Pnpo (pyridoxamine 5'-phosphate oxidase)

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Gene: Pnpo (pyridoxamine 5'-phosphate oxidase) Chinchilla lanigera

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Symbol:

Pnpo

Name:

pyridoxamine 5'-phosphate oxidase

RGD ID:

9009717

Description:

ENCODES a protein that exhibits FMN binding (ortholog); protein homodimerization activity (ortholog); pyridoxal phosphate binding (ortholog); INVOLVED IN pyridoxal phosphate biosynthetic process (ortholog); pyridoxal phosphate metabolic process (ortholog); pyridoxamine metabolic process (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 5 (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pyridoxine-5'-phosphate oxidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	13,183,826 - 13,191,707 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	13,184,861 - 13,190,933 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant distal hereditary motor neuronopathy 5 (ISO)

epilepsy (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

pyridoxamine 5'-phosphate oxidase deficiency (ISO)

status epilepticus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

pyridoxal phosphate biosynthetic process (ISO)

pyridoxal phosphate metabolic process (ISO)

pyridoxamine metabolic process (ISO)

Cellular Component

cytosol (ISO)

mitochondrion (ISO)

Molecular Function

FMN binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

pyridoxal phosphate binding (ISO)

pyridoxamine phosphate oxidase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypophosphatasia pathway (ISO)

vitamin B6 metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pnpo
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	13,183,826 - 13,191,707 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	13,184,861 - 13,190,933 (-)	NCBI	ChiLan1.0	ChiLan1.0

PNPO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	47,941,571 - 47,949,308 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	47,941,506 - 47,949,308 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	46,018,937 - 46,026,674 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	43,373,916 - 43,381,673 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	43,373,935 - 43,380,653	NCBI
Celera	17	42,471,698 - 42,479,495 (+)	NCBI		Celera
Cytogenetic Map	17	q21.32	NCBI
HuRef	17	41,387,555 - 41,395,352 (+)	NCBI		HuRef
CHM1_1	17	46,083,871 - 46,091,657 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	48,803,361 - 48,811,099 (+)	NCBI		T2T-CHM13v2.0

Pnpo
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	96,828,642 - 96,834,845 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	96,828,651 - 96,834,812 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	96,937,816 - 96,944,019 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	96,937,825 - 96,943,986 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	96,799,130 - 96,805,333 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	96,753,917 - 96,770,309 (-)	NCBI		MGSCv36	mm8
Celera	11	106,585,705 - 106,591,891 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	60.17	NCBI

Pnpo
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	82,421,027 - 82,427,288 (-)	NCBI		GRCr8
mRatBN7.2	10	81,924,584 - 81,930,844 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	81,924,569 - 81,930,871 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	86,872,642 - 86,878,839 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	86,370,690 - 86,376,884 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	81,763,293 - 81,769,477 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	84,874,926 - 84,881,190 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	84,874,927 - 84,881,190 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	84,665,835 - 84,672,099 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	15	45,408,393 - 45,421,097	NCBI
Celera	10	80,686,370 - 80,692,634 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

PNPO
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	17,155,121 - 17,162,880 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	19,120,708 - 19,128,435 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	9,589,253 - 9,596,973 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	9,773,052 - 9,778,922 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	9,773,052 - 9,778,922 (-)	Ensembl	panpan1.1		panPan2

PNPO
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	24,252,895 - 24,258,523 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	24,252,964 - 24,258,106 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	23,719,116 - 23,724,734 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	25,046,154 - 25,052,008 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	25,046,226 - 25,052,004 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	23,816,257 - 23,821,968 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	24,077,084 - 24,082,942 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	24,203,867 - 24,209,469 (+)	NCBI		UU_Cfam_GSD_1.0

Pnpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	23,693,129 - 23,700,206 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	13,374,737 - 13,382,071 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	13,374,925 - 13,382,037 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PNPO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	24,192,897 - 24,201,411 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	24,192,848 - 24,201,419 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	23,993,281 - 23,998,372 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PNPO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	68,338,847 - 68,360,492 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	68,338,936 - 68,344,050 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	39,393,051 - 39,398,955 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pnpo
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	4,574,924 - 4,580,032 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	4,574,902 - 4,580,884 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005394258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01043458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01173325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000020443 ⟹ ENSCLAP00000020247

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955451	13,183,826 - 13,191,707 (-)	Ensembl

RefSeq Acc Id:

XM_005394258 ⟹ XP_005394315

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955451	13,184,861 - 13,190,933 (-)	NCBI

Sequence:

show sequence

TCCTTCCTTCCGGGTTTGGACCTCGGCGCTGGGACTTTGGTTCCGAACTCGGCGGAACCGGGGC
CGGCGACGCTGGGTCACGTGGCCCGAGGCTCCCATGACGCGTGGGCTGCGGGGCGTCACGGCGA
CGTTCGGGCGACCTCCCGGGTGGCCCGGCTACCTCCGCCAGCTGTGCGGCCGCGGTGCTGTCAT
GGATCTGGGACCCATGCGCAAGAGTTACTGTGGGGACCGCGAGGCCTTTGAGGAGACTCACCTG
GCCTCGCTGGACCCCATGAAGCAGTTCGCTGCGTGGTTCGAGGAGGCTGTCCAATGTCCTGACG
TAGGGGAAGCCAACGCCATGTGTCTGGCTACCTGCACGAGGGATGGGAAGCCCTCCGCCCGCAT
GGTACTGCTGAAGGGCTTTGGCCAGGACGGCTTCCGCTTCTTCACCAACTTTGAGAGCCGGAAA
GGAAAGGAGCTGGACTCCAATCCGTTTGCCTCCCTTGTCTTCTACTGGGAGCCTCTTCACCGCC
AGGTGCGTGTGGAGGGCCGGGTGCAGAGGCTGCCGGAGGCCGAGGCCGAGAGCTACTTCCACTC
CCGCCCCAAAAGCAGCCAGATCGGGGCCGTGGTGAGCCGCCAGAGCTCCGTGATCCCCGACCGC
GAGTATCTGAGGAAGAAAAACAAGGAACTGGAGCAGCTCTACCAGGACCAGGAGGTGCCCAAGC
CGAAATACTGGGGCGGCTACATGCTGTATCCGCAGGTGATAGAGTTCTGGCAGGGCCAGACGAA
CCGCCTGCACGACCGCATCGTCTTCCGGCGGGGCCTCCCCACAGGGGACTCCGTGGGACCCATG
ACCCGCTGCGGGGAGGAAGGCTGGCTCTACGAGAGACTGGCACCGTGACTCTGGCGTCACTAGT
GACAGCAACGCGGGGCTCAGACGCCTCCCCCGCACAGCCTGTCCCTCCCTCCCTTCCCTTTACC
CAAGCGGTCCCCAGCTGGGTCTCCACCACTGCCTCACAGAGAATCAGAGATGCGAAAGAAAAAG
TCTCCATGGTTTTCTTGACCTTCCCTGTGGTTTTCCCTGTGACTTCCTCCCTGGTGAGCTGGTC
CCCCAGCAGCCCTGTCTGTTGCCATGGGATTCATGCTACCTGAGCCAGAAGAGCCATGCAGACT
TCTCATCAACAACTCACACTGTGAACCAGGCATGGAGATGCACACCTGTAATCCCACCATGCTT
GGGAGGCTGAGGCAGGAGGATTGAAAGTTTGAGCTCTGGCTGGGCACTTTAGCAACTTACCGAG
ACCCTCTCCCAAAATGAAAAATACAGGTAAAATAATAATTTGACTTTGAAATGGGGAGACTCGG
AGCCTGGGGAGTGGTGTGGTTAAGCTGTCCGTGGCAGCCCAGAACCGCAGCTCACAGGGCCACC
CTGGGCCTCCTTCTGTCTGTGTGTGTTCCTCCTCCCACCTCAAAATGCCCCACTGTCTGTGCAT
TCTTTTTTCCCCTTAAACTATCCAGAATTGACTTATTCAAAAAAAGCCTCCCTTGAAGGATATT
TTTATAGCCATTCTCCCACATTGATTGCTGCCTTTCATTGTTTGAAGCACAGCGATGTGGAAAA
GAGATCTTTTGTGTGTGTGCCCGGAATCGAACTCAGGACCCTGTGCTTGCCAAGCAGGCACTTG
TGCCATTGAGCTATACCCCCGGCCCAAAGAGATTAAATCTATTCCTTATATCACCATGGGCCCC
TAGGTAGAAGTGACAGGGACTTCTCAGTATGAGGTGCCTCCTCCAGTTCCTCTCGATGCCTAGG
AGGCGTGGGCTGTCTGCCCAGCAGCAAGGGTTCCGTCCCTCGGAGTATTCAATCCCAGCCAGAC
AGGGAGCGTCGGAAGGCCTTGTGTGCCGCTTCCTCAGGCCAGGACGACTTTAATCAAGCTTGCT
GTCTTGTGTTCATTCTGTGGAAACCGTGTATATATGTGTGTGTGTGTCGGGGAGATACAAATAT
ATGGATTCCATTTTCCAAAAATAAAATTATTAAAGGGATTTGCATTCCCCACCTCTCCTGGAGA
TGAGTCCTA

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Protein Sequences


Protein RefSeqs	XP_005394315	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000020247
	ENSCLAP00000020247.1

RefSeq Acc Id:

XP_005394315 ⟸ XM_005394258

- UniProtKB:

A0A8C2VT33 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTRGLRGVTATFGRPPGWPGYLRQLCGRGAVMDLGPMRKSYCGDREAFEETHLASLDPMKQFAA
WFEEAVQCPDVGEANAMCLATCTRDGKPSARMVLLKGFGQDGFRFFTNFESRKGKELDSNPFAS
LVFYWEPLHRQVRVEGRVQRLPEAEAESYFHSRPKSSQIGAVVSRQSSVIPDREYLRKKNKELE
QLYQDQEVPKPKYWGGYMLYPQVIEFWQGQTNRLHDRIVFRRGLPTGDSVGPMTRCGEEGWLYE
RLAP

hide sequence

Ensembl Acc Id:

ENSCLAP00000020247 ⟸ ENSCLAT00000020443

Protein Domains

Pyridoxamine 5'-phosphate oxidase putative Pyridoxine 5'-phosphate oxidase dimerisation C-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013871	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000020443	ENTREZGENE
	ENSCLAT00000020443.1	UniProtKB/TrEMBL
InterPro	Pyridox_Oxase	UniProtKB/TrEMBL
	Pyridox_Oxase_CS	UniProtKB/TrEMBL
	Pyridox_Oxase_put	UniProtKB/TrEMBL
	Pyridoxamine_oxidase_dimer_C	UniProtKB/TrEMBL
	Split_barrel_FMN-bd	UniProtKB/TrEMBL
NCBI Gene	Pnpo	ENTREZGENE
PANTHER	PTHR10851	UniProtKB/TrEMBL
	PYRIDOXINE-5'-PHOSPHATE OXIDASE	UniProtKB/TrEMBL
Pfam	PNP_phzG_C	UniProtKB/TrEMBL
	Putative_PNPOx	UniProtKB/TrEMBL
PIRSF	Pyd_amn-ph_oxd	UniProtKB/TrEMBL
PROSITE	PYRIDOX_OXIDASE	UniProtKB/TrEMBL
Superfamily-SCOP	FMN-binding split barrel	UniProtKB/TrEMBL
UniProt	A0A8C2VT33	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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Imported Annotations - SMPDB