Als2 (alsin Rho guanine nucleotide exchange factor ALS2) - Rat Genome Database
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Gene: Als2 (alsin Rho guanine nucleotide exchange factor ALS2) Chinchilla lanigera
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Symbol: Als2
Name: alsin Rho guanine nucleotide exchange factor ALS2
RGD ID: 8994196
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN axonogenesis (ortholog); behavioral fear response (ortholog); cell death (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Amyotrophic Lateral Sclerosis, Autosomal Recessive (ortholog); axonal neuropathy (ortholog); FOUND IN axon (ortholog); centrosome (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ALS2, alsin Rho guanine nucleotide exchange factor; alsin; amyotrophic lateral sclerosis 2 (juvenile)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,449 - 104,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,449 - 104,577 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References


Genomics

Comparative Map Data
Als2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,449 - 104,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,449 - 104,577 (+)NCBIChiLan1.0ChiLan1.0
ALS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2201,700,267 - 201,780,956 (-)EnsemblGRCh38hg38GRCh38
GRCh382201,700,267 - 201,781,153 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,564,990 - 202,645,656 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372202,564,986 - 202,645,895 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,273,522 - 202,353,983 (-)NCBINCBI36hg18NCBI36
Build 342202,390,782 - 202,471,244NCBI
Celera2196,316,786 - 196,398,012 (-)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2194,413,010 - 194,494,230 (-)NCBIHuRef
CHM1_12202,571,473 - 202,652,371 (-)NCBICHM1_1
Als2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,201,915 - 59,276,390 (-)NCBIGRCm39mm39
GRCm38159,162,756 - 59,237,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,162,926 - 59,237,231 (-)EnsemblGRCm38mm10GRCm38
MGSCv37159,219,600 - 59,294,075 (-)NCBIGRCm37mm9NCBIm37
MGSCv36159,107,478 - 59,181,765 (-)NCBImm8
Celera159,678,988 - 59,753,541 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
Als2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,613,182 - 60,686,394 (-)NCBI
Rnor_6.0 Ensembl965,961,346 - 66,033,871 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0965,961,361 - 66,034,396 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0965,768,594 - 65,841,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,741,679 - 57,812,652 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1957,887,443 - 57,959,517 (-)NCBI
Celera958,052,438 - 58,123,222 (-)NCBICelera
Cytogenetic Map9q31NCBI
ALS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B207,108,952 - 207,189,681 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,108,952 - 207,189,623 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B88,954,167 - 89,034,764 (-)NCBIMhudiblu_PPA_v0panPan3
ALS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3710,756,515 - 10,812,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13710,755,595 - 10,825,073 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Als2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936726940,696 - 1,015,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,328,718 - 105,401,108 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,328,717 - 105,401,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11087,389,130 - 87,473,134 (-)NCBI
Als2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462489974,080 - 170,565 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000018119   ⟹   ENSCLAP00000017941
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540322,449 - 104,948 (+)Ensembl
RefSeq Acc Id: XM_005373184   ⟹   XP_005373241
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,449 - 104,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373185   ⟹   XP_005373242
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,449 - 104,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005373186   ⟹   XP_005373243
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,449 - 87,251 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013511695   ⟹   XP_013367149
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,449 - 66,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013511698   ⟹   XP_013367152
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540322,449 - 62,466 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005373241   ⟸   XM_005373184
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005373242   ⟸   XM_005373185
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005373243   ⟸   XM_005373186
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013367149   ⟸   XM_013511695
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013367152   ⟸   XM_013511698
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSCLAP00000017941   ⟸   ENSCLAT00000018119


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012306 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000017941 ENTREZGENE
Ensembl Transcript ENSCLAT00000018119 ENTREZGENE
NCBI Gene Als2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 Als2  alsin Rho guanine nucleotide exchange factor ALS2    ALS2, alsin Rho guanine nucleotide exchange factor  Symbol and/or name change 5135510 APPROVED
2016-08-16 Als2  ALS2, alsin Rho guanine nucleotide exchange factor    amyotrophic lateral sclerosis 2 (juvenile)  Symbol and/or name change 5135510 APPROVED