Sla2 (Src like adaptor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Sla2 (Src like adaptor 2) Chinchilla lanigera
Analyze
Symbol: Sla2
Name: Src like adaptor 2
RGD ID: 8951047
Description: ENCODES a protein that exhibits signaling adaptor activity (ortholog); INVOLVED IN negative regulation of calcium-mediated signaling (ortholog); negative regulation of T cell receptor signaling pathway (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH focal epilepsy (ortholog); genetic disease (ortholog); FOUND IN cytoplasmic vesicle (ortholog); Golgi apparatus (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: src-like-adapter 2; Src-like-adaptor 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,986,028 - 25,003,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,978,447 - 25,003,732 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Sla2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,986,028 - 25,003,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,978,447 - 25,003,732 (+)NCBIChiLan1.0ChiLan1.0
SLA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,612,318 - 36,646,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,612,318 - 36,646,196 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,240,721 - 35,274,599 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362034,674,336 - 34,707,972 (-)NCBINCBI36Build 36hg18NCBI36
Build 342034,674,339 - 34,707,972NCBI
Celera2031,947,996 - 31,982,111 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2031,976,969 - 32,010,653 (-)NCBIHuRef
CHM1_12035,142,627 - 35,176,530 (-)NCBICHM1_1
T2T-CHM13v2.02038,336,183 - 38,370,537 (-)NCBIT2T-CHM13v2.0
Sla2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,716,071 - 156,729,161 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,714,377 - 156,729,112 (-)EnsemblGRCm39 Ensembl
GRCm382156,874,151 - 156,887,250 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2156,872,457 - 156,887,192 (-)EnsemblGRCm38mm10GRCm38
MGSCv372156,698,658 - 156,712,814 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362156,698,658 - 156,712,928 (-)NCBIMGSCv36mm8
Celera2162,808,644 - 162,822,518 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.89NCBI
Sla2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83165,821,164 - 165,848,087 (-)NCBIGRCr8
mRatBN7.23145,367,070 - 145,383,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,368,598 - 145,382,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,234,054 - 149,247,445 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03157,850,772 - 157,864,130 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,589,831 - 155,603,360 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03152,942,838 - 153,004,047 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3152,944,452 - 153,001,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,742,486 - 158,752,778 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43147,277,668 - 147,290,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3144,085,665 - 144,098,964 (-)NCBICelera
Cytogenetic Map3q42NCBI
SLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,350,879 - 42,387,763 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,343,837 - 42,381,788 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02032,945,409 - 32,978,966 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,065,385 - 34,098,581 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,065,385 - 34,098,581 (-)Ensemblpanpan1.1panPan2
SLA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,396,187 - 25,426,789 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,396,900 - 25,422,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,039,425 - 25,072,052 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,091,095 - 26,123,942 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,094,518 - 26,120,342 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,369,896 - 25,402,347 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,468,792 - 25,501,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02425,959,331 - 25,992,034 (-)NCBIUU_Cfam_GSD_1.0
Sla2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,320,591 - 174,344,978 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,413,108 - 4,428,110 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,408,531 - 4,427,476 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1739,875,628 - 39,902,940 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11739,875,625 - 39,904,838 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666054655,122 - 689,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sla2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,853,144 - 2,881,116 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,853,183 - 2,882,269 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000024697   ⟹   ENSCLAP00000024462
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542224,986,028 - 25,003,732 (+)Ensembl
RefSeq Acc Id: XM_005384738   ⟹   XP_005384795
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542224,978,447 - 25,003,732 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005384739   ⟹   XP_005384796
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542224,978,447 - 25,003,732 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005384795 (Get FASTA)   NCBI Sequence Viewer  
  XP_005384796 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024462
  ENSCLAP00000024462.1
Reference Protein Sequences
RefSeq Acc Id: XP_005384795   ⟸   XM_005384738
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W3S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005384796   ⟸   XM_005384739
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W3S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000024462   ⟸   ENSCLAT00000024697
Protein Domains
SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024697 ENTREZGENE
  ENSCLAT00000024697.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Grb2-like UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene Sla2 ENTREZGENE
PANTHER PROTEIN ENHANCER OF SEVENLESS 2B UniProtKB/TrEMBL
  SRC-LIKE-ADAPTOR 2 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8C2W3S1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Sla2  Src like adaptor 2    Src-like-adaptor 2  Symbol and/or name change 5135510 APPROVED