Seh1l (SEH1 like nucleoporin) - Rat Genome Database

Name: Seh1l
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Seh1l (SEH1 like nucleoporin) Chinchilla lanigera

Analyze

Symbol:

Seh1l

Name:

SEH1 like nucleoporin

RGD ID:

8987617

Description:

INVOLVED IN attachment of mitotic spindle microtubules to kinetochore (ortholog); cellular response to amino acid starvation (ortholog); cellular response to nutrient levels (ortholog); PARTICIPATES IN mRNA nuclear export pathway; ASSOCIATED WITH chromosome 18p deletion syndrome (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN GATOR2 complex (ortholog); kinetochore (ortholog); lysosomal membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

nucleoporin SEH1; SEH1-like; SEH1-like nucleoporin

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SEH1L (SEH1 like nucleoporin)	NCBI	Ortholog
Mus musculus (house mouse):	Seh1l (SEH1-like (S. cerevisiae)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Seh1l (SEH1-like nucleoporin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SEH1L (SEH1 like nucleoporin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CEP192 (centrosomal protein 192)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Seh1l (SEH1 like nucleoporin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SEH1L (SEH1 like nucleoporin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Seh1l (SEH1 like nucleoporin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	681,436 - 698,624 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	679,109 - 698,624 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 18p deletion syndrome (ISO)

genetic disease (ISO)

intellectual disability (ISO)

tooth agenesis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of mitotic spindle microtubules to kinetochore (ISO)

cellular response to amino acid starvation (ISO)

cellular response to nutrient levels (ISO)

defense response to Gram-positive bacterium (ISO)

mitotic metaphase chromosome alignment (ISO)

nuclear pore organization (ISO)

positive regulation of TORC1 signaling (ISO)

protein-containing complex localization (ISO)

Cellular Component

GATOR2 complex (ISO)

kinetochore (ISO)

lysosomal membrane (ISO)

nuclear envelope (ISO)

nuclear pore outer ring (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mRNA nuclear export pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Seh1l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	681,436 - 698,624 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	679,109 - 698,624 (-)	NCBI	ChiLan1.0	ChiLan1.0

SEH1L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	12,948,011 - 12,987,536 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	12,947,133 - 12,987,536 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	12,948,010 - 12,987,535 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	12,937,983 - 12,977,535 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	12,938,014 - 12,977,533	NCBI
Celera	18	12,830,517 - 12,870,069 (+)	NCBI		Celera
Cytogenetic Map	18	p11.21	NCBI
HuRef	18	12,901,806 - 12,941,359 (+)	NCBI		HuRef
CHM1_1	18	12,947,369 - 12,987,144 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	13,110,691 - 13,150,271 (+)	NCBI		T2T-CHM13v2.0

Seh1l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	67,907,946 - 67,928,557 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	67,907,946 - 67,928,557 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	67,774,876 - 67,795,487 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	67,774,876 - 67,795,487 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	67,934,530 - 67,955,141 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	67,900,245 - 67,920,856 (+)	NCBI		MGSCv36	mm8
Celera	18	69,058,356 - 69,079,030 (+)	NCBI		Celera
Cytogenetic Map	18	E1	NCBI
cM Map	18	40.1	NCBI

Seh1l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	63,612,228 - 63,639,852 (+)	NCBI		GRCr8
mRatBN7.2	18	61,346,986 - 61,369,987 (+)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	18	63,417,593 - 63,440,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	64,116,344 - 64,139,264 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	61,964,195 - 61,987,162 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	63,545,150 - 63,568,101 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	18	62,724,436 - 62,747,387 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	18	59,450,531 - 59,473,483 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

SEH1L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	25,062,337 - 25,102,188 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	10,755,056 - 10,794,196 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	1,342,928 - 1,379,719 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	16,464,446 - 16,500,693 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	16,464,446 - 16,500,693 (-)	Ensembl	panpan1.1		panPan2

CEP192
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	78,352,153 - 78,383,546 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	78,351,992 - 78,541,669 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	77,753,311 - 77,784,692 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	78,413,150 - 78,444,580 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	78,413,096 - 78,605,702 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	78,127,054 - 78,158,613 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	78,158,985 - 78,190,362 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	78,443,468 - 78,474,879 (+)	NCBI		UU_Cfam_GSD_1.0

Seh1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	3,301,087 - 3,334,156 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936626	2,540,710 - 2,562,595 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936626	2,538,655 - 2,562,468 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SEH1L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	71,453,924 - 71,492,289 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	71,453,972 - 71,491,808 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	46,498,017 - 46,536,555 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Seh1l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624770	19,913,601 - 19,938,387 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013512934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01000029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01139869	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01023252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000018018 ⟹ ENSCLAP00000017841

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955402	681,436 - 698,624 (-)	Ensembl

RefSeq Acc Id:

XM_013512934 ⟹ XP_013368388

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955402	679,109 - 698,624 (-)	NCBI

Sequence:

show sequence

GGGCGAGGTACGCAGGGGCAAGGGCGGGGCCTGCGCGGCGGGCGGCTGCGGGCCTGCGGGGTCG
CGGCGTGGCGCGTCCCAGCCCGGGCCGGCTCAGAGGGTGCTGCGCAGCCATGTTCGTGGCGCGC
AGCATCGCGGCGGACCATAAGGACCTCATCCACGATGTCTCCTTCGACTTCCACGGGCGGCGCA
TGGCCACCTGCTCCAGCGACCAGAGCGTCAAGGTCTGGGATAAAAGCGAAAGTGGAGATTGGCA
TTGTACAGCCAGCTGGAAGACGCATAGTGGATCTGTGTGGCGAGTGACATGGGCCCACCCAGAA
TTCGGACAGGTTTTGGCTTCCTGTTCTTTTGACCGAACAGCTGCTGTGTGGGAAGAAATAGTTG
GAGAGTCGAATGATAAGCTGCGTGGACAGAGTCACTGGGTGAAAAGGACAACACTGGTGGATAG
CAGAACATCTGTTACTGATGTGAAATTTGCTCCCAAGCACATGGGCCTCATGTTGGCCACCTGC
TCAGCAGATGGAATAGTCAGAATCTATGAGGCCCCTGATGTCATGAATCTCAGTCAGTGGTCAC
TGCAGCATGAGATCTCTTGCAAACTAAGCTGCAGTTGCATTTCTTGGAACCCTTCAAGCTCTCG
TGCTCATGCACCCATGATTGCTGTAGGAAGTGATGATAACAGTCCAAACGCCATGGCCAAGGTC
CAGATTTTCGAATACAATGAAAACACCAGGAAGTATGCAAAAGCTGAGACTCTGCTGACTGTCA
CCGACCCAGTGCATGACATTGCCTTTGCGCCAAACTTGGGACGGTCTTTCCACACACTGGCAGT
TGCTACCAAAGATGTGAGAATTTTCACATTAAAGCCTGTGAGGAAAGAACTTACTACCTCAGGT
GGGCCAACAAAATTTGAAATCCACATCGTGGCTCAGTTTGATAACCATAACTCCCAGGTCTGGC
GAGTGAGTTGGAACATAACAGGAACAGTGCTAGCATCTTCAGGAGATGACGGCTGTGTGAGACT
GTGGAAAGCTAATTACATGGACAATTGGAAGTGCACTGGGATTCTGAAAGGTAATGGGAGCCCA
GTCAATGGGAGTTCTCAACAGGGAAACTCAAATCCTTCCCTAGGTTCAAACGTTCCCAACCTTC
AGAGCTCATTAAATGGATCTTCTGCTGGCAGGTATTTCTTTCCCCCTCTGGACTCCCCACGGGC
TGGATCGCGATGGTCCAGTTATGCCCAGCTCCTTCCTCCTCCTCCTCCTCTGCTAGAGCACTCT
TGCGATGCTGACACTGCCAGCCTCCAGTATCCTCACCCTCGCAGACGATACCTCTCTCGGCCTC
TTAATCCCTTACCTGAGAACGAAGGGGTTTAAAACACCTATCTGACACCTAAAGGCCTTATGCA
ATGCTTGTAAATGCTTCATTCCTGGCTGCTTTTTGTTCTTCTTCATTTTCTTTCAGAAGACTTT
TTATTTAGGGTCTGTCTTGCATGTATTACAAGCAGAAAGTGTTTGGATCCTAAACTTGTTTCTG
CGTCTGCATCAAAGGAACATTGGCTTCCCTGGTTGCTAACCTTTGATGAGAGGAGATGCATACA
AGGGACATTTAATGTGAAAGTTGCACAGTAGCTGACTTCAGAGTGCCTGTTGTGTAAATTTCAT
TTTGCGCTGTTACCATAGTCTTAAGTTTCTTCTGCTTCCTTACATTGGTTAATGTGAAAACATA
TCATGGAGTTCACTCTGCCTTCTAGACACAGAAGTGTTTTTACTTTTTACAGGTGATTGTTGCA
AGTGACTGGTATGTAAGATCATTCCTGTGTATAAAGCAGCAAAACATAATATGGATATTTTTGT
CTTTTTTTAATTAAAGGAAATTGCCTTTCACTACGAGGAATGACTGTTTAAAGCTTTTGTAATT
ACTGTCCAAGTAGGTTAATAATAAAATACATTTTAAAAATTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013368388	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000017841
	ENSCLAP00000017841.1

RefSeq Acc Id:

XP_013368388 ⟸ XM_013512934

- Sequence:

show sequence

MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVT
WAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGL
MLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHAPMIAVGSDDNSPN
AMAKVQIFEYNENTRKYAKAETLLTVTDPVHDIAFAPNLGRSFHTLAVATKDVRIFTLKPVRKE
LTTSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILK
GNGSPVNGSSQQGNSNPSLGSNVPNLQSSLNGSSAGRYFFPPLDSPRAGSRWSSYAQLLPPPPP
LLEHSCDADTASLQYPHPRRRYLSRPLNPLPENEGV

hide sequence

RefSeq Acc Id:

ENSCLAP00000017841 ⟸ ENSCLAT00000018018

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012236	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000018018	ENTREZGENE
	ENSCLAT00000018018.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	Sec13/Seh1_fam	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Seh1l	ENTREZGENE
PANTHER	PTHR11024	UniProtKB/TrEMBL
	PTHR11024:SF3	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A8C2VRL6_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Seh1l	SEH1 like nucleoporin		SEH1-like nucleoporin	Symbol and/or name change	5135510	APPROVED
2015-08-25	Seh1l	SEH1-like nucleoporin		SEH1-like (S. cerevisiae)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations