Mxd3 (MAX dimerization protein 3)

Gene: Mxd3 (MAX dimerization protein 3) Chinchilla lanigera

Analyze

Symbol:

Mxd3

Name:

MAX dimerization protein 3

RGD ID:

8963711

Description:

ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Chromosome 5, Trisomy 5q (ortholog); Ehlers-Danlos syndrome dermatosparaxis type (ortholog); Ehlers-Danlos syndrome spondylodysplastic type 2 (ortholog); FOUND IN RNA polymerase II transcription regulator complex (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	29,555,406 - 29,559,451 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	29,555,028 - 29,560,589 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chromosome 5, Trisomy 5q (ISO)

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

genetic disease (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

Sotos syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

Cellular Component

RNA polymerase II transcription regulator complex (ISO)

Molecular Function

DNA binding (ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mxd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	29,555,406 - 29,559,451 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	29,555,028 - 29,560,589 (-)	NCBI	ChiLan1.0	ChiLan1.0

MXD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	177,305,499 - 177,312,752 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	177,301,461 - 177,312,757 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	176,732,500 - 176,739,753 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	176,666,817 - 176,671,487 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	176,666,817 - 176,671,487	NCBI
Celera	5	171,762,037 - 171,768,860 (+)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	171,653,234 - 171,660,025 (-)	NCBI		HuRef
CHM1_1	5	176,165,543 - 176,172,334 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	177,848,733 - 177,855,986 (-)	NCBI		T2T-CHM13v2.0

Mxd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	55,472,983 - 55,477,937 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	55,472,981 - 55,477,636 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	55,325,170 - 55,329,900 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	55,325,168 - 55,329,823 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	55,426,529 - 55,431,091 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	55,335,101 - 55,339,355 (-)	NCBI		MGSCv36	mm8
Celera	13	56,380,748 - 56,385,369 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	29.8	NCBI

Mxd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	9,306,552 - 9,310,278 (+)	NCBI		GRCr8
mRatBN7.2	17	9,301,430 - 9,305,156 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	9,301,399 - 9,305,157 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	9,317,852 - 9,321,578 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	10,846,971 - 10,850,712 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	9,314,244 - 9,317,970 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,830,326 - 9,834,052 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,830,332 - 9,839,452 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	11,940,006 - 11,943,732 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	15,346,165 - 15,349,891 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	15,346,164 - 15,349,891 (+)	NCBI
Celera	17	9,379,809 - 9,383,526 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

MXD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	172,391,727 - 172,402,288 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	170,531,264 - 170,541,827 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	172,609,158 - 172,615,345 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	179,673,221 - 179,679,289 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	179,673,135 - 179,677,842 (-)	Ensembl	panpan1.1		panPan2

MXD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	36,044,432 - 36,054,828 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	36,046,982 - 36,050,899 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	36,010,966 - 36,018,548 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	36,409,867 - 36,417,448 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	36,413,135 - 36,417,052 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	36,234,968 - 36,242,548 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	36,421,160 - 36,428,740 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	36,930,709 - 36,938,291 (+)	NCBI		UU_Cfam_GSD_1.0

Mxd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	122,559,791 - 122,564,441 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	1,584,783 - 1,588,931 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	1,584,047 - 1,588,930 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MXD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	80,637,323 - 80,641,950 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	80,636,778 - 80,641,346 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	82,227,494 - 82,232,062 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MXD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	79,317,049 - 79,323,811 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	79,317,436 - 79,322,431 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	10,505,494 - 10,511,490 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mxd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	12,769,245 - 12,774,778 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	12,769,031 - 12,777,613 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005376425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01008762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01183481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000022752 ⟹ ENSCLAP00000022544

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955408	29,555,406 - 29,559,451 (-)	Ensembl

RefSeq Acc Id:

XM_005376425 ⟹ XP_005376482

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955408	29,555,028 - 29,560,589 (-)	NCBI

Sequence:

show sequence

GAAAGGCTGTCTGGGAGGAAGAAGTTTGTTCCTGGTTGCACCGGTCTTAGAAGTTGCTGAAGCA
GTTGCAGAGCACTACATTGGCACTGACTCTGATCTCTCCACCACGCTGTCGCTGGGCGCCCAAG
TTACACACTGCTGAGTCAGCAATGACAAGAGAGGAGCCCCACTTGTTGACTCCATAGTTCCGAG
CTCCCAAAAAGCCAGAAGGCGTACTTCCAGGGTATGGTCTGGCTTGTTAAGCTGTTACATTACC
GAAGTCTTCGTGCTAACAATGGCTTCCTGCTGATGAACGGTGGGGCAGGGAGCGGGTAGGCAAG
CGAGGATCCTTGCTCGACACAACAGAAAGTCGAGCGTTGAGGCCCAGCCGGAGCCTGGGGTCAG
CAGATGATAGGCAGGCGTAGGGGCAGACCCTGGAGCTCAGGAGCGGGGTCCGCGCCCCCTCCGC
CGGCGCTTGCGCGTTGCGCTCCCGTTCCCCGCTCAACCCCGCCTTCAGCACCCGGGTTTTCAAA
TTTGAAACCTGCTTCTTTTCCCGCCTGAACTTGTGGACCAGCAGCGGGAGAAGGCAGGGCCTCG
AGCCAGCCAATCATGACTCAGAGGCCCTTAGTCCCCGCCCAGAAGATGACGACAGCAAGCCCCG
GGGGGCAACCCACGAATGCGCGAGCGGCGCCGGCCTGCCCCGCCCCTACGGCGTTCAAGTGCAT
GGCCAAGCCGGGAGCGCCAGGAAGCTGCTTGGGCCCTATAGCGCTGTTCTAAATATCTGGCACT
CCTCACTCGCTGGAAACTGAGGCCCAAAGACACCCAGAAACCTTTGGGGTCGCTAAGTGAAGCG
GGGAAGACACAGTAACCCCTAACTTGGGGGGACTCGCCAAGGGACCAGACCTGAACCGGCACCA
GTATCTGGTCCAAGAGAATCAGAGGCCGCTCCCGGCGGGCGGGACCCGGAGGGTGGGCTGTGGT
TCCCCGGCGCGTTCCGAAGGGGCGGGGCCAAAGGCGGGGCGCTCCCGCGAGAGGGGCTACTGGG
GGCGGGACCGGAGCCCTTATTTGTTGCTCTGTGTCAGTTACATTGTAACAAAAGTGGTACAGCC
ACTGCTCTAGCCCGCACCCTAGGCCCGCCCGCTGCCAGGTGTCGCCGAACATGGAACGCATGGC
CAGCAACATCCAGGTCCTGCTGCAAGCGGCCGAGTTCCTGGAGCGCCGCGAGAGAGAAGCGGAG
CATGGCTACGCATCGCTGTGCCCGCACCACAGTCCAGGGCCCATCCACAGGAGGAGGAAGCGAC
CCCCACAAGCTCCTGGCGCGCTGGACAGTGGGCGATCTGTGCACAATGAGCTGGAGAAGCGCAG
GAGGGCCCAGCTGAAGCGGTGCCTAGAACAGCTGAAGCAGCAGATGCCCCTGGGGGCTGACTGT
GCCCGATACACCACGCTGAGCCTGCTTCGCCGAGCAAGGACGCACATCCAGAAGTTGGAGGAGC
AGGAGCAGCGGGCCCGGTGGCTGAAAGAGAAGCTGCGCAGCAAACAACAGAGCCTGCAGCGGCA
GCTGGAGCAGCTCCAGGGGCTGCCAGGGGCAGGGGAACGTGAATGTGAGCGGGAGCGGGAGCGG
CTGCGGGCGGACAGCCTGGACTCCTCAGGGCTCTCCTCTGAGCGCTCTGACTCTGACCAAGAGG
AGCTGGAGGTAGATGTGGAGAGCCTGGTGTTCGGGGGTGAGGCACAGCTGCTGCAGAGCTTCAG
CGCAGGCCAGGAGCACAGCTACTCACACAACCCTGGCAATTGGCTATGATGCTCACTGCCCCGA
CTGCCCTCCGCTCACGCTGGGCCGATCCTGCCACGCGGGATCCTTCCCCAAGCCTCGGGGGCTG
CTCGGAACCGTTTATCTGTCAGAATGGACTGAAAGGACATGCATATGGGAACAGGTACTCCCTG
GACTTTGCTGCTGGCTACCAGGTGGCCCCTCCTGTGGGGATGGGGGAAGCACCTGGGCCACCCC
AGAGCCCCGCAGGGCAGGCAGCTTGGGCCTTCCAAGCATTAAGGTAGCACTTGCTTGCGCTGCT
CCCACAGGGGCCGGAGCTTCAGACCCTCATGTGCTCTCCCAGACAAGGCCCCTGACCTTCACCC
CACATATACTGTACAGTATTTTCATTAAAAGCCTCTTTCATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005376482	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022544
	ENSCLAP00000022544.1

RefSeq Acc Id:

XP_005376482 ⟸ XM_005376425

- UniProtKB:

A0A8C2VYJ7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERMASNIQVLLQAAEFLERREREAEHGYASLCPHHSPGPIHRRRKRPPQAPGALDSGRSVHNE
LEKRRRAQLKRCLEQLKQQMPLGADCARYTTLSLLRRARTHIQKLEEQEQRARWLKEKLRSKQQ
SLQRQLEQLQGLPGAGERECERERERLRADSLDSSGLSSERSDSDQEELEVDVESLVFGGEAQL
LQSFSAGQEHSYSHNPGNWL

hide sequence

RefSeq Acc Id:

ENSCLAP00000022544 ⟸ ENSCLAT00000022752

Protein Domains

bHLH

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015467	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022752	ENTREZGENE
	ENSCLAT00000022752.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Mxd3	ENTREZGENE
PANTHER	MAX DIMERIZATION PROTEIN 3	UniProtKB/TrEMBL
	MAX DIMERIZATION, MAD	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	A0A8C2VYJ7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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