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Gene: Gramd2a (GRAM domain containing 2A) Chinchilla lanigera

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Symbol:

Gramd2a

Name:

GRAM domain containing 2A

RGD ID:

9032194

Description:

ENCODES a protein that exhibits phosphatidylinositol binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN endoplasmic reticulum-plasma membrane tethering (ortholog); regulation of store-operated calcium entry (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); Tay-Sachs disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); organelle membrane contact site (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GRAM domain containing 2; GRAM domain-containing protein 2; Gramd2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	4,954,223 - 4,960,280 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	4,936,357 - 4,960,643 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

Tay-Sachs disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum-plasma membrane tethering (ISO)

regulation of store-operated calcium entry (ISO)

Cellular Component

endoplasmic reticulum membrane (ISO)

organelle membrane contact site (ISO)

plasma membrane (ISO)

Molecular Function

phosphatidylinositol binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Gramd2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	4,954,223 - 4,960,280 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	4,936,357 - 4,960,643 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRAMD2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	72,159,806 - 72,197,787 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	72,159,806 - 72,197,787 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	72,452,147 - 72,490,128 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	70,239,202 - 70,277,180 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	49,338,482 - 49,376,472 (-)	NCBI		Celera
Cytogenetic Map	15	q23	NCBI
HuRef	15	49,282,391 - 49,320,733 (-)	NCBI		HuRef
CHM1_1	15	72,570,298 - 72,608,273 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	69,976,533 - 70,014,515 (-)	NCBI		T2T-CHM13v2.0

Gramd2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	59,587,116 - 59,626,156 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	59,587,427 - 59,626,157 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	59,679,833 - 59,718,873 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	59,680,144 - 59,718,874 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	59,555,571 - 59,564,231 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	59,505,770 - 59,514,430 (+)	NCBI		MGSCv36	mm8
Celera	9	56,935,077 - 56,943,737 (+)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	32.05	NCBI

Gramd2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	68,975,529 - 69,013,575 (+)	NCBI		GRCr8
mRatBN7.2	8	60,079,744 - 60,117,788 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	60,080,338 - 60,115,842 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	65,614,895 - 65,639,991 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	63,887,816 - 63,912,914 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	61,757,271 - 61,782,369 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	64,503,058 - 64,539,149 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	64,531,594 - 64,539,367 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	64,266,714 - 64,303,816 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	63,536,874 - 63,544,192 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	59,522,697 - 59,560,686 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

GRAMD2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	61,424,978 - 61,462,105 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	65,589,194 - 65,626,323 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	51,111,249 - 51,148,379 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	69,874,593 - 69,912,241 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	69,874,593 - 69,912,241 (-)	Ensembl	panpan1.1		panPan2

GRAMD2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	35,679,571 - 35,711,642 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	35,681,713 - 35,713,054 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	35,616,627 - 35,648,632 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	35,883,954 - 35,916,247 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	35,886,120 - 35,916,212 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	35,837,346 - 35,869,289 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	35,865,209 - 35,897,197 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	36,120,073 - 36,152,105 (-)	NCBI		UU_Cfam_GSD_1.0

Gramd2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	113,702,443 - 113,739,942 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	31,550,406 - 31,587,981 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	31,550,506 - 31,588,377 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100627175
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	169,638,097 - 169,664,774 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GRAMD2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	11,255,629 - 11,299,132 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	11,256,792 - 11,300,174 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	130,275,502 - 130,316,723 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gramd2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	1,852,433 - 1,858,359 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	1,825,123 - 1,860,695 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005393624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01042486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01042487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01013410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000017602 ⟹ ENSCLAP00000017432

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955450	4,954,223 - 4,960,039 (+)	Ensembl

Ensembl Acc Id:

ENSCLAT00000017603 ⟹ ENSCLAP00000017433

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955450	4,954,240 - 4,960,280 (+)	Ensembl

Ensembl Acc Id:

ENSCLAT00000017604 ⟹ ENSCLAP00000017434

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955450	4,956,714 - 4,960,039 (+)	Ensembl

RefSeq Acc Id:

XM_005393624 ⟹ XP_005393681

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955450	4,936,357 - 4,960,643 (+)	NCBI

Sequence:

