Etfa (electron transfer flavoprotein subunit alpha)

Gene: Etfa (electron transfer flavoprotein subunit alpha) Chinchilla lanigera

Analyze

Symbol:

Etfa

Name:

electron transfer flavoprotein subunit alpha

RGD ID:

8961424

Description:

ENCODES a protein that exhibits electron transfer activity (ortholog); flavin adenine dinucleotide binding (ortholog); oxidoreductase activity (ortholog); INVOLVED IN amino acid catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); respiratory electron transport chain (ortholog); PARTICIPATES IN fatty acid beta degradation pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog); FOUND IN electron transfer flavoprotein complex (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

electron transfer flavoprotein alpha subunit; electron transfer flavoprotein subunit alpha, mitochondrial; electron-transfer-flavoprotein, alpha polypeptide

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	1,392,479 - 1,451,591 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	1,392,526 - 1,451,591 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

Glutaric Aciduria 2 (ISO)

hepatocellular carcinoma (ISO)

multiple acyl-CoA dehydrogenase deficiency (ISO)

osteoarthritis (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid catabolic process (ISO)

fatty acid beta-oxidation using acyl-CoA dehydrogenase (ISO)

respiratory electron transport chain (ISO)

Cellular Component

electron transfer flavoprotein complex (ISO)

mitochondrion (ISO)

Molecular Function

electron transfer activity (ISO)

flavin adenine dinucleotide binding (ISO)

oxidoreductase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

fatty acid beta degradation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Etfa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	1,392,479 - 1,451,591 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	1,392,526 - 1,451,591 (-)	NCBI	ChiLan1.0	ChiLan1.0

ETFA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	76,215,353 - 76,311,469 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	76,188,555 - 76,311,730 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	76,507,694 - 76,603,810 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	74,295,636 - 74,390,865 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	74,295,690 - 74,390,784	NCBI
Celera	15	53,434,725 - 53,530,031 (-)	NCBI		Celera
Cytogenetic Map	15	q24.2-q24.3	NCBI
HuRef	15	53,265,219 - 53,360,736 (-)	NCBI		HuRef
CHM1_1	15	76,628,067 - 76,723,216 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	74,086,268 - 74,182,563 (-)	NCBI		T2T-CHM13v2.0

Etfa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	55,361,720 - 55,419,528 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	55,361,792 - 55,419,527 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	55,454,436 - 55,512,243 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	55,454,508 - 55,512,243 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	55,302,243 - 55,360,050 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	55,252,660 - 55,310,380 (-)	NCBI		MGSCv36	mm8
Celera	9	52,696,302 - 52,754,125 (-)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	30.13	NCBI

Etfa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	64,731,192 - 64,787,965 (-)	NCBI		GRCr8
mRatBN7.2	8	55,835,115 - 55,891,890 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	55,835,134 - 55,891,969 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	61,377,604 - 61,434,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	59,656,602 - 59,713,381 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	57,520,835 - 57,577,614 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	60,028,786 - 60,086,352 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	60,028,789 - 60,086,403 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	58,608,416 - 58,665,383 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	59,013,798 - 59,072,013 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	59,032,895 - 59,091,022 (-)	NCBI
Celera	8	55,318,874 - 55,375,436 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

ETFA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	65,413,801 - 65,512,497 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	69,578,211 - 69,676,833 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	55,128,686 - 55,227,369 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	74,720,198 - 74,818,494 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	74,720,198 - 74,818,494 (-)	Ensembl	panpan1.1		panPan2

ETFA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	39,848,241 - 39,925,809 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	39,848,270 - 39,964,823 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	39,707,332 - 39,784,202 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	40,052,278 - 40,129,606 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	40,052,340 - 40,129,601 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	40,001,191 - 40,078,170 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	40,047,242 - 40,124,599 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	40,285,034 - 40,362,157 (+)	NCBI		UU_Cfam_GSD_1.0

Etfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	118,020,782 - 118,094,606 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	35,868,757 - 35,943,139 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	35,868,851 - 35,942,662 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ETFA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	56,450,520 - 56,540,253 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	56,450,508 - 56,540,275 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	60,946,251 - 61,036,017 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ETFA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	6,970,593 - 7,075,077 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	6,970,584 - 7,076,049 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	134,642,527 - 134,750,547 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Etfa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624894	1,874,695 - 1,936,120 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624894	1,874,859 - 1,935,587 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005393471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01042364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01121130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000013041 ⟹ ENSCLAP00000012892

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955450	1,392,479 - 1,451,591 (-)	Ensembl

RefSeq Acc Id:

XM_005393471 ⟹ XP_005393528

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955450	1,392,526 - 1,451,591 (-)	NCBI

