Rrp8 (ribosomal RNA processing 8)

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Gene: Rrp8 (ribosomal RNA processing 8) Chinchilla lanigera

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Symbol:

Rrp8

Name:

ribosomal RNA processing 8

RGD ID:

9016401

Description:

ENCODES a protein that exhibits methylated histone binding (ortholog); INVOLVED IN cellular response to glucose starvation (ortholog); energy homeostasis (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); neuronal ceroid lipofuscinosis (ortholog); FOUND IN chromatin silencing complex (ortholog); cytosol (ortholog); eNoSc complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ribosomal RNA processing 8, methyltransferase, homolog; ribosomal RNA processing 8, methyltransferase, homolog (yeast); ribosomal RNA-processing protein 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	22,311,038 - 22,316,144 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	22,311,038 - 22,316,144 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

neuronal ceroid lipofuscinosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to glucose starvation (ISO)

energy homeostasis (ISO)

intrinsic apoptotic signaling pathway by p53 class mediator (ISO)

negative regulation of cell cycle (ISO)

negative regulation of DNA-templated transcription (ISO)

rDNA heterochromatin formation (ISO)

regulation of G1 to G0 transition (ISO)

regulation of transcription by glucose (ISO)

Cellular Component

chromatin silencing complex (ISO)

cytosol (ISO)

eNoSc complex (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

plasma membrane (ISO)

rDNA heterochromatin (ISO)

Molecular Function

methylated histone binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Rrp8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	22,311,038 - 22,316,144 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	22,311,038 - 22,316,144 (-)	NCBI	ChiLan1.0	ChiLan1.0

RRP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	6,595,072 - 6,603,616 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	6,595,072 - 6,603,616 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	6,616,302 - 6,624,846 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	6,577,728 - 6,581,387 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	6,740,219 - 6,743,878 (-)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	6,280,081 - 6,283,817 (-)	NCBI		HuRef
CHM1_1	11	6,620,046 - 6,623,782 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	6,653,543 - 6,662,088 (-)	NCBI		T2T-CHM13v2.0

Rrp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	105,380,937 - 105,386,592 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	105,380,937 - 105,386,592 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	105,731,730 - 105,737,385 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	105,731,730 - 105,737,385 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	112,880,723 - 112,885,014 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	105,606,030 - 105,610,321 (-)	NCBI		MGSCv36	mm8
Celera	7	106,003,509 - 106,007,800 (-)	NCBI		Celera
Cytogenetic Map	7	E3	NCBI
cM Map	7	55.97	NCBI

Rrp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	169,489,829 - 169,500,551 (-)	NCBI		GRCr8
mRatBN7.2	1	160,081,092 - 160,088,709 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	160,084,295 - 160,089,331 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	168,107,178 - 168,111,204 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	175,293,176 - 175,297,202 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	168,194,934 - 168,198,960 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	170,574,670 - 170,578,693 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	170,574,349 - 170,579,616 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	177,580,522 - 177,584,545 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	163,477,028 - 163,481,051 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	163,572,506 - 163,576,528 (-)	NCBI
Celera	1	158,016,713 - 158,020,738 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

RRP8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	8,933,905 - 9,040,858 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	8,899,731 - 9,004,646 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	6,630,695 - 6,735,711 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	6,314,285 - 6,418,557 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	6,415,003 - 6,418,414 (-)	Ensembl	panpan1.1		panPan2

RRP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	29,907,555 - 29,917,142 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	29,907,361 - 29,918,408 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	29,609,154 - 29,619,614 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	30,733,473 - 30,743,933 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	30,733,473 - 30,737,354 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	30,054,253 - 30,064,707 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	30,219,908 - 30,230,374 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	30,415,227 - 30,425,693 (-)	NCBI		UU_Cfam_GSD_1.0

Rrp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	56,013,586 - 56,018,997 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936842	657,727 - 661,757 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936842	656,508 - 661,894 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RRP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	3,152,209 - 3,162,540 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	3,152,162 - 3,169,380 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	3,810,391 - 3,814,833 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RRP8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	58,221,861 - 58,225,470 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	58,221,869 - 58,225,329 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	156,047,610 - 156,051,373 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rrp8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	8,092,664 - 8,096,358 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	8,089,320 - 8,096,447 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005380167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01015452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01188088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023696 ⟹ ENSCLAP00000023474

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955414	22,311,038 - 22,316,144 (-)	Ensembl

RefSeq Acc Id:

XM_005380167 ⟹ XP_005380224

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955414	22,311,038 - 22,316,144 (-)	NCBI

Sequence:

