Dkk1 (dickkopf WNT signaling pathway inhibitor 1) - Rat Genome Database

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Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1) Chinchilla lanigera
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Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
RGD ID: 8984852
Description: ENCODES a protein that exhibits co-receptor binding (ortholog); low-density lipoprotein particle receptor binding (ortholog); receptor antagonist activity (ortholog); INVOLVED IN cell morphogenesis involved in differentiation (ortholog); embryonic limb morphogenesis (ortholog); endoderm development (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH anodontia (ortholog); Bone Fractures (ortholog); Breast Neoplasms (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dickkopf-related protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554257,353,964 - 7,357,599 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell morphogenesis involved in differentiation  (ISO)
embryonic limb morphogenesis  (ISO)
endoderm development  (ISO)
endoderm formation  (ISO)
face morphogenesis  (ISO)
forebrain development  (ISO)
hair follicle development  (ISO)
head morphogenesis  (ISO)
learning or memory  (ISO)
limb development  (ISO)
mesoderm formation  (ISO)
modulation of age-related behavioral decline  (ISO)
motor learning  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment  (ISO)
negative regulation of cardiac muscle cell differentiation  (ISO)
negative regulation of mesodermal cell fate specification  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of ossification  (ISO)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of presynapse assembly  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of midbrain dopaminergic neuron differentiation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of tau-protein kinase activity  (ISO)
regulation of endodermal cell fate specification  (ISO)
regulation of receptor internalization  (ISO)
regulation of synapse organization  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
regulation of Wnt signaling pathway  (ISO)
response to retinoic acid  (ISO)
Wnt signaling pathway involved in somitogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Dkk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554257,353,964 - 7,357,599 (+)NCBIChiLan1.0ChiLan1.0
DKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1052,314,281 - 52,318,042 (+)EnsemblGRCh38hg38GRCh38
GRCh381052,314,281 - 52,317,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371054,074,041 - 54,077,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361053,744,047 - 53,747,423 (+)NCBINCBI36hg18NCBI36
Build 341053,744,083 - 53,747,149NCBI
Celera1047,337,087 - 47,340,463 (+)NCBI
Cytogenetic Map10q21.1NCBI
HuRef1048,051,883 - 48,055,259 (+)NCBIHuRef
CHM1_11054,355,855 - 54,359,231 (+)NCBICHM1_1
Dkk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,523,276 - 30,526,896 (-)NCBIGRCm39mm39
GRCm39 Ensembl1930,523,263 - 30,527,065 (-)Ensembl
GRCm381930,545,876 - 30,549,496 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,620,366 - 30,623,986 (-)NCBIGRCm37mm9NCBIm37
MGSCv361930,611,873 - 30,615,493 (-)NCBImm8
Celera1931,330,434 - 31,334,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
Dkk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21228,381,521 - 228,385,202 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
DKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11051,084,963 - 51,088,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,084,027 - 51,089,776 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01048,950,704 - 48,953,815 (+)NCBIMhudiblu_PPA_v0panPan3
DKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12635,697,428 - 35,701,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,697,618 - 35,701,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2635,582,535 - 35,586,059 (-)NCBI
ROS_Cfam_1.02637,227,528 - 37,231,046 (-)NCBI
UMICH_Zoey_3.12635,133,162 - 35,136,678 (-)NCBI
UNSW_CanFamBas_1.02634,718,578 - 34,722,096 (-)NCBI
UU_Cfam_GSD_1.02635,960,801 - 35,964,325 (-)NCBI
Dkk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721375,285,796 - 75,288,505 (-)NCBI
SpeTri2.0NW_004936787307,290 - 309,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,487,226 - 97,490,450 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,487,854 - 97,490,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,115,155 - 106,117,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,836,803 - 78,840,158 (-)NCBI
ChlSab1.1 Ensembl978,835,162 - 78,840,146 (-)Ensembl
Vero_WHO_p1.0NW_02366604839,790,339 - 39,794,538 (-)NCBI
Dkk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479111,313,139 - 11,316,998 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013514768   ⟹   XP_013370222
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554257,353,964 - 7,357,599 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370222 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013370222   ⟸   XM_013514768
- Sequence:


Additional Information

Database Acc Id Source(s)
NCBI Gene LOC102017585 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Dkk1  dickkopf WNT signaling pathway inhibitor 1  LOC102017585  dickkopf-related protein 2-like  Symbol and/or name change 5135510 APPROVED