Txndc15 (thioredoxin domain containing 15)

Gene: Txndc15 (thioredoxin domain containing 15) Chinchilla lanigera

Analyze

Symbol:

Txndc15

Name:

thioredoxin domain containing 15

RGD ID:

9003796

Description:

INVOLVED IN cilium assembly (ortholog); positive regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cilium (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

thioredoxin domain-containing protein 15

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	30,067,557 - 30,086,705 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	30,067,455 - 30,087,095 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Meckel syndrome (ISO)

Meckel Syndrome 14 (ISO)

Neurodevelopmental Disorders (ISO)

severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cilium assembly (ISO)

positive regulation of smoothened signaling pathway (ISO)

Cellular Component

cilium (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Txndc15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	30,067,557 - 30,086,705 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	30,067,455 - 30,087,095 (+)	NCBI	ChiLan1.0	ChiLan1.0

TXNDC15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	134,873,770 - 134,901,635 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	134,874,371 - 134,901,635 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	134,209,460 - 134,237,325 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	134,237,359 - 134,265,222 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	134,237,325 - 134,264,851	NCBI
Celera	5	130,337,761 - 130,365,637 (+)	NCBI		Celera
Cytogenetic Map	5	q31.1	NCBI
HuRef	5	129,395,781 - 129,423,417 (+)	NCBI		HuRef
CHM1_1	5	133,642,093 - 133,669,957 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	135,400,718 - 135,428,599 (+)	NCBI		T2T-CHM13v2.0

Txndc15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	55,862,463 - 55,874,040 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	55,862,463 - 55,874,040 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	55,714,650 - 55,726,227 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	55,714,650 - 55,726,227 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	55,816,011 - 55,827,588 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	55,724,272 - 55,735,849 (+)	NCBI		MGSCv36	mm8
Celera	13	56,769,512 - 56,781,103 (+)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	30.06	NCBI

Txndc15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	8,903,248 - 8,915,714 (-)	NCBI		GRCr8
mRatBN7.2	17	8,898,074 - 8,910,538 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	8,845,084 - 8,910,539 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	8,913,869 - 8,925,925 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,443,457 - 10,455,502 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	8,910,250 - 8,922,309 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,429,171 - 9,441,628 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,429,175 - 9,441,526 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	11,542,064 - 11,548,898 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	17	11,147,137 - 11,170,340 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	14,938,295 - 14,950,842 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	14,938,294 - 14,950,842 (-)	NCBI
Celera	17	8,979,947 - 8,992,303 (-)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

TXNDC15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	130,170,848 - 130,199,386 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	128,310,403 - 128,338,946 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	130,275,685 - 130,301,164 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	136,417,859 - 136,443,185 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	136,417,859 - 136,443,185 (+)	Ensembl	panpan1.1		panPan2

TXNDC15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	22,943,965 - 22,958,851 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	22,943,965 - 22,958,578 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	21,693,258 - 21,707,981 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	23,750,611 - 23,765,338 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	23,750,611 - 23,765,329 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	22,449,855 - 22,464,577 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	22,315,788 - 22,330,510 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	22,958,072 - 22,972,731 (+)	NCBI		UU_Cfam_GSD_1.0

Txndc15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	123,072,719 - 123,087,240 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	2,097,627 - 2,112,348 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	2,097,535 - 2,112,144 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TXNDC15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	137,060,893 - 137,080,106 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	137,060,988 - 137,079,288 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	142,677,073 - 142,695,376 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TXNDC15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	37,660,396 - 37,685,014 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	37,660,913 - 37,685,032 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	40,232,413 - 40,257,037 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Txndc15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	12,165,445 - 12,182,691 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	12,164,922 - 12,182,847 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005376469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01008794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01008795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01192967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000020414 ⟹ ENSCLAP00000020218

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955408	30,067,557 - 30,086,705 (+)	Ensembl

RefSeq Acc Id:

XM_005376469 ⟹ XP_005376526

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955408	30,067,455 - 30,087,095 (+)	NCBI

Sequence:

