LOC102030124 (cholesterol 24-hydroxylase) - Rat Genome Database

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Gene: LOC102030124 (cholesterol 24-hydroxylase) Chinchilla lanigera
Analyze
Symbol: LOC102030124 (Ensembl: CYP46A1)
Name: cholesterol 24-hydroxylase
RGD ID: 9007511
Description: ENCODES a protein that exhibits cholesterol 24-hydroxylase activity (ortholog); heme binding (ortholog); steroid hydroxylase activity (ortholog); INVOLVED IN cholesterol catabolic process (ortholog); progesterone metabolic process (ortholog); protein localization to membrane raft (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); chronic obstructive pulmonary disease (ortholog); genetic disease (ortholog); FOUND IN dendrite (ortholog); endoplasmic reticulum membrane (ortholog); postsynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543820,961,365 - 20,985,749 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543820,961,621 - 20,986,260 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC102030124
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543820,961,365 - 20,985,749 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543820,961,621 - 20,986,260 (+)NCBIChiLan1.0ChiLan1.0
CYP46A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,684,298 - 99,727,301 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,684,298 - 99,727,301 (+)EnsemblGRCh38hg38GRCh38
GRCh3714100,150,635 - 100,193,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,220,508 - 99,263,391 (+)NCBINCBI36Build 36hg18NCBI36
Build 341499,220,507 - 99,263,390NCBI
Celera1480,205,602 - 80,248,517 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,333,998 - 80,376,909 (+)NCBIHuRef
CHM1_114100,088,519 - 100,131,398 (+)NCBICHM1_1
T2T-CHM13v2.01493,915,741 - 93,958,738 (+)NCBIT2T-CHM13v2.0
Cyp46a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,300,568 - 108,328,497 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,300,640 - 108,328,493 (+)EnsemblGRCm39 Ensembl
GRCm3812108,334,268 - 108,362,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,334,381 - 108,362,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712109,572,591 - 109,600,444 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612108,782,188 - 108,810,041 (+)NCBIMGSCv36mm8
Celera12109,576,067 - 109,604,342 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.41NCBI
Cyp46a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,011,948 - 133,039,167 (+)NCBIGRCr8
mRatBN7.26127,247,543 - 127,274,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,243,315 - 127,274,760 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,372,445 - 127,399,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,667,502 - 127,694,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,025,379 - 127,052,595 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,242,328 - 132,273,788 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,242,328 - 132,273,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,412,601 - 141,443,684 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,700,554 - 132,731,982 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16132,711,108 - 132,737,620 (+)NCBI
Celera6124,801,923 - 124,833,398 (+)NCBICelera
Cytogenetic Map6q32NCBI
CYP46A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215100,840,224 - 100,882,729 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,056,722 - 100,099,224 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,309,698 - 80,352,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,628,511 - 99,671,218 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1499,628,511 - 99,671,218 (+)Ensemblpanpan1.1panPan2
CYP46A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,064,898 - 68,095,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,041,344 - 68,095,212 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha867,588,798 - 67,617,580 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,352,536 - 68,381,116 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,352,532 - 68,381,111 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,013,336 - 68,042,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,079,753 - 68,108,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,477,349 - 68,506,246 (+)NCBIUU_Cfam_GSD_1.0
LOC101961079
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,591,776 - 6,630,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,451,842 - 3,491,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,451,853 - 3,490,688 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP46A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,661,111 - 120,695,016 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17120,658,781 - 120,695,031 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,276,297 - 128,302,580 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP46A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,641,068 - 77,684,722 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,641,034 - 77,684,741 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605364,780,651 - 64,824,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101708822
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,242,511 - 4,266,975 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247344,242,070 - 4,267,027 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000022915   ⟹   ENSCLAP00000022707
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543820,961,365 - 20,985,749 (+)Ensembl
RefSeq Acc Id: XM_005390418   ⟹   XP_005390475
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543820,961,621 - 20,985,749 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013517290   ⟹   XP_013372744
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543820,961,621 - 20,986,260 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005390475 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372744 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000022707
  ENSCLAP00000022707.1
Reference Protein Sequences
RefSeq Acc Id: XP_005390475   ⟸   XM_005390418
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VYW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372744   ⟸   XM_013517290
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VYW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000022707   ⟸   ENSCLAT00000022915


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000022915 ENTREZGENE
  ENSCLAT00000022915.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro CYP46A1 UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene LOC102030124 ENTREZGENE
PANTHER CHOLESTEROL 24-HYDROXYLASE UniProtKB/TrEMBL
  PTHR24293 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C2VYW9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 LOC102030124  cholesterol 24-hydroxylase    cholesterol 24-hydroxylase-like  Symbol and/or name change 5135510 APPROVED