Sequence:

show sequence

GTTCGCGCGTCTCGCGAGAGCCGACTACCCGTGTGGCAGCGCCGCCGAGGTCGGAAGGTTGAGG
TGGAGGGACCACTGTTCTGGTGGCAGCAGAGACCATGTTCCGGGCAGCAGTTCCGGGGCGGCTC
CGGCGAGCGGCCTCATTGCTCCGATTTCAGAGTACCCTTGTAATAGCTGAGCATGCTAATGACT
CCCTGGCACCCATTACTTTGAACACTATCACTGCAGCCAGACGCCTTGGAGGTGAGGTGTCCTG
TTTAGTAGCTGGAACCAAATGTGACAAGGTGGTACAAGATCTCTGTAAAGTAGCAGGGGTAGCG
AAAGTTCTGGTGGCTCAGCATGATGCCTACCAAGGCCTGCTTCCAGAGGAGCTGACGCCATTGG
TTCTGGCCACACAGAAGCAGTTCAATTACACACACATCTGTGCTGGCGCCTCTGCCTTCGGAAA
GAACCTTATGCCCAGAGTAGCAGCCAAACTTGATGTTGCCCCGATTTCTGACATCATTGAGATC
AAGTCACCTGACACATTTGTGAGAACTATTTATGCAGGAAATGCTTTATGTACAGTGAAGTGTG
ATGAGAAGGTGAAGGTGTTTTCTGTCCGAGGAACATCTTTTGAAGCTGCAGCAACAAGTGGAGG
TAGTGCCAGTTCAGAAAATGCACCAAGTTCTTCCCCAGTGGGAATATCAGAGTGGCTTGACCAG
AAGCTAACGAAAAGTGATCGGCCAGAGCTGACTGGTGCCAAAGTGGTCGTATCTGGCGGTCGTG
GTTTGAAGAGTGGAGAGAATTTTAAATTGTTGTATGACTTGGCAGATCAACTACATGCTGCAGT
TGGGGCTTCCCGAGCGGCTGTTGATGCTGGCTTCGTTCCCAATGATATGCAGGTTGGTCAGACA
GGAAAAATCGTAGCACCAGAACTTTATATTGCTGTTGGGATCTCTGGAGCCATCCAGCATTTAG
CTGGGATGAAGGATAGCAAGACGATTGTGGCTATTAACAAAGACCCAGAAGCCCCAATTTTCCA
GGTGGCAGATTATGGAATAGTTGCAGATTTATTTAAGGTAGTTCCTGAAATGACCGAGCTGTTG
AAGAAGAAGTGAATCGTGATTGTGCCGTAAGAAGAAAATCTGTGTGAAAGTATTCAGTTGAAAT
CAGAAATTTACAATTTGAGGAAAAAAACCTAACAGCAGCCAGAATACTTTGCAATGGGACTATG
ACTATGTTTCTTTTTAATTATTTGTGGTCACAAACAGTTTTTTGGAGATTTTCTAATTCTGTAA
TAAGATCTCTAATAAAGCCTTGCCACAACTTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005393528	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012892
	ENSCLAP00000012892.1

RefSeq Acc Id:

XP_005393528 ⟸ XM_005393471

- UniProtKB:

A0A8C2VHS9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFRAAVPGRLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAARRLGGEVSCLVAGTKCDKVV
QDLCKVAGVAKVLVAQHDAYQGLLPEELTPLVLATQKQFNYTHICAGASAFGKNLMPRVAAKLD
VAPISDIIEIKSPDTFVRTIYAGNALCTVKCDEKVKVFSVRGTSFEAAATSGGSASSENAPSSS
PVGISEWLDQKLTKSDRPELTGAKVVVSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGF
VPNDMQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLF
KVVPEMTELLKKK

hide sequence

RefSeq Acc Id:

ENSCLAP00000012892 ⟸ ENSCLAT00000013041

Protein Domains

Electron transfer flavoprotein alpha/beta-subunit N-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008902	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000013041	ENTREZGENE
	ENSCLAT00000013041.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.620	UniProtKB/TrEMBL
	TPP-binding domain	UniProtKB/TrEMBL
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/TrEMBL
	ETF_a/b_N	UniProtKB/TrEMBL
	ETF_a/FixB	UniProtKB/TrEMBL
	ETF_alpha_N	UniProtKB/TrEMBL
	ETF_asu_C	UniProtKB/TrEMBL
	ETF_asu_C_CS	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
NCBI Gene	Etfa	ENTREZGENE
PANTHER	ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR43153	UniProtKB/TrEMBL
Pfam	ETF	UniProtKB/TrEMBL
	ETF_alpha	UniProtKB/TrEMBL
PIRSF	Electra_flavoP_a	UniProtKB/TrEMBL
PROSITE	ETF_ALPHA	UniProtKB/TrEMBL
SMART	ETF	UniProtKB/TrEMBL
Superfamily-SCOP	Adenine nucleotide alpha hydrolases-like	UniProtKB/TrEMBL
	SSF52467	UniProtKB/TrEMBL
UniProt	A0A8C2VHS9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	Etfa	electron transfer flavoprotein subunit alpha		electron transfer flavoprotein alpha subunit	Symbol and/or name change	5135510	APPROVED
2016-08-03	Etfa	electron transfer flavoprotein alpha subunit		electron-transfer-flavoprotein, alpha polypeptide	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations