Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase) - Rat Genome Database

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Gene: Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase) Chinchilla lanigera
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Symbol: Hmgcl
Name: 3-hydroxy-3-methylglutaryl-CoA lyase
RGD ID: 9004045
Description: ENCODES a protein that exhibits carboxylic acid binding (ortholog); fatty-acyl-CoA binding (ortholog); hydroxymethylglutaryl-CoA lyase activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); ketone body biosynthetic process (ortholog); lipid metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); amino acid metabolic disorder (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrion (ortholog); peroxisome (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 3-hydroxymethyl-3-methylglutaryl-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,720,103 - 3,735,192 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,720,103 - 3,734,730 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References


Genomics

Comparative Map Data
Hmgcl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,720,103 - 3,735,192 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,720,103 - 3,734,730 (-)NCBIChiLan1.0ChiLan1.0
HMGCL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl123,801,885 - 23,838,620 (-)EnsemblGRCh38hg38GRCh38
GRCh38123,801,885 - 23,825,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37124,128,375 - 24,151,919 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,000,954 - 24,024,536 (-)NCBINCBI36hg18NCBI36
Build 34123,873,682 - 23,897,218NCBI
Celera122,457,935 - 22,481,518 (-)NCBI
Cytogenetic Map1p36.11NCBI
HuRef122,379,944 - 22,403,530 (-)NCBIHuRef
CHM1_1124,241,156 - 24,264,719 (-)NCBICHM1_1
Hmgcl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,673,745 - 135,689,979 (+)NCBIGRCm39mm39
GRCm39 Ensembl4135,673,759 - 135,689,928 (+)Ensembl
GRCm384135,946,448 - 135,962,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,946,448 - 135,962,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv374135,502,368 - 135,518,532 (+)NCBIGRCm37mm9NCBIm37
MGSCv364135,218,521 - 135,234,689 (+)NCBImm8
Celera4134,147,609 - 134,163,748 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.14NCBI
Hmgcl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25148,178,203 - 148,192,072 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5148,178,252 - 148,192,068 (+)Ensembl
Rnor_6.05154,294,841 - 154,308,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,294,806 - 154,308,640 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,059,692 - 158,073,433 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,730,232 - 154,743,974 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15154,740,270 - 154,754,013 (+)NCBI
Celera5146,585,153 - 146,598,872 (+)NCBICelera
Cytogenetic Map5q36NCBI
HMGCL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1123,977,723 - 24,016,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,977,723 - 24,001,150 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0122,993,489 - 23,017,307 (-)NCBIMhudiblu_PPA_v0panPan3
HMGCL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,688,736 - 75,703,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,688,827 - 75,702,965 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,258,838 - 72,273,447 (+)NCBI
ROS_Cfam_1.0276,248,035 - 76,262,645 (+)NCBI
UMICH_Zoey_3.1273,070,389 - 73,084,998 (+)NCBI
UNSW_CanFamBas_1.0274,077,019 - 74,091,642 (+)NCBI
UU_Cfam_GSD_1.0275,082,631 - 75,097,245 (+)NCBI
Hmgcl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,130,437 - 43,146,341 (-)NCBI
SpeTri2.0NW_0049364748,955,216 - 8,971,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGCL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,611,422 - 81,630,530 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1681,611,516 - 81,630,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,396,399 - 75,415,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGCL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,846,313 - 108,883,702 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20108,860,613 - 108,884,473 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660337,451,331 - 7,475,377 (-)NCBIVero_WHO_p1.0
Hmgcl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247648,349,288 - 8,363,178 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000020577   ⟹   ENSCLAP00000020381
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554523,720,103 - 3,735,192 (-)Ensembl
RefSeq Acc Id: XM_005394773   ⟹   XP_005394830
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554523,720,103 - 3,734,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005394774   ⟹   XP_005394831
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554523,720,103 - 3,734,730 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005394830 (Get FASTA)   NCBI Sequence Viewer  
  XP_005394831 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005394831   ⟸   XM_005394774
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005394830   ⟸   XM_005394773
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000020381   ⟸   ENSCLAT00000020577


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013961 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000020381 ENTREZGENE
Ensembl Transcript ENSCLAT00000020577 ENTREZGENE
NCBI Gene Hmgcl ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 Hmgcl  3-hydroxy-3-methylglutaryl-CoA lyase    3-hydroxymethyl-3-methylglutaryl-CoA lyase  Symbol and/or name change 5135510 APPROVED