show sequence

GCGACCCGGCGTGTTGGCGGCCGCTCTGACTTGAGGAAGCTGCGCTGAGCACGTGGAGGGGATC
TTAATTTTTGCGACTCTGCCCTCGCGACCCGCATGTTCGAGGAGCCTGAGTGGGCCGAGGCGGC
CCCAGTAGTCGCGGGCCTCAGTCCCGTAACCTCACGGCCCCGGCCAGCGGCAGCCGCGCAAATC
AAGGGCTCTAGGCGCCGCCAGCTCTTGGCCACCTTACGAGTTCTGGAAGCAGCGTCTCTTTCCC
AGCAGTCCACCAGCTTCCCCAGCAGTGACTCTGAGGAGGAGGTAGAAAGAAAGAAGAAACACCC
CAAAAGGTCCCCATTTGCTAACACCTCTGCCAAAGTAGGGGAGAAAAGGAAAAAATGTCAAAAA
CTGGGCCCATCTCCAGGTGACTGTGAGGACCACAAAGTAGAAAAGAAGAAATGCCGCAAACAAG
CTCTTCTCTATAGTGACTCTGCCAAAGAAGAGAAAAGAAAGAGAAAATGCCCGGAACAGGCCCC
TTCAAACCCAGCCCAGCACAAAGACAGTGTCGACCAAACAGGTCACAAATCCTGGAAGAGTGGT
ACTACAAATCCAGAGCCAAGCTCTGGATCCATTTCCACTAAGCCCCCCAATCCCTTAACCCGGA
AGCAGTGGCGGAACCGGCAGAAGAACAAGCGGAGACACAAGAACAAATTTCGGCCACTCCAGGC
ACCAGAGGAGATTTCCGCTGAGGCCTCCAAGGCTGCTACAGAGGAGTCAGAGGGGCCTCCTACC
CGCAAGGCAGACAGTCATGAAGCTCGGGCAGAGGCCCTGCGAGCCCGCATGGCACAGCGGTTGG
ATGGGGCCCGATTTCGCTACCTTAATGAGCAGCTGTATTCAGGGCCCAGCAGTGCTGCACAGCG
CCTTTTCCAGGAAGACCCTGAGGCTTTTCTCCTCTACCATCGAGGCTTCCAGAGCCAAGTGAAG
AAGTGGCCACTGCAGCCAGTAGACCGCATCATCAGGGATCTTCGCCAGCGGCCTGCATCTCTGG
TAGTGGCTGACTTTGGCTGTGGGGATTGCCGCCTAGCTTCAAGTATCCGGAACCCTGTACACTG
CTTTGACCTGGCCTCACTGGACCCCAGGGTCACTGTGTGTGACATGGCCCAGGTGCCTCTGGAG
GATGAGTCTGTGGATGTGGCTGTGTTTTGTCTTTCACTGATGGGAACCAACATCAGAGATTTCC
TGGAAGAGGCAAATCGAGTGCTGAAGCCAGGGGGTCTCCTGAAAATAGCTGAGGTCGGCAGCCG
CTTTGAGGATGTTCGGACCTTTCTGGGGGCTGTGACCAAGCTGGGCTTTAAGGTCATCTCCAAG
GACCTGACCAACAGCCACTTCTTCTTGTTTGATTTTGAAAAGACAGGCCCCCCTCGGGTAGGGC
CCAAGGCTCAGCTTGCAGGCTTGAAACTTCAGCCGTGTCTCTACAAGCGAAGGTGACCTCTAAA
CACCTCTTGAAAGTGGAAGCAGGGCCCAGACTCCAGGTTGAGAACTCTGAAGACTGTGTCTAGC
CAGGCTGTGAGCCAGGACCTGGTACGACCTTTCCTCCGTCCCAAGAACGAGGTGTGATGAAGCC
CCTGGCTCAGCTGTGCTCCAGTGCAGGCGCCTTGGTTAGAAAGAAGCCTAAAGTCACTTGAGCA
AGCTAATGAGTAAGAAGGAACAGGGGGATAACTGGGCATCATGGATCACCTCAAATGGTTTGCA
GTTGAAGAGTCTTTGAGTTTGGCTCTTCTTTGCATCTCTCAGAAGACACATGGGCTTTTTGTCT
TGGCCTCTCTGCTCTTCTGATCTATACTGATCAGCCTCTGTTCACCTGTACCTCCTGCTCCTTC
AGGTTCCTACTGCCCAGGCCTTCAAGACTGCAGACAGGCAGCTCTTGATTCATGGTAGTTCTAA
TCCTAACTGCCCCTTACAGCTGAGAGCCATTTAGTGTCTTAGTATCACATTCCTCATTCGGAAA
ATGATAGAATTCCTGTCTTACAGCATTGTTGCGTGTGTTATGTGAGGAAATCTATAGTCAGGGC
TGGGAACATGGGAGGTGCTCAATAAACTAGCTGTGGATATTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005380224	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000023474
	ENSCLAP00000023474.1

RefSeq Acc Id:

XP_005380224 ⟸ XM_005380167

- UniProtKB:

A0A8C2W3L6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFEEPEWAEAAPVVAGLSPVTSRPRPAAAAQIKGSRRRQLLATLRVLEAASLSQQSTSFPSSDS
EEEVERKKKHPKRSPFANTSAKVGEKRKKCQKLGPSPGDCEDHKVEKKKCRKQALLYSDSAKEE
KRKRKCPEQAPSNPAQHKDSVDQTGHKSWKSGTTNPEPSSGSISTKPPNPLTRKQWRNRQKNKR
RHKNKFRPLQAPEEISAEASKAATEESEGPPTRKADSHEARAEALRARMAQRLDGARFRYLNEQ
LYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIIRDLRQRPASLVVADFGCGDCR
LASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPG
GLLKIAEVGSRFEDVRTFLGAVTKLGFKVISKDLTNSHFFLFDFEKTGPPRVGPKAQLAGLKLQ
PCLYKRR

hide sequence

Ensembl Acc Id:

ENSCLAP00000023474 ⟸ ENSCLAT00000023696

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016099	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023696	ENTREZGENE
	ENSCLAT00000023696.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.2150	UniProtKB/TrEMBL
	3.40.50.150	UniProtKB/TrEMBL
InterPro	RRP8	UniProtKB/TrEMBL
	RRP8_N	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
	UbiE/COQ5_MeTrFase_CS	UniProtKB/TrEMBL
NCBI Gene	Rrp8	ENTREZGENE
PANTHER	PTHR12787	UniProtKB/TrEMBL
	RIBOSOMAL RNA-PROCESSING PROTEIN 8	UniProtKB/TrEMBL
Pfam	Methyltransf_8	UniProtKB/TrEMBL
PROSITE	UBIE_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A8C2W3L6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-30	Rrp8	ribosomal RNA processing 8		ribosomal RNA processing 8, methyltransferase, homolog (yeast)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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