Trpv4 (transient receptor potential cation channel subfamily V member 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Trpv4 (transient receptor potential cation channel subfamily V member 4) Chinchilla lanigera
Analyze
Symbol: Trpv4
Name: transient receptor potential cation channel subfamily V member 4
RGD ID: 8959460
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); alpha-tubulin binding (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); actin filament organization (ortholog); ATP export (ortholog); ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy (ortholog); autosomal recessive progressive external ophthalmoplegia 1 (ortholog); bone development disease (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: transient receptor potential cation channel, subfamily V, member 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,744,176 - 8,783,741 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,744,865 - 8,781,644 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
actin filament organization  (ISO)
ATP export  (ISO)
ATP transport  (ISO)
blood vessel endothelial cell delamination  (ISO)
calcium ion import  (ISO)
calcium ion import across plasma membrane  (ISO)
calcium ion import into cytosol  (ISO)
calcium ion transmembrane transport  (ISO)
calcium ion transport  (ISO)
cartilage development involved in endochondral bone morphogenesis  (ISO)
cartilage homeostasis  (ISO)
cell-cell junction assembly  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular hypotonic response  (ISO)
cellular hypotonic salinity response  (ISO)
cellular response to heat  (ISO)
cellular response to osmotic stress  (ISO)
cortical microtubule organization  (ISO)
diet induced thermogenesis  (ISO)
energy homeostasis  (ISO)
glucose homeostasis  (ISO)
hyperosmotic salinity response  (ISO)
hypotonic response  (ISO)
microtubule polymerization  (ISO)
multicellular organismal water homeostasis  (ISO)
negative regulation of brown fat cell differentiation  (ISO)
negative regulation of cell volume  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
osmosensory signaling pathway  (ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage inflammatory protein 1 alpha production  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of microtubule depolymerization  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of P-type sodium:potassium-exchanging transporter activity  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of striated muscle contraction  (ISO)
positive regulation of vascular permeability  (ISO)
regulation of aerobic respiration  (ISO)
regulation of blood pressure  (ISO)
regulation of heart rate  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of response to osmotic stress  (ISO)
relaxation of vascular associated smooth muscle  (ISO)
response to fatty acid  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to osmotic stress  (ISO)
vasopressin secretion  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Trpv4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,744,176 - 8,783,741 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,744,865 - 8,781,644 (+)NCBIChiLan1.0ChiLan1.0
TRPV4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12109,783,087 - 109,833,406 (-)EnsemblGRCh38hg38GRCh38
GRCh3812109,783,087 - 109,833,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712110,220,892 - 110,271,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,705,277 - 108,755,595 (-)NCBINCBI36hg18NCBI36
Celera12109,845,179 - 109,895,568 (-)NCBI
Cytogenetic Map12q24.11NCBI
HuRef12107,237,035 - 107,287,147 (-)NCBIHuRef
CHM1_112110,188,702 - 110,239,020 (-)NCBICHM1_1
Trpv4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,760,213 - 114,796,497 (-)NCBIGRCm39mm39
GRCm39 Ensembl5114,760,213 - 114,796,482 (-)Ensembl
GRCm385114,622,152 - 114,658,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,622,152 - 114,658,421 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,072,163 - 115,108,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv365114,883,153 - 114,919,388 (-)NCBImm8
Celera5111,719,696 - 111,755,858 (-)NCBICelera
Cytogenetic Map5FNCBI
Trpv4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21241,938,533 - 41,977,517 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1241,938,560 - 41,977,517 (+)Ensembl
Rnor_6.01247,698,915 - 47,737,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,698,947 - 47,737,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,492,064 - 49,529,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,226,933 - 43,265,889 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11243,090,320 - 43,129,277 (+)NCBI
Celera1243,552,408 - 43,590,250 (+)NCBICelera
Cytogenetic Map12q16NCBI
TRPV4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112110,754,238 - 110,786,182 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,754,238 - 110,786,182 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012107,359,005 - 107,409,359 (-)NCBIMhudiblu_PPA_v0panPan3
TRPV4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,293,334 - 17,330,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2617,262,100 - 17,330,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,472,505 - 18,493,002 (-)NCBI
ROS_Cfam_1.02617,652,672 - 17,673,399 (+)NCBI
UMICH_Zoey_3.12618,683,516 - 18,704,163 (-)NCBI
UNSW_CanFamBas_1.02617,643,537 - 17,664,298 (+)NCBI
UU_Cfam_GSD_1.02617,660,529 - 17,681,097 (+)NCBI
Trpv4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,028,138 - 144,051,340 (+)NCBI
SpeTri2.0NW_0049367691,424,526 - 1,447,547 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPV4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,125,869 - 41,169,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,125,819 - 41,169,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,641,455 - 43,683,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPV4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,020,972 - 105,072,660 (-)NCBI
Vero_WHO_p1.0NW_023666037140,046,822 - 140,098,634 (+)NCBI
Trpv4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,675,625 - 10,685,351 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000015785   ⟹   ENSCLAP00000015623
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554558,744,176 - 8,783,741 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000015786   ⟹   ENSCLAP00000015624
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554558,759,278 - 8,781,184 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000015787   ⟹   ENSCLAP00000015625
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554558,759,278 - 8,781,184 (+)Ensembl
RefSeq Acc Id: XM_005396446   ⟹   XP_005396503
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554558,744,877 - 8,781,644 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396447   ⟹   XP_005396504
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554558,745,062 - 8,781,644 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520488   ⟹   XP_013375942
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554558,744,865 - 8,780,478 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005396503 (Get FASTA)   NCBI Sequence Viewer  
  XP_005396504 (Get FASTA)   NCBI Sequence Viewer  
  XP_013375942 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005396503   ⟸   XM_005396446
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005396504   ⟸   XM_005396447
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013375942   ⟸   XM_013520488
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000015625   ⟸   ENSCLAT00000015787
RefSeq Acc Id: ENSCLAP00000015624   ⟸   ENSCLAT00000015786
RefSeq Acc Id: ENSCLAP00000015623   ⟸   ENSCLAT00000015785


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010741 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000015623 ENTREZGENE
  ENSCLAP00000015624 ENTREZGENE
Ensembl Transcript ENSCLAT00000015785 ENTREZGENE
  ENSCLAT00000015786 ENTREZGENE
NCBI Gene Trpv4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Trpv4  transient receptor potential cation channel subfamily V member 4    transient receptor potential cation channel, subfamily V, member 4  Symbol and/or name change 5135510 APPROVED