Npc2 (NPC intracellular cholesterol transporter 2) - Rat Genome Database
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Gene: Npc2 (NPC intracellular cholesterol transporter 2) Chinchilla lanigera
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Symbol: Npc2
Name: NPC intracellular cholesterol transporter 2
RGD ID: 8972612
Description: ENCODES a protein that exhibits cholesterol binding (ortholog); cholesterol transfer activity (ortholog); enzyme binding (ortholog); INVOLVED IN cholesterol efflux (ortholog); cholesterol homeostasis (ortholog); cholesterol transport (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); intellectual disability (ortholog); Niemann-Pick disease (ortholog); FOUND IN extracellular space (ortholog); lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: epididymal secretory protein E1; Niemann-Pick disease, type C2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,010,976 - 1,021,144 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References


Genomics

Comparative Map Data
Npc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,010,976 - 1,021,144 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBIChiLan1.0ChiLan1.0
NPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1474,476,192 - 74,494,177 (-)EnsemblGRCh38hg38GRCh38
GRCh381474,479,935 - 74,493,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371474,946,638 - 74,960,215 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,016,396 - 74,029,837 (-)NCBINCBI36hg18NCBI36
Build 341474,016,396 - 74,029,837NCBI
Celera1454,985,030 - 54,998,469 (-)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1455,115,095 - 55,128,528 (-)NCBIHuRef
CHM1_11474,886,183 - 74,899,622 (-)NCBICHM1_1
Npc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,801,333 - 84,819,886 (-)NCBIGRCm39mm39
GRCm39 Ensembl1284,801,336 - 84,819,926 (-)Ensembl
GRCm381284,754,559 - 84,773,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,754,562 - 84,773,152 (-)EnsemblGRCm38mm10GRCm38
MGSCv371286,095,509 - 86,114,062 (-)NCBIGRCm37mm9NCBIm37
MGSCv361285,644,307 - 85,662,860 (-)NCBImm8
Celera1286,210,583 - 86,229,366 (-)NCBICelera
Cytogenetic Map12D1NCBI
Npc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26104,397,239 - 104,418,161 (-)NCBI
Rnor_6.0 Ensembl6108,467,410 - 108,488,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06108,467,410 - 108,488,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06117,060,860 - 117,081,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,793,935 - 108,814,703 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16108,797,391 - 108,818,159 (-)NCBI
Celera6102,222,115 - 102,243,035 (-)NCBICelera
Cytogenetic Map6q31NCBI
NPC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11473,875,856 - 73,894,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,875,889 - 73,894,628 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01455,033,129 - 55,046,564 (-)NCBIMhudiblu_PPA_v0panPan3
NPC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl847,628,077 - 47,650,576 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1847,641,185 - 47,650,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Npc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364883,664,171 - 3,676,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,730,514 - 97,740,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,730,532 - 97,740,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,573,100 - 103,582,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,685,699 - 51,700,557 (-)NCBI
ChlSab1.1 Ensembl2451,685,609 - 51,700,557 (-)Ensembl
Npc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473427,166,867 - 27,177,229 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009372   ⟹   ENSCLAP00000009243
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555231,010,976 - 1,021,144 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000009373   ⟹   ENSCLAP00000009244
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555231,010,976 - 1,021,144 (+)Ensembl
RefSeq Acc Id: XM_005409393   ⟹   XP_005409450
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005409394   ⟹   XP_005409451
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013507152   ⟹   XP_013362606
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555231,010,976 - 1,021,048 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005409450 (Get FASTA)   NCBI Sequence Viewer  
  XP_005409451 (Get FASTA)   NCBI Sequence Viewer  
  XP_013362606 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005409451   ⟸   XM_005409394
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005409450   ⟸   XM_005409393
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013362606   ⟸   XM_013507152
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000009243   ⟸   ENSCLAT00000009372
RefSeq Acc Id: ENSCLAP00000009244   ⟸   ENSCLAT00000009373


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006435 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000009244 ENTREZGENE
Ensembl Transcript ENSCLAT00000009373 ENTREZGENE
NCBI Gene Npc2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Npc2  NPC intracellular cholesterol transporter 2    Niemann-Pick disease, type C2  Symbol and/or name change 5135510 APPROVED