Mars1 (methionyl-tRNA synthetase 1) - Rat Genome Database

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Gene: Mars1 (methionyl-tRNA synthetase 1) Chinchilla lanigera
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Symbol: Mars1
Name: methionyl-tRNA synthetase 1
RGD ID: 8995447
Description: ENCODES a protein that exhibits methionine-tRNA ligase activity (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to platelet-derived growth factor stimulus (ortholog); methionyl-tRNA aminoacylation (ortholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease axonal type 2U (ortholog); familial melanoma (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Mars; methionine--tRNA ligase, cytoplasmic; methionyl-tRNA synthetase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,215,853 - 5,233,037 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,215,853 - 5,233,037 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,215,853 - 5,233,037 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,215,853 - 5,233,037 (+)NCBIChiLan1.0ChiLan1.0
MARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,488,068 - 57,516,652 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,475,445 - 57,517,569 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,881,851 - 57,910,435 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,168,118 - 56,196,700 (+)NCBINCBI36Build 36hg18NCBI36
Build 341256,168,117 - 56,196,700NCBI
Celera1257,535,658 - 57,566,266 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,919,857 - 54,948,436 (+)NCBIHuRef
CHM1_11257,849,852 - 57,878,293 (+)NCBICHM1_1
T2T-CHM13v2.01257,456,360 - 57,484,880 (+)NCBIT2T-CHM13v2.0
Mars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,132,090 - 127,147,655 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,132,090 - 127,147,655 (-)EnsemblGRCm39 Ensembl
GRCm3810127,296,221 - 127,311,786 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,296,221 - 127,311,786 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,733,277 - 126,748,842 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,699,175 - 126,714,588 (-)NCBIMGSCv36mm8
Celera10129,688,532 - 129,704,394 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Mars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,006,456 - 65,023,880 (-)NCBIGRCr8
mRatBN7.2763,121,142 - 63,138,550 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,121,142 - 63,138,495 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,010,415 - 65,027,712 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,212,835 - 67,230,132 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,014,183 - 67,031,462 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,585,011 - 70,602,425 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,585,013 - 70,602,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,759,159 - 70,776,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,252,510 - 67,269,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,273,245 - 67,290,584 (-)NCBI
Celera760,261,413 - 60,278,690 (-)NCBICelera
Cytogenetic Map7q22NCBI
MARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,824,464 - 36,863,833 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,821,235 - 36,848,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,410,231 - 31,438,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,668,634 - 31,693,988 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,668,708 - 31,693,839 (-)Ensemblpanpan1.1panPan2
MARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,588,503 - 1,606,752 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,588,875 - 1,606,750 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,651,747 - 1,669,984 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,597,550 - 1,615,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,597,894 - 1,615,814 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,575,609 - 1,593,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,817,102 - 1,835,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,942,478 - 1,960,709 (+)NCBIUU_Cfam_GSD_1.0
Mars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,205,154 - 57,225,738 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,644,457 - 1,665,086 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,644,457 - 1,665,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,752,374 - 22,785,501 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,752,405 - 22,785,509 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,397,380 - 53,410,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037192,539,409 - 192,566,135 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,443,223 - 10,460,971 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,443,216 - 10,460,971 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000017910   ⟹   ENSCLAP00000017735
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554585,215,853 - 5,233,037 (+)Ensembl
RefSeq Acc Id: XM_013520894   ⟹   XP_013376348
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554585,215,853 - 5,233,037 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013376348 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017735
  ENSCLAP00000017735.1
RefSeq Acc Id: XP_013376348   ⟸   XM_013520894
- UniProtKB: A0A8C2VPI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000017735   ⟸   ENSCLAT00000017910
Protein Domains
GST C-terminal   WHEP-TRS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017910 ENTREZGENE
  ENSCLAT00000017910.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  2.20.28.20 UniProtKB/TrEMBL
  3.40.50.620 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
  S15/NS1, RNA-binding UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  Anticodon_Met UniProtKB/TrEMBL
  Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  MARS_N UniProtKB/TrEMBL
  Met-tRNA_ligase_1 UniProtKB/TrEMBL
  Met-tRNA_synth UniProtKB/TrEMBL
  Methionyl/Leucyl_tRNA_Synth UniProtKB/TrEMBL
  MetRS_core UniProtKB/TrEMBL
  MetRS_Zn UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  S15_NS1_RNA-bd UniProtKB/TrEMBL
  tRNAsynth_Ia_anticodon-bd UniProtKB/TrEMBL
  WHEP-TRS_dom UniProtKB/TrEMBL
NCBI Gene Mars ENTREZGENE
PANTHER METHIONINE--TRNA LIGASE, CYTOPLASMIC UniProtKB/TrEMBL
  PTHR45765 UniProtKB/TrEMBL
Pfam Anticodon_3 UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  GST_N_5 UniProtKB/TrEMBL
  tRNA-synt_1g UniProtKB/TrEMBL
  WHEP-TRS UniProtKB/TrEMBL
PRINTS TRNASYNTHMET UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
  GST_CTER UniProtKB/TrEMBL
  WHEP_TRS_1 UniProtKB/TrEMBL
  WHEP_TRS_2 UniProtKB/TrEMBL
SMART WHEP-TRS UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF47060 UniProtKB/TrEMBL
  SSF47323 UniProtKB/TrEMBL
  SSF47616 UniProtKB/TrEMBL
  SSF57770 UniProtKB/TrEMBL
UniProt A0A8C2VPI6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 Mars1  methionyl-tRNA synthetase 1  Mars  methionyl-tRNA synthetase  Symbol and/or name change 5135510 APPROVED