Hsd17b1 (hydroxysteroid 17-beta dehydrogenase 1)

Gene: Hsd17b1 (hydroxysteroid 17-beta dehydrogenase 1) Chinchilla lanigera

Analyze

Symbol:

Hsd17b1

Name:

hydroxysteroid 17-beta dehydrogenase 1

RGD ID:

9005725

Description:

ENCODES a protein that exhibits 17-beta-hydroxysteroid dehydrogenase (NADP+) activity (ortholog); estradiol 17-beta-dehydrogenase [NAD(P)] activity (ortholog); estradiol binding (ortholog); INVOLVED IN adipose tissue development (ortholog); bone development (ortholog); cellular response to metal ion (ortholog); PARTICIPATES IN estradiol biosynthetic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); endometriosis (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

estradiol 17-beta-dehydrogenase 1; hydroxysteroid (17-beta) dehydrogenase 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	16,449,683 - 16,451,945 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	16,449,333 - 16,452,036 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

endometriosis (ISO)

genetic disease (ISO)

invasive ductal carcinoma (ISO)

mucopolysaccharidosis type IIIB (ISO)

Prostatic Neoplasms (ISO)

Spontaneous Abortions (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adipose tissue development (ISO)

bone development (ISO)

cellular response to metal ion (ISO)

estrogen biosynthetic process (ISO)

gene expression (ISO)

lipid metabolic process (ISO)

lysosome organization (ISO)

skeletal muscle tissue development (ISO)

testosterone biosynthetic process (ISO)

Cellular Component

cytosol (ISO)

Molecular Function

17-beta-hydroxysteroid dehydrogenase (NADP+) activity (ISO)

estradiol 17-beta-dehydrogenase [NAD(P)] activity (ISO)

estradiol binding (ISO)

NADP binding (ISO)

NADP+ binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

small molecule binding (ISO)

steroid binding (ISO)

testosterone dehydrogenase (NAD+) activity (ISO)

testosterone dehydrogenase [NAD(P)] activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

estradiol biosynthetic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Hsd17b1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	16,449,683 - 16,451,945 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	16,449,333 - 16,452,036 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSD17B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	42,552,923 - 42,555,214 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	42,552,922 - 42,555,214 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	40,704,941 - 40,707,232 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	37,957,510 - 37,960,757 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	37,957,509 - 37,960,757	NCBI
Celera	17	37,359,920 - 37,363,168 (+)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	36,468,996 - 36,472,244 (+)	NCBI		HuRef
CHM1_1	17	40,939,828 - 40,943,076 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	43,410,112 - 43,412,403 (+)	NCBI		T2T-CHM13v2.0

Hsd17b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	100,968,792 - 100,972,014 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	100,969,237 - 100,971,353 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	101,077,968 - 101,081,188 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	101,078,411 - 101,080,527 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	100,939,725 - 100,941,819 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	100,894,501 - 100,896,595 (+)	NCBI		MGSCv36	mm8
Celera	11	112,374,513 - 112,376,607 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	64.17	NCBI

Hsd17b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	86,510,011 - 86,512,211 (+)	NCBI		GRCr8
mRatBN7.2	10	86,009,728 - 86,011,928 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	86,009,728 - 86,011,927 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	91,046,170 - 91,048,370 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,524,986 - 90,527,186 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	85,918,153 - 85,920,353 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	88,987,558 - 88,989,758 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	88,987,558 - 88,989,757 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	88,786,054 - 88,788,254 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	90,094,249 - 90,096,451 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	90,108,618 - 90,110,820 (+)	NCBI
Celera	10	84,727,443 - 84,729,643 (+)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

HSD17B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	22,429,368 - 22,431,647 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	24,319,367 - 24,325,778 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	14,760,856 - 14,763,584 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	14,986,538 - 14,989,741 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	14,986,814 - 14,988,820 (-)	Ensembl	panpan1.1		panPan2

HSD17B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,402,124 - 20,407,143 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	20,405,019 - 20,406,792 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	19,866,871 - 19,868,985 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	21,123,971 - 21,126,087 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	21,123,971 - 21,125,745 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	19,909,803 - 19,911,916 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	20,175,037 - 20,177,147 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,279,091 - 20,281,208 (-)	NCBI		UU_Cfam_GSD_1.0

Hsd17b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	19,760,718 - 19,762,826 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	17,312,390 - 17,314,409 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	17,312,390 - 17,314,423 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD17B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	20,269,056 - 20,271,548 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	20,269,468 - 20,271,349 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	20,482,373 - 20,484,253 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSD17B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	63,730,303 - 63,733,974 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	63,728,777 - 63,732,411 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	34,525,962 - 34,529,030 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsd17b1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	1,551,311 - 1,553,493 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	1,551,311 - 1,553,432 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005394464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01043677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01043678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01028037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000023737 ⟹ ENSCLAP00000023514

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955451	16,449,683 - 16,451,945 (+)	Ensembl

RefSeq Acc Id:

XM_005394464 ⟹ XP_005394521

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955451	16,449,333 - 16,452,036 (+)	NCBI

Sequence:

show sequence

GTTTCCCCATTTTTGATACTAACGCTCGGCGTTTGAACAGAGTGGCCTTTCACAGCACGGCAGA
AAACCCTGGTGGCCGTCACTGCGGTTCAGGACGGAGACGCCCAGGAGCTGGGTGCGCAGCGTCC
CCGCGGGACCCCACACTCCGGGCAAGGCCACCTGCACCCCGGACACCCGAGGTTACAGTCACGG
GCTTCTCGACTTTGACGCAGAGCAGGGGGGCGGCCCTGACCGGCCGGGGAGGTTTGGCCTTGAG
ATCTGAGTAGACTCCACAAGGGCTGGGGGCGCGGCGGGGCGGGGCAGCCGCTCGGATATCAGGG
GTGCCGCCGGCGGGGCCCCAGCCCTGCAGCATGGACCCCGCCGAGCGCACCGTGGTGCTCATCA
CCGGCTGCTCCTCCGGCATCGGCCTGCGCCTGGCCGTCCGCCTGGCCGCGGACCCGTCCGGGAA
CTTCAAAGTGTACGCTACCATGCGGGACCTGGCGGCGCAGGGAGCGCTGTGGGAGGCGGCCCGG
GCCCGGCGCTGCCCGCCCGGGGCCCTGGAAGCGCTGCAGCTGGACGTGAGGGACTCGGACTCGG
TGGCCGCTGCCCGGGCACGCGTGATCGAGGGCCGCGTGGATCCCCCAGTGTGCAACGCGGGCCG
CGGGCTGCTCGGGCCGCTGGAGGCGCACGAGCTGGGCGCCGTGGGCTCTGTGCTGGACGTGAAC
GTGGTCGGGACCGTGCGGACGGTCCAGGCCTTCCTGCCGGACATGAAGCGGCGCGGCTCGGGCC
GCGTGCTGGTGACCGGGAGCGTGGGCGGCCTGATGGGGTTGCCTTTCAACGCCATCTACTGTGC
CAGCAAGTTCGCGCTCGAGGGTTTGTGCGAGAGCCTGGCGGTCTTGCTGCTGCCCTTCGGGGTC
CACGTAAGCCTCATCGAGTGCGGCCCGGTGCACACCGCCTTCTACGAGAAGCTGGAGGGCGGCC
TGGGCGGGGCGCTGGACCGCACGGACGCCCGCACGCGCCAGCTCTTCTCGCTGTACCAGCGCCA
CTGCGAGCAGGTGGCGCGCGAGGCGCAGGACCCGGAGGAGGTGGCGGAGGTCTTCCTGGCCGCC
CTGCGCGCCCCGCAGCCCGCCCTGCGCTACTTCTGCACAGAGCGCTTCCTGCCTCTCGCGCGCC
TGCGCGTGGAGGACCCGAGCGGCCGCAGCTACGTGGCCGCCATGCACCGCGCGGTGTTCGCCGC
CGACCCCGGGGCCGCGGAGCCGGGCGCCGCCCCCGGGGAAGGCTGCGCGCGCCTCTGATGGATC
TCCAGTGTGGTCTGGCTGCCGGGCTGCCGCGAGGCCTGAGATAATAAAGCCGCAGTTACTGTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005394521	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000023514
	ENSCLAP00000023514.1

RefSeq Acc Id:

XP_005394521 ⟸ XM_005394464

- UniProtKB:

A0A8C2W1B8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPAERTVVLITGCSSGIGLRLAVRLAADPSGNFKVYATMRDLAAQGALWEAARARRCPPGALE
ALQLDVRDSDSVAAARARVIEGRVDPPVCNAGRGLLGPLEAHELGAVGSVLDVNVVGTVRTVQA
FLPDMKRRGSGRVLVTGSVGGLMGLPFNAIYCASKFALEGLCESLAVLLLPFGVHVSLIECGPV
HTAFYEKLEGGLGGALDRTDARTRQLFSLYQRHCEQVAREAQDPEEVAEVFLAALRAPQPALRY
FCTERFLPLARLRVEDPSGRSYVAAMHRAVFAADPGAAEPGAAPGEGCARL

hide sequence

RefSeq Acc Id:

ENSCLAP00000023514 ⟸ ENSCLAT00000023737

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000016130	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023737	ENTREZGENE
	ENSCLAT00000023737.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	17beta_DH	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	Hsd17b1	ENTREZGENE
PANTHER	17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1	UniProtKB/TrEMBL
	RETINOL DEHYDROGENASE-RELATED	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
PIRSF	17beta-HSD	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8C2W1B8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Hsd17b1	hydroxysteroid 17-beta dehydrogenase 1		hydroxysteroid (17-beta) dehydrogenase 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations