Spsb1 (splA/ryanodine receptor domain and SOCS box containing 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Spsb1 (splA/ryanodine receptor domain and SOCS box containing 1) Chinchilla lanigera
Analyze
Symbol: Spsb1 (Ensembl: H6PD)
Name: splA/ryanodine receptor domain and SOCS box containing 1
RGD ID: 8991919
Description: ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SPRY domain-containing SOCS box protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,022,306 - 4,115,077 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,022,307 - 4,061,111 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Spsb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,022,306 - 4,115,077 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,022,307 - 4,061,111 (-)NCBIChiLan1.0ChiLan1.0
SPSB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,292,894 - 9,369,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,292,894 - 9,369,532 (+)EnsemblGRCh38hg38GRCh38
GRCh3719,352,953 - 9,429,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,275,571 - 9,352,178 (+)NCBINCBI36Build 36hg18NCBI36
Celera18,462,669 - 8,539,361 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef18,547,970 - 8,579,365 (+)NCBIHuRef
CHM1_119,388,399 - 9,419,828 (+)NCBICHM1_1
T2T-CHM13v2.018,827,769 - 8,904,391 (+)NCBIT2T-CHM13v2.0
Spsb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,980,740 - 150,039,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,980,740 - 150,039,500 (-)EnsemblGRCm39 Ensembl
GRCm384149,896,283 - 149,955,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,896,283 - 149,955,043 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,270,392 - 149,329,115 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364148,740,083 - 148,798,806 (-)NCBIMGSCv36mm8
Celera4152,167,650 - 152,226,371 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map480.46NCBI
Spsb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,641,255 - 165,701,482 (-)NCBIGRCr8
mRatBN7.25160,358,292 - 160,418,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,358,308 - 160,418,468 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,076,400 - 163,087,774 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,898,077 - 164,909,555 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,854,450 - 164,865,926 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05166,913,734 - 166,978,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,913,735 - 166,926,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,555,623 - 170,619,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,014,271 - 167,025,579 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,022,865 - 167,035,827 (-)NCBI
Celera5158,623,982 - 158,634,651 (-)NCBICelera
Cytogenetic Map5q36NCBI
SPSB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21218,856,729 - 218,935,323 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,504,077 - 217,580,356 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v018,053,596 - 8,132,143 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119,349,825 - 9,363,624 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19,349,825 - 9,363,624 (+)Ensemblpanpan1.1panPan2
SPSB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,640,420 - 62,669,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,639,629 - 62,667,790 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,616,269 - 62,685,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0562,825,418 - 62,894,575 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,825,374 - 62,894,572 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,824,606 - 62,892,430 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0562,687,237 - 62,756,451 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0563,091,729 - 63,160,856 (+)NCBIUU_Cfam_GSD_1.0
Spsb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,918,113 - 32,970,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,427,761 - 3,455,670 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366233,448,787 - 3,455,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPSB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,720,806 - 69,791,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,720,538 - 69,789,566 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPSB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,398,856 - 122,474,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,396,931 - 122,474,190 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605426,413,485 - 26,489,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spsb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248182,964,984 - 2,983,433 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248182,965,222 - 3,014,544 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009464   ⟹   ENSCLAP00000009335
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554864,022,306 - 4,115,077 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000009465   ⟹   ENSCLAP00000009336
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554864,022,306 - 4,061,349 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000009466   ⟹   ENSCLAP00000009337
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554864,022,306 - 4,032,364 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000009467   ⟹   ENSCLAP00000009338
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554864,086,999 - 4,115,077 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000009468   ⟹   ENSCLAP00000009339
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554864,086,999 - 4,105,245 (-)Ensembl
RefSeq Acc Id: XM_005404039   ⟹   XP_005404096
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,022,307 - 4,031,578 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404040   ⟹   XP_005404097
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,022,307 - 4,041,910 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404041   ⟹   XP_005404098
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,022,307 - 4,042,056 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404042   ⟹   XP_005404099
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,022,307 - 4,061,111 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005404099   ⟸   XM_005404042
- UniProtKB: A0A8C2YME1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005404098   ⟸   XM_005404041
- UniProtKB: A0A8C2YME1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005404097   ⟸   XM_005404040
- UniProtKB: A0A8C2YME1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005404096   ⟸   XM_005404039
- UniProtKB: A0A8C2YME1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000009335   ⟸   ENSCLAT00000009464
RefSeq Acc Id: ENSCLAP00000009336   ⟸   ENSCLAT00000009465
RefSeq Acc Id: ENSCLAP00000009337   ⟸   ENSCLAT00000009466
RefSeq Acc Id: ENSCLAP00000009338   ⟸   ENSCLAT00000009467
RefSeq Acc Id: ENSCLAP00000009339   ⟸   ENSCLAT00000009468
Protein Domains
B30.2/SPRY   SOCS box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006486 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009464.1 UniProtKB/TrEMBL
  ENSCLAT00000009465.1 UniProtKB/TrEMBL
  ENSCLAT00000009466 ENTREZGENE
  ENSCLAT00000009466.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  G6P_DH UniProtKB/TrEMBL
  G6P_DH_AS UniProtKB/TrEMBL
  G6P_DH_NAD-bd UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
NCBI Gene LOC102022195 ENTREZGENE
PANTHER SPRY DOMAIN CONTAINING SOCS BOX PROTEIN UniProtKB/TrEMBL
  SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1 UniProtKB/TrEMBL
Pfam G6PD_N UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
PRINTS G6PDHDRGNASE UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  G6P_DEHYDROGENASE UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
SMART SOCS_box UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8C2V2Y3_CHILA UniProtKB/TrEMBL
  A0A8C2YME1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YME4_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Spsb1  splA/ryanodine receptor domain and SOCS box containing 1  LOC102022195  SPRY domain-containing SOCS box protein 1-like  Symbol and/or name change 5135510 APPROVED