Cort (cortistatin) - Rat Genome Database

Name: Cort
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cort (cortistatin) Chinchilla lanigera

Analyze

Symbol:

Cort

Name:

cortistatin

RGD ID:

8967541

Description:

ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); neuropeptide hormone activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); neuropeptide signaling pathway (ortholog); regulation of circadian sleep/wake cycle, sleep (ortholog); ASSOCIATED WITH brain infarction (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	3,152,810 - 3,154,205 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	3,152,745 - 3,154,956 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

brain infarction (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

chromosome 1p36 deletion syndrome (ISO)

genetic disease (ISO)

immunodeficiency 14 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ISO)

neuropeptide signaling pathway (ISO)

regulation of circadian sleep/wake cycle, sleep (ISO)

Molecular Function

G protein-coupled receptor binding (ISO)

neuropeptide hormone activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cort
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	3,152,810 - 3,154,205 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	3,152,745 - 3,154,956 (-)	NCBI	ChiLan1.0	ChiLan1.0

CORT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	10,450,031 - 10,451,998 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	10,450,031 - 10,451,998 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	10,510,088 - 10,512,055 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	10,432,558 - 10,434,546 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	10,444,236 - 10,446,223	NCBI
Celera	1	9,621,375 - 9,623,363 (+)	NCBI		Celera
Cytogenetic Map	1	p36.22	ENTREZGENE
HuRef	1	9,663,393 - 9,665,676 (+)	NCBI		HuRef
CHM1_1	1	10,497,518 - 10,499,802 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	9,993,648 - 9,995,614 (+)	NCBI		T2T-CHM13v2.0

Cort
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	149,209,491 - 149,211,132 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	149,209,491 - 149,211,220 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	149,125,034 - 149,126,763 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	149,125,034 - 149,126,763 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	148,499,300 - 148,500,850 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	147,968,991 - 147,970,541 (-)	NCBI		MGSCv36	mm8
MGSCv36	4	144,510,109 - 144,511,659 (-)	NCBI		MGSCv36	mm8
Celera	4	151,391,300 - 151,392,845 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	78.89	NCBI

Cort
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	164,843,682 - 164,845,796 (-)	NCBI		GRCr8
mRatBN7.2	5	159,560,591 - 159,562,032 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	5	162,277,300 - 162,278,741 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	164,098,034 - 164,099,461 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	164,054,406 - 164,055,833 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	165,942,780 - 165,944,221 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	5	169,592,961 - 169,594,402 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	166,198,987 - 166,200,428 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	166,209,174 - 166,210,616 (-)	NCBI
Celera	5	157,831,542 - 157,832,983 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

CORT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	217,775,202 - 217,777,221 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	216,421,119 - 216,422,961 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	9,210,186 - 9,212,201 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	10,435,120 - 10,436,977 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

Cort
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	33,801,913 - 33,804,110 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936623	4,287,175 - 4,289,347 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CORT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	70,716,386 - 70,718,032 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	70,716,630 - 70,717,980 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	64,649,453 - 64,650,803 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005404018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01059018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01244129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000010956 ⟹ ENSCLAP00000010823

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955486	3,152,810 - 3,154,205 (-)	Ensembl

RefSeq Acc Id:

XM_005404018 ⟹ XP_005404075

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955486	3,152,745 - 3,154,956 (-)	NCBI

Sequence:

show sequence

CGTCACAAGTCTGAGTCCAGGCTGCACTAGGTAGTAAGACCTTATCTCAAAAAACAAAACAAAA
ACAGGTGCTGGTCTCCAGCCTGGGACTATGTGAGGGTCTGGCCGCTCCAGGTCAGCGTCCTCTG
GCTCTGATAGAGATAGTGTCTCGGCTCTCCCTACACCCGCTGTGGCGTCTGCTAGGCTGAGGGT
ACGATTGCTCGGGTGACCTTGCCCACAACCGGGCGCAGCCAGCAGCGCTGTCATTGCGCGGTCC
GGGCTCACGCTGCTCCGAGTCTCTCTGGCTTCTGGCAGATTCAGTCACTTTTTTTTTTGGTGCT
GGGGATCAAACCAGGGCCTCAGGCATGAGAAGCACGATCTCCACCCCAGCCCCGCAGTCATGTG
GGCAAAATTATACATGGGCAAAATTTCACGTCTTCAGCTCCGCCAAGGCTAATTTTATATTCTG
TTAAATCACTTGGTTTTGTTCTGATGGCTTCCTGCTTGTTGTCGGCATAATTACAAGGAAGTCG
AACTTCCTCCAAGGCAAGCGCACATGGTCCAAAATAAGAGCAGATTTGCTGTAAACGCAGGAAA
CGACCTGAGGCTTTCAATAAGGGGGCACAGTGCGGCCCCAGAATGCTTCTGTGGGCGCTCGGCG
CCTGGGCACCTGCGTCATCACTGAGGCGTGAGGAAAGGGCTCCAGGTGCTCCCCGACACGTGGA
CAACAACAGCCTGCGTCCTCCGAGCGCCAGCGCCAGGGCTGCCCAGGATGGGTGGCAGCCGAGC
CCGAGGGACGCGGGCCTGGGCCTGCAGGACCCTGCTGCTGCTGCTGCTGCTGCTGCTGCTCTGG
GGGGCCGCAGCCCCCGCCCCCGCCCTGGAAGGCGACCCCGCCAGCCTGGACAGCGTGCATGTGC
AAGAGGTGGCAGAAATAAAGAAAAACAACCTCCTGACTTTCCTTGCGAGGTGGCACGCCTGGAC
CTCCCACTCCAGCCCTGGGGACCTCGCAGGGGGCGCCGCCGGAGAGCCGGGCAAGGGGCAGGAA
GGCGCACCCCTGCAGCAGCCCCCTCGGCGAGACCAAACACGCTGCAAAAACTTCTTCTGGAAGA
CCTTCTCCTCCTGCAAATAATCTCCCCGCGATCTTGCCCAGGGAGAGCAGTGTGGACCCAATAA
AGTGAATTCAGCAGCACCGTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005404075	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000010823
	ENSCLAP00000010823.1

RefSeq Acc Id:	XP_005404075 ⟸ XM_005404018
- UniProtKB:	A0A8C2V6D0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGGSRARGTRAWACRTLLLLLLLLLLWGAAAPAPALEGDPASLDSVHVQEVAEIKKNNLLTFLA RWHAWTSHSSPGDLAGGAAGEPGKGQEGAPLQQPPRRDQTRCKNFFWKTFSSCK hide sequence

RefSeq Acc Id:

ENSCLAP00000010823 ⟸ ENSCLAT00000010956

Protein Domains

Somatostatin/Cortistatin C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007470	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000010956	ENTREZGENE
	ENSCLAT00000010956.1	UniProtKB/TrEMBL
InterPro	Somatostatin	UniProtKB/TrEMBL
	Somatostatin/Cortistatin_C	UniProtKB/TrEMBL
NCBI Gene	Cort	ENTREZGENE
PANTHER	CORTISTATIN	UniProtKB/TrEMBL
	SOMATOSTATIN	UniProtKB/TrEMBL
Pfam	Somatostatin	UniProtKB/TrEMBL
PIRSF	Somatostatin	UniProtKB/TrEMBL
UniProt	A0A8C2V6D0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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