Lgr5 (leucine rich repeat containing G protein-coupled receptor 5) - Rat Genome Database

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Gene: Lgr5 (leucine rich repeat containing G protein-coupled receptor 5) Chinchilla lanigera
Analyze
Symbol: Lgr5
Name: leucine rich repeat containing G protein-coupled receptor 5
RGD ID: 9005705
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); transmembrane signaling receptor activity (ortholog); INVOLVED IN epithelial cell proliferation involved in renal tubule morphogenesis (ortholog); hair follicle development (ortholog); inner ear development (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH ankyloglossia (ortholog); Colonic Neoplasms (ortholog); Colorectal Neoplasms (ortholog); FOUND IN Golgi apparatus (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,507,083 - 11,574,569 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540511,507,083 - 11,574,504 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Lgr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,507,083 - 11,574,569 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540511,507,083 - 11,574,504 (+)NCBIChiLan1.0ChiLan1.0
LGR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381271,439,129 - 71,586,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1271,439,798 - 71,586,310 (+)EnsemblGRCh38hg38GRCh38
GRCh371271,833,578 - 71,980,090 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,120,080 - 70,264,889 (+)NCBINCBI36Build 36hg18NCBI36
Celera1271,496,570 - 71,640,955 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1268,883,082 - 69,029,217 (+)NCBIHuRef
CHM1_11271,801,182 - 71,947,319 (+)NCBICHM1_1
T2T-CHM13v2.01271,416,272 - 71,563,815 (+)NCBIT2T-CHM13v2.0
Lgr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,286,219 - 115,423,685 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10115,286,216 - 115,423,685 (-)EnsemblGRCm39 Ensembl
GRCm3810115,450,314 - 115,587,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,450,311 - 115,587,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710114,887,370 - 115,024,836 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610114,855,736 - 114,991,603 (-)NCBIMGSCv36mm8
Celera10117,380,191 - 117,518,061 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
Lgr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8752,973,151 - 53,107,964 (-)NCBIGRCr8
mRatBN7.2751,087,059 - 51,221,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,088,239 - 51,222,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx752,995,022 - 53,128,661 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,198,103 - 55,331,742 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,976,093 - 55,109,728 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,447,097 - 58,587,787 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,448,277 - 58,587,787 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,458,486 - 58,596,253 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4754,737,745 - 54,876,664 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1754,758,873 - 54,897,394 (-)NCBI
Celera747,880,362 - 48,010,031 (-)NCBICelera
Cytogenetic Map7q22NCBI
LGR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21079,468,978 - 79,616,542 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11279,465,378 - 79,612,941 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01268,963,423 - 69,110,107 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11271,823,622 - 71,969,712 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1271,823,511 - 71,969,704 (+)Ensemblpanpan1.1panPan2
LGR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11013,009,028 - 13,136,685 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1013,007,843 - 13,136,998 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1012,948,043 - 13,075,055 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01013,142,096 - 13,269,246 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,141,905 - 13,269,846 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,007,284 - 13,134,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,254,327 - 13,381,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,378,129 - 13,505,269 (+)NCBIUU_Cfam_GSD_1.0
Lgr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494545,064,817 - 45,197,890 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936568530,188 - 663,520 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936568530,314 - 662,524 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl535,463,279 - 35,595,930 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1535,463,257 - 35,595,234 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2538,217,567 - 38,297,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,054,004 - 67,202,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1167,141,531 - 67,202,547 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037178,451,865 - 178,599,246 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475026,186,733 - 26,358,043 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475026,185,196 - 26,302,717 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000010567   ⟹   ENSCLAP00000010436
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540511,507,083 - 11,574,569 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000010568   ⟹   ENSCLAP00000010437
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540511,507,088 - 11,574,569 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000010569   ⟹   ENSCLAP00000010438
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540511,507,152 - 11,572,960 (+)Ensembl
RefSeq Acc Id: XM_005374681   ⟹   XP_005374738
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540511,507,083 - 11,574,504 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005374738 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000010436
  ENSCLAP00000010436.1
  ENSCLAP00000010437.1
  ENSCLAP00000010438.1
RefSeq Acc Id: XP_005374738   ⟸   XM_005374681
- UniProtKB: A0A8C2VA68 (UniProtKB/TrEMBL),   A0A8C2V553 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000010437   ⟸   ENSCLAT00000010568
RefSeq Acc Id: ENSCLAP00000010438   ⟸   ENSCLAT00000010569
RefSeq Acc Id: ENSCLAP00000010436   ⟸   ENSCLAT00000010567

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000007212 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000010567 ENTREZGENE
  ENSCLAT00000010567.1 UniProtKB/TrEMBL
  ENSCLAT00000010568.1 UniProtKB/TrEMBL
  ENSCLAT00000010569.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Gphrmn_rcpt_fam UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
NCBI Gene Lgr5 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PRINTS GLYCHORMONER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
  L domain-like UniProtKB/TrEMBL
UniProt A0A8C2V553 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2V574_CHILA UniProtKB/TrEMBL
  A0A8C2VA68 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Lgr5  leucine rich repeat containing G protein-coupled receptor 5    leucine-rich repeat containing G protein-coupled receptor 5  Symbol and/or name change 5135510 APPROVED