Mettl5 (methyltransferase 5, N6-adenosine) - Rat Genome Database

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Gene: Mettl5 (methyltransferase 5, N6-adenosine) Chinchilla lanigera
Analyze
Symbol: Mettl5
Name: methyltransferase 5, N6-adenosine (Ensembl:methyltransferase like 5)
RGD ID: 8974451
Description: ENCODES a protein that exhibits rRNA (adenine-N6-)-methyltransferase activity (ortholog); S-adenosyl-L-methionine binding (ortholog); INVOLVED IN positive regulation of translation (ortholog); rRNA methylation (ortholog); rRNA processing (ortholog); ASSOCIATED WITH autosomal recessive intellectual developmental disorder 72 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytosol (ortholog); fibrillar center (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyltransferase like 5; methyltransferase-like protein 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554494,795,925 - 4,806,847 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554494,795,925 - 4,806,757 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
fibrillar center  (ISO)
nucleolus  (ISO)
nucleus  (ISO)
postsynapse  (ISO)
presynapse  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mettl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554494,795,925 - 4,806,847 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554494,795,925 - 4,806,757 (+)NCBIChiLan1.0ChiLan1.0
METTL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382169,811,757 - 169,824,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2169,810,081 - 169,824,931 (-)EnsemblGRCh38hg38GRCh38
GRCh372170,668,267 - 170,681,415 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362170,376,513 - 170,389,599 (-)NCBINCBI36Build 36hg18NCBI36
Celera2164,284,639 - 164,297,724 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2162,556,329 - 162,569,341 (-)NCBIHuRef
CHM1_12170,674,123 - 170,687,225 (-)NCBICHM1_1
T2T-CHM13v2.02170,289,301 - 170,302,459 (-)NCBIT2T-CHM13v2.0
Mettl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,701,539 - 69,717,961 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,701,542 - 69,715,959 (-)EnsemblGRCm39 Ensembl
GRCm38269,871,195 - 69,886,634 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,871,198 - 69,885,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,709,252 - 69,723,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,672,034 - 69,686,454 (-)NCBIMGSCv36mm8
Celera271,541,239 - 71,555,439 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.95NCBI
Mettl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8375,033,605 - 75,046,359 (-)NCBIGRCr8
mRatBN7.2354,625,790 - 54,638,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,625,793 - 54,638,039 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx358,027,311 - 58,039,545 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,610,906 - 66,623,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0364,373,285 - 64,385,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0356,101,597 - 56,113,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl356,101,580 - 56,113,857 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,736,605 - 62,747,462 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4352,010,202 - 52,022,428 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera354,185,280 - 54,197,536 (-)NCBICelera
Cytogenetic Map3q21NCBI
METTL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21372,472,145 - 72,485,453 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B72,487,133 - 72,500,424 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B57,084,128 - 57,097,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B174,549,310 - 174,562,269 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B174,547,888 - 174,562,254 (-)Ensemblpanpan1.1panPan2
METTL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13614,476,493 - 14,483,553 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3614,475,186 - 14,483,502 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3614,488,088 - 14,495,268 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03614,595,355 - 14,602,541 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3614,593,956 - 14,602,515 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13614,678,173 - 14,685,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03614,670,440 - 14,677,620 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,782,152 - 14,789,334 (-)NCBIUU_Cfam_GSD_1.0
Mettl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,741,419 - 131,752,242 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936509290,675 - 306,203 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936509295,441 - 306,154 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1576,092,968 - 76,108,351 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11576,097,873 - 76,108,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21585,206,086 - 85,225,159 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METTL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11055,339,009 - 55,352,353 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1055,337,029 - 55,351,857 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,184,517 - 144,197,134 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247877,299,893 - 7,313,031 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247877,300,540 - 7,312,604 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000006311   ⟹   ENSCLAP00000006208
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554494,795,925 - 4,806,847 (+)Ensembl
RefSeq Acc Id: XM_005393246   ⟹   XP_005393303
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554494,795,925 - 4,806,757 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005393247   ⟹   XP_005393304
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554494,795,925 - 4,806,757 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005393303 (Get FASTA)   NCBI Sequence Viewer  
  XP_005393304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006208
  ENSCLAP00000006208.1
Reference Protein Sequences
RefSeq Acc Id: XP_005393303   ⟸   XM_005393246
- Peptide Label: isoform X1
- UniProtKB: A0A8C2V137 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005393304   ⟸   XM_005393247
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000006208   ⟸   ENSCLAT00000006311
Protein Domains
Methyltransferase small


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004398 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006311 ENTREZGENE
  ENSCLAT00000006311.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro DNA_methylase_N6_adenine_CS UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
  Small_mtfrase_dom UniProtKB/TrEMBL
NCBI Gene Mettl5 ENTREZGENE
PANTHER RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam MTS UniProtKB/TrEMBL
PROSITE N6_MTASE UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8C2V137 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-26 Mettl5  methyltransferase 5, N6-adenosine  Mettl5  methyltransferase like 5  Symbol and/or name change 5135510 APPROVED