGACCGCCGG
GGCGGGGACGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACG
AGAACGAGCTGGACTAGGGCCCCTTCAAGGGGCGCCGGCCGCGGGTGGCACTTGGCACCAGCCC
CGCCCTCTGCCCACTCTGGGACAGCGGCTGGAGCTGCGCCATACGAGGTTGGTGTGTGCCCAGC
AGCCTGTCACCTCGGCCTGGTGGCCCTGGCCCAGTCCCCAAGGCGGGCGGCACCCGGGCCTGGG
CTCCAGCCCTGCCCACCCTCCCGGGCCACGCCCCATCCAGGGCATTTGCCAAGTGTCTTGACTA
ACGTGGCACTGTGCATGGCACGAGCTCGTGTTGTCACCGCCTCCTCCTCAGGGGGAGGAGCTGC
AGTCCCTTGGTCTCTGCTGTCCCCTGGGCCTGGCCCTCGGCTCCTTCTTTGGCGTGTTTCCAAC
AGCCAGAGCCCTGGACTCACTGTCCAGCAGCAAGGGCCTGCCAAGCCCATCCCACGTGCCCTGC
CACCCTCAGCCAGTGGCATCGCCCTGCGCTTGTGCCCTCCTTGCCCTGCTCCGCCCAGCCCATG
GCGAGACGTGGTCCCCGCTACAGTGGAGCGGTAGCAGGGCCTCCTGACCCGGGCCGCGCCGGTC
CTCCCGGAAGCACGCGTCCCCCTGCGTGACCACCTACAGGTTCTGGAACATGGGCGAGACTGTA
CATAACTGTAATAAAGACGAGTCGCCACTACCTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005404073	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000009621
	ENSCLAP00000009621.1

RefSeq Acc Id:

XP_005404073 ⟸ XM_005404016

- UniProtKB:

A0A8C2V374 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASSEQAEQPKQPSSTPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEID
LAFQQSGTAADEPAPLGPATQVVPLQPPHLISQPCSPAGSRWRDYGALAIILAGIAFGFHQLYK
KYLLPLILGGREDRKQLERMAASLSELSGSVAQTVTQVQTTLASVQELLRQQQQKVQELAHELA
TAKATSSTNWILESQNISELKAEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKAPSPSSPAAA
NHHSSSDISPVSNESTSPSPGKESHSPEGSTAAYHLLGPQEEAEGAVDVKGQVRMEVQGEEEKR
EDEEDEEDDVGRADEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNENELD

hide sequence

RefSeq Acc Id:

ENSCLAP00000009621 ⟸ ENSCLAT00000009750

Protein Domains

Peroxisome membrane anchor protein Pex14p N-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006671	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000009750	ENTREZGENE
	ENSCLAT00000009750.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	PEX14	UniProtKB/TrEMBL
	Pex14_N	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Pex14	ENTREZGENE
PANTHER	PEROXISOMAL MEMBRANE PROTEIN PEX14	UniProtKB/TrEMBL
	PTHR23058	UniProtKB/TrEMBL
Pfam	Pex14_N	UniProtKB/TrEMBL
UniProt	A0A8C2V374	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB