Cdt1 (chromatin licensing and DNA replication factor 1)

Gene: Cdt1 (chromatin licensing and DNA replication factor 1) Chinchilla lanigera

Analyze

Symbol:

Cdt1

Name:

chromatin licensing and DNA replication factor 1

RGD ID:

8991322

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN attachment of mitotic spindle microtubules to kinetochore (ortholog); DNA replication checkpoint signaling (ortholog); DNA replication preinitiation complex assembly (ortholog); ASSOCIATED WITH 16Q24.3 Microdeletion Syndrome (ortholog); adenine phosphoribosyltransferase deficiency (ortholog); autosomal recessive chronic granulomatous disease 4 (ortholog); FOUND IN kinetochore (ortholog); nuclear body (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA replication factor Cdt1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	2,683,408 - 2,687,102 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	2,683,030 - 2,687,883 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

16Q24.3 Microdeletion Syndrome (ISO)

adenine phosphoribosyltransferase deficiency (ISO)

autosomal recessive chronic granulomatous disease 4 (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

KBG syndrome (ISO)

Meier-Gorlin syndrome (ISO)

Meier-Gorlin syndrome 4 (ISO)

mucopolysaccharidosis IVA (ISO)

primary ciliary dyskinesia 33 (ISO)

Triple Negative Breast Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of mitotic spindle microtubules to kinetochore (ISO)

DNA replication checkpoint signaling (ISO)

DNA replication preinitiation complex assembly (ISO)

negative regulation of cell cycle (ISO)

negative regulation of DNA-templated DNA replication (ISO)

positive regulation of DNA replication (ISO)

positive regulation of DNA-templated DNA replication (ISO)

regulation of DNA-templated DNA replication initiation (ISO)

regulation of nuclear cell cycle DNA replication (ISO)

response to sorbitol (ISO)

Cellular Component

kinetochore (ISO)

nuclear body (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

chromatin binding (ISO)

DNA binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cdt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	2,683,408 - 2,687,102 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	2,683,030 - 2,687,883 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	88,803,789 - 88,809,258 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	88,803,789 - 88,809,258 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	88,870,197 - 88,875,666 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	87,397,687 - 87,403,167 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	73,938,823 - 73,944,303 (+)	NCBI		Celera
Cytogenetic Map	16	q24.3	NCBI
HuRef	16	74,567,412 - 74,572,892 (+)	NCBI		HuRef
CHM1_1	16	90,281,453 - 90,286,933 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	94,874,309 - 94,879,778 (+)	NCBI		T2T-CHM13v2.0

Cdt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	123,294,754 - 123,299,869 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	123,294,754 - 123,300,293 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	122,568,015 - 122,573,130 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	122,568,015 - 122,573,554 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	125,091,915 - 125,097,030 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	125,454,105 - 125,459,220 (+)	NCBI		MGSCv36	mm8
Celera	8	126,797,613 - 126,802,728 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	71.91	NCBI

Cdt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	67,529,249 - 67,534,195 (+)	NCBI		GRCr8
mRatBN7.2	19	50,620,713 - 50,625,659 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	50,620,713 - 50,625,659 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	57,415,480 - 57,420,429 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,095,635 - 58,100,581 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	60,314,104 - 60,319,053 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	55,381,565 - 55,386,511 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	55,381,565 - 55,386,511 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	66,090,081 - 66,095,027 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,848,559 - 52,853,880 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	52,852,915 - 52,858,234 (+)	NCBI
Celera	19	49,860,119 - 49,865,065 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

CDT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	98,576,543 - 98,582,287 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	104,488,752 - 104,494,459 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	69,516,728 - 69,522,419 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	89,173,312 - 89,178,809 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	89,174,071 - 89,177,823 (+)	Ensembl	panpan1.1		panPan2

CDT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	64,566,035 - 64,570,361 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	64,566,043 - 64,570,748 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	64,577,507 - 64,581,789 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	64,786,263 - 64,790,545 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	64,786,266 - 64,790,971 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	64,812,442 - 64,816,851 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	64,643,948 - 64,648,365 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	65,049,993 - 65,054,410 (-)	NCBI		UU_Cfam_GSD_1.0

Cdt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	25,163,147 - 25,172,972 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	917,435 - 920,981 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	916,695 - 925,411 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	893,381 - 897,934 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	893,377 - 897,706 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	1,083,762 - 1,089,922 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	74,190,409 - 74,196,589 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	74,190,947 - 74,195,972 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	1,482,389 - 1,488,114 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	809,252 - 812,993 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	808,463 - 813,464 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013508010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01071421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01071422	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01072853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01221086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000003210 ⟹ ENSCLAP00000003146

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955541	2,683,408 - 2,687,102 (+)	Ensembl

RefSeq Acc Id:

XM_013508010 ⟹ XP_013363464

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955541	2,683,030 - 2,687,883 (+)	NCBI

Sequence:

show sequence

CCCCAGCGTTCTTCCGGATGGTGCGTCCCGGATGGGGCGGAGCCGGTAGGAAACGGCGCGAAAA
CTGCGCGAAACGGCGCGAAACCGCGCGAAACCCCGCGTAGTCTGATCTCACTATGGCGCAGAGC
CGGGTCACCGATTTCTTCGCTTGCCGCCGCCCGGGGTCGGTAGCTCCGCAGGTCAAGGCAGCCT
GCCGCACCCCGAGCCCCACCGGGCCCTCGCCCGCCCTTGCCCCGGGCAGCAGCCGCAAGCGCGC
CCGCCCGCCTGCCGCGCCCGGGGGCGACCAGCCCGCGCCGCCCGCGCGCCGGAGACTGCGGCTG
CGGGACGCGGACTCCCTTCCCGGTTCCCCAGCCGCCCCCAGCTCCCCTACCTGTCATTCACTGG
CCAAGAAGGTCAAGAAAACCTCTGCCTCTGCCCCAGCCGGTCACCTGTCTCTCCTTGCAGCCCC
CCAGAACAAGGTCCCCTCGAAAGACGCTGTGCCCGAGCTCCAGGCATGCCTCCAGCGGGCGCGG
GAGCTGAGTGCACGTGTCCGGGCGCTGAAGGACAGGGCTCAGGAGGGTGCTGAGGAGCCCAGCC
CACCGGAGGCCGAGGGCCCTGAGAAGCGGCCACGCAGCGAGAAGGTGCCTGCCTACCAGCGCTT
CCATGCCTTGGCCCTGCCTGGCCTGCCAGGCCTTGTGCTGCCCTACAAGTACCAGGTGCTAGCT
GAGATGTTCCGCAGCATGGACACCATCGTGGGTATGCTCCACAACCGCTCCGAGACCGTGACCT
TTGCCAAGGTCAAGCGGGGGGTCCAGGACATGATGCGCAGGCGCTTTGAGGAGTACAACGTGGG
CCAGATCAAGACGGTGTACCCCATGTCCTACTGCTTCCGCCAGGAGCGCAACGTCCCCACCTTC
AAGGACAGTGTCAAGAAGTCTGATTACCAACTCACCATAGAGCCGCTGCTGGATGTGGAGGCTG
GTGGCACCACCCCTCAGCTCACAGCCTCGAGGTTGCTGCAGCGGCGCCAGGTCTTCAGCCAGAA
CCTGGTGGACCGGGTCAAGGAACACCACAAGGCCTTCCTGGCCTCCCTGAACCCCCCCATGGCT
GTGCCTGAGGACCAGCTGACACGCTGGCACCCACGCTTCAATGTGGACGAAGTGCCTGACATTG
AGCCAGCCGAGCTTCCCCAGCCGCCCACCGCGGAGAAGCTCACCACTGCCCAGGAGGTGCTGGC
CCGTGCCCGAAACCTGATGTCGCCCAGGATGGAAAAGGCCTTGAGTCACGCAGCTCTGTGTGCA
GCAGAGCCCCGCAGCCCTGGGTCCCCCAGCCCAGCACTGCCTGCCAGCCCGCCCACCATCCCTC
CCAGCGTGCTGAAGGGCGTGCCCCAGGCCCTGCTGGAGCGGATCCGTGCCAAAGAGGCCCAGAA
ACAGCTGGCACAAATGACACGGCGCCCGGAGCTTGAGCTGAGGCTGCAGCGACTGGAACGGTTG
CCTGAGCTGGCACGTGTGCTGCGTGGTGTCTTTGTGGCCGAGCGTAAGCCCGCACTCACCATGG
AGGTGGCCTGTGCCAGGATGGTGGGCAGCTGCCGAGCCACCCTGAGCCTGGGGGAGATGGAGAA
GCACCTGCTGCTCCTCGTTGAGCTGCTGCCTGACTGGCTCAGTTTGCACCGTATCCGCACCGAC
ACCTACATCAAGCTGGACAAAGCCGCCGACCTGGCCTCCATCACTGCACGGCTGGCCCGCCAGG
CCCGCACCGAGGAGGGGCAGTGAGCCCCGCTTTCACTCCTGTCACCAAAAGTCCCCGTCCCTGA
TGGCAACAGGCTTTGTGGCCTGAGCCTCCTGTCATGTGGGCTCCCAGGATCTCATGCAGTGTTG
GTGTTGCCTCTGCCCTGTGGGGCTCTGTCTTTGCTGCCTGACGGCCGTGCAGTCCTTCGGCACT
GCTGTGGGCAGGGAAGGGGCCCAGCGCCTGGTGGGCTGCACAGGAAGTGGTGTTGTGCAGAGCT
GGCAGTGTGGTTGGCAGTGTCCTCCCATCTGCGTCTTGGTGCTGAAGCGTGTGAATGGTGACCT
CGTGATGGGGGGCTGTTCTGATGTCCACCCACAGGCTTGCTGGGCATCTCCCCCATCACAGGCT
ACTTCAAGCCTGTTCTAGGTCCTGCCCAAGGCCAGAGCCAGGCTGAGTTCAGAGCATACCCAGA
GCTGCCTGCCTTGTACTCAAGAGATGCCTTCCTGTAAGACATGCCATGCCAGCAGGTAGTGTGG
GCCTCTGGGCACACCAGTGGATGAAAGATGAGGTTCCATGTGGCAGCATGAAGTCAGACTCTCT
AGAATGAAGAGAACTTCAGTTTTCTAGGTTTTGTGCTAAAATAATCTGTAGAACTTAAGGTGGG
ACTGTTTGCTTTGCTTACTTCTAGTTTAGCCTTTTCAAATATCTAAGGCCTTGGAAGGAGAACC
CATTTTGTAATCTTATTGGCTTTTTATAAAGTGAGTCATGTAAGATTTAAATAAAATTCACTCC
CGAGACTACTGCTTTGGAGTGCTGTTAACTGCTGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013363464	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000003146
	ENSCLAP00000003146.1

RefSeq Acc Id:

XP_013363464 ⟸ XM_013508010

- UniProtKB:

A0A8C2UNF0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQSRVTDFFACRRPGSVAPQVKAACRTPSPTGPSPALAPGSSRKRARPPAAPGGDQPAPPARR
RLRLRDADSLPGSPAAPSSPTCHSLAKKVKKTSASAPAGHLSLLAAPQNKVPSKDAVPELQACL
QRARELSARVRALKDRAQEGAEEPSPPEAEGPEKRPRSEKVPAYQRFHALALPGLPGLVLPYKY
QVLAEMFRSMDTIVGMLHNRSETVTFAKVKRGVQDMMRRRFEEYNVGQIKTVYPMSYCFRQERN
VPTFKDSVKKSDYQLTIEPLLDVEAGGTTPQLTASRLLQRRQVFSQNLVDRVKEHHKAFLASLN
PPMAVPEDQLTRWHPRFNVDEVPDIEPAELPQPPTAEKLTTAQEVLARARNLMSPRMEKALSHA
ALCAAEPRSPGSPSPALPASPPTIPPSVLKGVPQALLERIRAKEAQKQLAQMTRRPELELRLQR
LERLPELARVLRGVFVAERKPALTMEVACARMVGSCRATLSLGEMEKHLLLLVELLPDWLSLHR
IRTDTYIKLDKAADLASITARLARQARTEEGQ

hide sequence

RefSeq Acc Id:

ENSCLAP00000003146 ⟸ ENSCLAT00000003210

Protein Domains

CDT1 Geminin-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000002254	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000003210	ENTREZGENE
	ENSCLAT00000003210.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.1420	UniProtKB/TrEMBL
InterPro	Cdt1	UniProtKB/TrEMBL
	Cdt1_C	UniProtKB/TrEMBL
	Cdt1_C_WH_dom_sf	UniProtKB/TrEMBL
	CDT1_Gemini-bd-like	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Cdt1	ENTREZGENE
PANTHER	DNA REPLICATION FACTOR CDT1	UniProtKB/TrEMBL
	PTHR28637	UniProtKB/TrEMBL
Pfam	CDT1	UniProtKB/TrEMBL
	CDT1_C	UniProtKB/TrEMBL
SMART	CDT1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A0A8C2UNF0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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