show sequence

GGGCAAGTGAGGCTGCAGCGGGCAGCCGCTCTTCCGCCTGCGTCAGTCGCGCTACGCTGGAAAC
GGCGCGCAGTCTGGTTGCCATCTCGCCTTTGACCGCATGTAGCTGTCGCGGAGTTGGGTGGCTG
CTTCTTGGAAATACAGATCATCGTCCGGCGCTGCGCTCCCTCCCGCCCCCTCCACCGGATCCAG
ACCCGTCGTTCTCTGCTGGGCTGCAGCCGCCCAGGTTCCTGCTCCTTATTCACAGAGTGACCGC
AACGCGGGACTTTGTGACCTATTCTGTATCCCCGCCCCGCCTTGCCTGGGCCCTGCTCTTTGGC
TGCCCCATCTTCCCTGGTCAGGCCCTGGGCCTACTCCACCCGGGCAGCCACCAACAAATGAACG
GAAAGACGGCTAATCGGAAGAGCCCTGGGTCCTACACAGAGAATCCAGACAGGGCCAAGGGGGC
CCCGGACTGCACTGAGGCCCCTTCTATTCAGAGTCTGCACTGGCCAGAAGGCTTGAAGGGCGCA
GAGATAAAGAAGGATGGCCGAGAAGGGACACTACTAAGTAAATACAACCAGCAATACCACAAGC
TCTTTAAGGACATCCCCTTGGAGGAGATGGTGCTCAAAGTGTGCTCCTGTGCCCTCCAGAGGGA
CCTCCTTGTCCAGGGCCGCCTCTACATCTCCCCCAACTGGCTCTGCTTCCACGCCAGCCTCTTC
GGCAAGGACATCAAGGTGGTCATTCCCGTGGTGTCTGTGCAAACGGTGAAGAAACACAAGGTGG
CGCGACTCCTCCCCAATGGCTTGGCCATCACCACCAACACCCGCCAGAAGTATGTCTTTGTGTC
GCTGCTCTCCCGGGACAGCGTGTATGACGTGCTGAGGAGGGTCTGCACGCACCTGCAGCCTTCC
AGCAGTAAGAGCCTGAGCGTGAGGAACTTCCCAGAGGAACCCGAGTGCAAGTCTCTGGAAGTCC
TCATCCCTGAGATGAAGTGGAGAAAAATATGCCCTGCCACCAGGTCGTTGTTGCTGTCAGACAA
TATCCCCTGCATCCCTCAGGAGTCGCTGGACTCCACAGATGGCCTCTTCCCCTCCGGGAAGCCT
CGGGGGCCTGAAGATGCTGCTTGTGAGACCCAGGAGCAGCAGGAAGAGCCAGCGAGAGAGCAGG
AGCTGCCCCTCTGGGATTCCCATCTCCTCAAGGTCATCTTCATGCTGATCTGCTTCTTGGTCGT
GTCCTCGTCCTATCTTGCATTTCGCATCTCCCGGCTGGAACAGCAGCTGTGCTCCTTGGATTGG
GATGGGCCAGTCCCTGGGCACAGGTAACAGCTGCCTGGCCTTGGTCCTCGCATCTCTCCAAGAA
GAATGCTCAGGTGCTAAGACTGGTTTGTGCTGCTGCCGTGCTGAGGCCCCGTGTGAAGGGAACA
TTCCCGATCCCCCTCCTCCCCGGCTCCTCCTGCCCTCCGCCAGTGAGCTGAAGCACCTGTTTAC
AAAGTGACCAGCTCCTCCAGATCTGAGATTCGAACAGAAAGCTAGATTCTTTGAAGCAGCTGAG
GAATTCTGTATACTAAGCTGCCGCAGCCACTTCAATGAATAACATTTAACTTGCTCCTTGGAGA
CCGCTCTAGCACACAGGCTGAGCCCTGGGGGCTGCCTCAAGAGACAAAGGCTACACTTTGCGAC
CTGGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005393681	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000017432.1
	ENSCLAP00000017433
	ENSCLAP00000017433.1
	ENSCLAP00000017434.1

RefSeq Acc Id:

XP_005393681 ⟸ XM_005393624

- UniProtKB:

A0A8C2VQP6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNGKTANRKSPGSYTENPDRAKGAPDCTEAPSIQSLHWPEGLKGAEIKKDGREGTLLSKYNQQY
HKLFKDIPLEEMVLKVCSCALQRDLLVQGRLYISPNWLCFHASLFGKDIKVVIPVVSVQTVKKH
KVARLLPNGLAITTNTRQKYVFVSLLSRDSVYDVLRRVCTHLQPSSSKSLSVRNFPEEPECKSL
EVLIPEMKWRKICPATRSLLLSDNIPCIPQESLDSTDGLFPSGKPRGPEDAACETQEQQEEPAR
EQELPLWDSHLLKVIFMLICFLVVSSSYLAFRISRLEQQLCSLDWDGPVPGHR

hide sequence

Ensembl Acc Id:

ENSCLAP00000017434 ⟸ ENSCLAT00000017604

Ensembl Acc Id:

ENSCLAP00000017432 ⟸ ENSCLAT00000017602

Ensembl Acc Id:

ENSCLAP00000017433 ⟸ ENSCLAT00000017603

Protein Domains

GRAM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011975	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000017602.1	UniProtKB/TrEMBL
	ENSCLAT00000017603	ENTREZGENE
	ENSCLAT00000017603.1	UniProtKB/TrEMBL
	ENSCLAT00000017604.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
InterPro	GRAM	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
	RAMD2A	UniProtKB/TrEMBL
NCBI Gene	Gramd2	ENTREZGENE
PANTHER	GRAM DOMAIN-CONTAINING PROTEIN 2A	UniProtKB/TrEMBL
	PTHR46973	UniProtKB/TrEMBL
Pfam	GRAM	UniProtKB/TrEMBL
SMART	GRAM	UniProtKB/TrEMBL
UniProt	A0A8C2VNP4_CHILA	UniProtKB/TrEMBL
	A0A8C2VQP6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VTF0_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-02	Gramd2a	GRAM domain containing 2A	Gramd2	GRAM domain containing 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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