show sequence

CCCCAATTTCCCTCGGGCAGTGAGCGCGACTCTCTTTGCTTAACCCGAACGCGGGCTGCTCTTC
TGCTGGGTGGTGGTCCGGGTCGACGCCCGCACCCTGCCATGCGGCTCCTCTGTAGGTGGCAGCT
GCTGCTGTGGGTGCTGGGGCTTCCTGCCCGCGGCCTAGAGGAGGACTGTGGGCATTTACGGCCG
GAGGAGCAGCCTGCCCCGCCTCTCCAGGAGGGGACCGCGTCCCTGGATGAGGAGGCGACCCCGT
GGGATCCAAGCAGCCGCGGCCGCCGGGAGAGGGCGGCAGAAGAGGCTGACGCTGCGCAGGGGCG
GGGCACTCCCGGGGACCCCATGGTGGTGCTGTCTGTGATACCCGGAGAAGCCGAGGACAGACGG
AGCTCAGAGCCCAGCAGCGGCACGTGCGCTGCTGCAGGAGAGGAGGACGCGGGGTGCAGTGTCC
GCGACAGCCTCCTCTCCCGGGCCAGCGCGGGGCCGGCCTTCGCGGACCGAGAGGAGGACGACGA
CCCCGAGCCGGAAGCGGAGGCGGACGCGGCCGACCCCTCCCCGGCGGAGGACTCCAACAACACC
GAGAGCCTCAAGTCCCCGAAGGTGAACTGTGAGGAGAGGAATGTGACGGCGCTGGAGAACTTCA
CTCTGAAAATTTTAAATATGTCCCAGGACCTTATGGATTTCCTAAACCCAAACGGTAGTGACTG
TACCCTGGTCCTGTTCTACACCCCCTGGTGCCGATTTTCTGCCAGTTTGGCCCCTCATTTTAAC
TCGCTGCCCCGGGCATTTCCAGCTCTTCATTTTTTGGCTCTGGATGCATCTCAGCACAGCAGCC
TTTCCACCAGGTTTGGTACTGTAGCTGTTCCTAACATCTTGTTATTTCAAGGAGCTAAACCAAT
GGCTAGATTTAATCATACAGATCGAACACTGGAAACGCTGAAAATCTTCATTTATAATCAGACA
GGTATAGAAGCCAAGAAAAATGTGGTGGTAACTCAAGCTGATCAAATAGGCCCTCTTCCCAGCA
CTCTGATAAAAAGTGTGGACTGGTTGCTTGTATTTTCCTTATTCTTTTTAATTAGCTTTATTAT
GTATGCTACCATTCGAACTGAGAGCATTCGGTGGCTAATTCCAGGACAAGAACAGGAACATGCA
GAATAGTGATGGACCAAAAGGAGAAGTTGGAAAGAGAAGCAATTTCAATATTTCATTTCGGAAA
TTAGTGCTACAATCTCATGCATTTTCTCCAGTGAAGTGCTCACCTGCAACTTCAGCCATTTAAG
GGAATCATGCATTTGCTGACTACTGAACAGGTTAAAAAAATTATAAACTGGTGTTTTAACTAGT
ACTGTAATAAGCAAATGCAAAAATATTAAAATTGAGAATTTTTACTACTTGCACATAACCTAGT
ATTTTAAGAGTAATCCAGTTTGAAATGTGAACACACATTCTGGTAGAATTAGTGAACAGAATGA
CACTTGTTACTATACAGAAGGCAGAAACAGAACTTTGAGATGACAGTTTTAGAAAACTTTGGGT
TCCTTGTGTCTGTCTGTGAAGGTTGGTTTTGTTTGTTTGGAATTTCTCTTCCAGAGTTGCTGAG
CAGGAAAATGTTCTGTTACGGGAAGAATAACCAGAAATGTTAAGTGTGACCCTGTAAGTAATAA
CTGATGGAAAATAAAGTCAAATACCTTGGTGTTTGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005376526	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000020218
	ENSCLAP00000020218.1

RefSeq Acc Id:

XP_005376526 ⟸ XM_005376469

- UniProtKB:

A0A8C2VXD3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLLCRWQLLLWVLGLPARGLEEDCGHLRPEEQPAPPLQEGTASLDEEATPWDPSSRGRRERAA
EEADAAQGRGTPGDPMVVLSVIPGEAEDRRSSEPSSGTCAAAGEEDAGCSVRDSLLSRASAGPA
FADREEDDDPEPEAEADAADPSPAEDSNNTESLKSPKVNCEERNVTALENFTLKILNMSQDLMD
FLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNI
LLFQGAKPMARFNHTDRTLETLKIFIYNQTGIEAKKNVVVTQADQIGPLPSTLIKSVDWLLVFS
LFFLISFIMYATIRTESIRWLIPGQEQEHAE

hide sequence

RefSeq Acc Id:

ENSCLAP00000020218 ⟸ ENSCLAT00000020414

Protein Domains

Thioredoxin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013852	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000020414	ENTREZGENE
	ENSCLAT00000020414.1	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Thioredoxin-like_sf	UniProtKB/TrEMBL
	Thioredoxin_domain	UniProtKB/TrEMBL
	TXNDC15	UniProtKB/TrEMBL
NCBI Gene	Txndc15	ENTREZGENE
PANTHER	PTHR14684	UniProtKB/TrEMBL
	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15	UniProtKB/TrEMBL
Pfam	Thioredoxin	UniProtKB/TrEMBL
PROSITE	THIOREDOXIN_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52833	UniProtKB/TrEMBL
UniProt	A0A8C2VXD3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM